An ignored risk factor in toxicology: The total imprecision of exposure assessment
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were...
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2010
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Online Access: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:26863667 https://doi.org/10.1351/PAC-CON-09-05-04 |
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ftharvardudash:oai:dash.harvard.edu:1/26863667 2023-05-15T16:10:51+02:00 An ignored risk factor in toxicology: The total imprecision of exposure assessment Grandjean, Philippe Budtz-Jørgensen, Esben 2010 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:26863667 https://doi.org/10.1351/PAC-CON-09-05-04 en_US eng Walter de Gruyter GmbH doi:10.1351/PAC-CON-09-05-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856963/ Pure and Applied Chemistry Grandjean, Philippe, and Esben Budtz-Jørgensen. 2010. “An Ignored Risk Factor in Toxicology: The Total Imprecision of Exposure Assessment.” Pure and Applied Chemistry 82 (2) (January 25). doi:10.1351/pac-con-09-05-04. 1365-3075 http://nrs.harvard.edu/urn-3:HUL.InstRepos:26863667 environmental exposure imprecision quality assurance risk assessment uncertainty Journal Article 2010 ftharvardudash https://doi.org/10.1351/PAC-CON-09-05-04 https://doi.org/10.1351/pac-con-09-05-04 2022-04-05T18:07:12Z Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were determined in cord blood, cord tissue, and maternal hair. We determined their mutual correlations and their associations with the child's neurobehavioral effect variables at age 7 years. The exposure biomarkers correlated well with one another, but the cord blood mercury concentration showed the best associations with neurobehavioral deficits. Because at least three exposure parameters were available, factor analysis and structural equation modeling could be applied to determine the total imprecision of each biomarker. For the cord-blood parameter, the total imprecision was 25-30%, and almost twice as much for maternal hair. The total imprecision of these biomarkers much exceeded the normal laboratory variability of less than 5%. Such imprecision can cause underestimation of dose-related toxicity, and data analysis should therefore include sensitivity analyses that take this factor into account. Ignoring preanalytical imprecision may cause serious bias. Accepted Manuscript Article in Journal/Newspaper Faroe Islands Harvard University: DASH - Digital Access to Scholarship at Harvard Faroe Islands Pure and Applied Chemistry 82 2 383 391 |
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Harvard University: DASH - Digital Access to Scholarship at Harvard |
op_collection_id |
ftharvardudash |
language |
English |
topic |
environmental exposure imprecision quality assurance risk assessment uncertainty |
spellingShingle |
environmental exposure imprecision quality assurance risk assessment uncertainty Grandjean, Philippe Budtz-Jørgensen, Esben An ignored risk factor in toxicology: The total imprecision of exposure assessment |
topic_facet |
environmental exposure imprecision quality assurance risk assessment uncertainty |
description |
Quality assurance of exposure biomarkers usually focuses on laboratory performance only. Using data from a prospective birth cohort study in the Faroe Islands, we have assessed the total imprecision of exposure biomarkers. As biomarkers of prenatal methylmercury exposure, mercury concentrations were determined in cord blood, cord tissue, and maternal hair. We determined their mutual correlations and their associations with the child's neurobehavioral effect variables at age 7 years. The exposure biomarkers correlated well with one another, but the cord blood mercury concentration showed the best associations with neurobehavioral deficits. Because at least three exposure parameters were available, factor analysis and structural equation modeling could be applied to determine the total imprecision of each biomarker. For the cord-blood parameter, the total imprecision was 25-30%, and almost twice as much for maternal hair. The total imprecision of these biomarkers much exceeded the normal laboratory variability of less than 5%. Such imprecision can cause underestimation of dose-related toxicity, and data analysis should therefore include sensitivity analyses that take this factor into account. Ignoring preanalytical imprecision may cause serious bias. Accepted Manuscript |
format |
Article in Journal/Newspaper |
author |
Grandjean, Philippe Budtz-Jørgensen, Esben |
author_facet |
Grandjean, Philippe Budtz-Jørgensen, Esben |
author_sort |
Grandjean, Philippe |
title |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_short |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_full |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_fullStr |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_full_unstemmed |
An ignored risk factor in toxicology: The total imprecision of exposure assessment |
title_sort |
ignored risk factor in toxicology: the total imprecision of exposure assessment |
publisher |
Walter de Gruyter GmbH |
publishDate |
2010 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:26863667 https://doi.org/10.1351/PAC-CON-09-05-04 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_relation |
doi:10.1351/PAC-CON-09-05-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856963/ Pure and Applied Chemistry Grandjean, Philippe, and Esben Budtz-Jørgensen. 2010. “An Ignored Risk Factor in Toxicology: The Total Imprecision of Exposure Assessment.” Pure and Applied Chemistry 82 (2) (January 25). doi:10.1351/pac-con-09-05-04. 1365-3075 http://nrs.harvard.edu/urn-3:HUL.InstRepos:26863667 |
op_doi |
https://doi.org/10.1351/PAC-CON-09-05-04 https://doi.org/10.1351/pac-con-09-05-04 |
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Pure and Applied Chemistry |
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82 |
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2 |
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383 |
op_container_end_page |
391 |
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1765995989259255808 |