Insights into the Evolution of Longevity from the Bowhead Whale Genome
Summary The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis o...
Published in: | Cell Reports |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Cell Press
2015
|
Subjects: | |
Online Access: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:21462496 https://doi.org/10.1016/j.celrep.2014.12.008 |
id |
ftharvardudash:oai:dash.harvard.edu:1/21462496 |
---|---|
record_format |
openpolar |
spelling |
ftharvardudash:oai:dash.harvard.edu:1/21462496 2023-05-15T15:35:58+02:00 Insights into the Evolution of Longevity from the Bowhead Whale Genome Keane, Michael Semeiks, Jeremy Webb, Andrew E. Li, Yang I. Quesada, Víctor Craig, Thomas Madsen, Lone Bruhn van Dam, Sipko Brawand, David Marques, Patrícia I. Michalak, Pawel Kang, Lin Bhak, Jong Yim, Hyung-Soon Grishin, Nick V. Nielsen, Nynne Hjort Heide-Jørgensen, Mads Peter Oziolor, Elias M. Matson, Cole W. Church, George M. Stuart, Gary W. Patton, John C. George, J. Craig Suydam, Robert Larsen, Knud López-Otín, Carlos O’Connell, Mary J. Bickham, John W. Thomsen, Bo de Magalhães, João Pedro 2015 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:21462496 https://doi.org/10.1016/j.celrep.2014.12.008 en_US eng Cell Press doi:10.1016/j.celrep.2014.12.008 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536333/pdf/ Cell Reports Keane, M., J. Semeiks, A. Webb, Y. Li, V. Quesada, T. Craig, L. Madsen, et al. 2015. “Insights into the Evolution of Longevity from the Bowhead Whale Genome.” Cell Reports 10 (1): 112-122. doi:10.1016/j.celrep.2014.12.008. http://dx.doi.org/10.1016/j.celrep.2014.12.008. 2211-1247 http://nrs.harvard.edu/urn-3:HUL.InstRepos:21462496 Journal Article 2015 ftharvardudash https://doi.org/10.1016/j.celrep.2014.12.008 2022-04-05T06:47:18Z Summary The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species. Version of Record Article in Journal/Newspaper Balaena mysticetus bowhead whale Harvard University: DASH - Digital Access to Scholarship at Harvard Cell Reports 10 1 112 122 |
institution |
Open Polar |
collection |
Harvard University: DASH - Digital Access to Scholarship at Harvard |
op_collection_id |
ftharvardudash |
language |
English |
description |
Summary The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species. Version of Record |
format |
Article in Journal/Newspaper |
author |
Keane, Michael Semeiks, Jeremy Webb, Andrew E. Li, Yang I. Quesada, Víctor Craig, Thomas Madsen, Lone Bruhn van Dam, Sipko Brawand, David Marques, Patrícia I. Michalak, Pawel Kang, Lin Bhak, Jong Yim, Hyung-Soon Grishin, Nick V. Nielsen, Nynne Hjort Heide-Jørgensen, Mads Peter Oziolor, Elias M. Matson, Cole W. Church, George M. Stuart, Gary W. Patton, John C. George, J. Craig Suydam, Robert Larsen, Knud López-Otín, Carlos O’Connell, Mary J. Bickham, John W. Thomsen, Bo de Magalhães, João Pedro |
spellingShingle |
Keane, Michael Semeiks, Jeremy Webb, Andrew E. Li, Yang I. Quesada, Víctor Craig, Thomas Madsen, Lone Bruhn van Dam, Sipko Brawand, David Marques, Patrícia I. Michalak, Pawel Kang, Lin Bhak, Jong Yim, Hyung-Soon Grishin, Nick V. Nielsen, Nynne Hjort Heide-Jørgensen, Mads Peter Oziolor, Elias M. Matson, Cole W. Church, George M. Stuart, Gary W. Patton, John C. George, J. Craig Suydam, Robert Larsen, Knud López-Otín, Carlos O’Connell, Mary J. Bickham, John W. Thomsen, Bo de Magalhães, João Pedro Insights into the Evolution of Longevity from the Bowhead Whale Genome |
author_facet |
Keane, Michael Semeiks, Jeremy Webb, Andrew E. Li, Yang I. Quesada, Víctor Craig, Thomas Madsen, Lone Bruhn van Dam, Sipko Brawand, David Marques, Patrícia I. Michalak, Pawel Kang, Lin Bhak, Jong Yim, Hyung-Soon Grishin, Nick V. Nielsen, Nynne Hjort Heide-Jørgensen, Mads Peter Oziolor, Elias M. Matson, Cole W. Church, George M. Stuart, Gary W. Patton, John C. George, J. Craig Suydam, Robert Larsen, Knud López-Otín, Carlos O’Connell, Mary J. Bickham, John W. Thomsen, Bo de Magalhães, João Pedro |
author_sort |
Keane, Michael |
title |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_short |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_full |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_fullStr |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_full_unstemmed |
Insights into the Evolution of Longevity from the Bowhead Whale Genome |
title_sort |
insights into the evolution of longevity from the bowhead whale genome |
publisher |
Cell Press |
publishDate |
2015 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:21462496 https://doi.org/10.1016/j.celrep.2014.12.008 |
genre |
Balaena mysticetus bowhead whale |
genre_facet |
Balaena mysticetus bowhead whale |
op_relation |
doi:10.1016/j.celrep.2014.12.008 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536333/pdf/ Cell Reports Keane, M., J. Semeiks, A. Webb, Y. Li, V. Quesada, T. Craig, L. Madsen, et al. 2015. “Insights into the Evolution of Longevity from the Bowhead Whale Genome.” Cell Reports 10 (1): 112-122. doi:10.1016/j.celrep.2014.12.008. http://dx.doi.org/10.1016/j.celrep.2014.12.008. 2211-1247 http://nrs.harvard.edu/urn-3:HUL.InstRepos:21462496 |
op_doi |
https://doi.org/10.1016/j.celrep.2014.12.008 |
container_title |
Cell Reports |
container_volume |
10 |
container_issue |
1 |
container_start_page |
112 |
op_container_end_page |
122 |
_version_ |
1766366313390800896 |