Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping
Background: To evaluate and quantify the impact of a novel image-based motion correction technique in myocardial T2 mapping in terms of measurement reproducibility and spatial variability. Methods: Twelve healthy adult subjects were imaged using breath-hold (BH), free breathing (FB), and free breath...
Published in: | Journal of Cardiovascular Magnetic Resonance |
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ftharvardudash:oai:dash.harvard.edu:1/17295773 2023-05-15T14:54:27+02:00 Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping Roujol, Sébastien Basha, Tamer A. Weingärtner, Sebastian Akçakaya, Mehmet Berg, Sophie Manning, Warren J. Nezafat, Reza 2015 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295773 https://doi.org/10.1186/s12968-015-0141-1 en_US eng BioMed Central doi:10.1186/s12968-015-0141-1 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465156/pdf/ Journal of Cardiovascular Magnetic Resonance Roujol, Sébastien, Tamer A. Basha, Sebastian Weingärtner, Mehmet Akçakaya, Sophie Berg, Warren J. Manning, and Reza Nezafat. 2015. “Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping.” Journal of Cardiovascular Magnetic Resonance 17 (1): 46. doi:10.1186/s12968-015-0141-1. http://dx.doi.org/10.1186/s12968-015-0141-1. 1097-6647 http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295773 Motion correction Image registration Quantitative myocardial tissue characterization Myocardial T Journal Article 2015 ftharvardudash https://doi.org/10.1186/s12968-015-0141-1 2022-04-05T09:36:25Z Background: To evaluate and quantify the impact of a novel image-based motion correction technique in myocardial T2 mapping in terms of measurement reproducibility and spatial variability. Methods: Twelve healthy adult subjects were imaged using breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV) myocardial T2 mapping sequences. Fifty patients referred for clinical CMR were imaged using the FB + NAV sequence. All sequences used a T2 prepared (T2prep) steady-state free precession acquisition. In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC). DICE similarity coefficient (DSC) and myocardial boundary errors (MBE) were measured to quantify the motion estimation accuracy in healthy subjects. T2 mapping reproducibility and spatial variability were evaluated in healthy subjects using 5 repetitions of the FB + NAV sequence with either 4 or 20 T2prep echo times (TE). Subjective T2 map quality was assessed in patients by an experienced reader using a 4-point scale (1-non diagnostic, 4-excellent). Results: ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001). Improved reproducibility (4TE: 5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016; 20TE: 3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002), reduced spatial variability (4TE: 12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001; 20TE: 9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms) and improved subjective score of T2 map quality (3.43 ± 0.79 vs. 3.69 ± 0.55, p < 0.001) were obtained using ARCTIC. Conclusions: The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping. Version of Record Article in Journal/Newspaper Arctic Harvard University: DASH - Digital Access to Scholarship at Harvard Arctic Journal of Cardiovascular Magnetic Resonance 17 1 |
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Open Polar |
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Harvard University: DASH - Digital Access to Scholarship at Harvard |
op_collection_id |
ftharvardudash |
language |
English |
topic |
Motion correction Image registration Quantitative myocardial tissue characterization Myocardial T |
spellingShingle |
Motion correction Image registration Quantitative myocardial tissue characterization Myocardial T Roujol, Sébastien Basha, Tamer A. Weingärtner, Sebastian Akçakaya, Mehmet Berg, Sophie Manning, Warren J. Nezafat, Reza Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping |
topic_facet |
Motion correction Image registration Quantitative myocardial tissue characterization Myocardial T |
description |
Background: To evaluate and quantify the impact of a novel image-based motion correction technique in myocardial T2 mapping in terms of measurement reproducibility and spatial variability. Methods: Twelve healthy adult subjects were imaged using breath-hold (BH), free breathing (FB), and free breathing with respiratory navigator gating (FB + NAV) myocardial T2 mapping sequences. Fifty patients referred for clinical CMR were imaged using the FB + NAV sequence. All sequences used a T2 prepared (T2prep) steady-state free precession acquisition. In-plane myocardial motion was corrected using an adaptive registration of varying contrast-weighted images for improved tissue characterization (ARCTIC). DICE similarity coefficient (DSC) and myocardial boundary errors (MBE) were measured to quantify the motion estimation accuracy in healthy subjects. T2 mapping reproducibility and spatial variability were evaluated in healthy subjects using 5 repetitions of the FB + NAV sequence with either 4 or 20 T2prep echo times (TE). Subjective T2 map quality was assessed in patients by an experienced reader using a 4-point scale (1-non diagnostic, 4-excellent). Results: ARCTIC led to increased DSC in BH data (0.85 ± 0.08 vs. 0.90 ± 0.02, p = 0.007), FB data (0.78 ± 0.13 vs. 0.90 ± 0.21, p < 0.001), and FB + NAV data (0.86 ± 0.05 vs. 0.90 ± 0.02, p = 0.002), and reduced MBE in BH data (0.90 ± 0.40 vs. 0.64 ± 0.19 mm, p = 0.005), FB data (1.21 ± 0.65 vs. 0.63 ± 0.10 mm, p < 0.001), and FB + NAV data (0.81 ± 0.21 vs. 0.63 ± 0.08 mm, p < 0.001). Improved reproducibility (4TE: 5.3 ± 2.5 ms vs. 4.0 ± 1.5 ms, p = 0.016; 20TE: 3.9 ± 2.3 ms vs. 2.2 ± 0.5 ms, p = 0.002), reduced spatial variability (4TE: 12.8 ± 3.5 ms vs. 10.3 ± 2.5 ms, p < 0.001; 20TE: 9.7 ± 3.5 ms vs. 7.5 ± 1.4 ms) and improved subjective score of T2 map quality (3.43 ± 0.79 vs. 3.69 ± 0.55, p < 0.001) were obtained using ARCTIC. Conclusions: The ARCTIC technique substantially reduces spatial mis-alignment among T2-weighted images and improves the reproducibility and spatial variability of in-vivo T2 mapping. Version of Record |
format |
Article in Journal/Newspaper |
author |
Roujol, Sébastien Basha, Tamer A. Weingärtner, Sebastian Akçakaya, Mehmet Berg, Sophie Manning, Warren J. Nezafat, Reza |
author_facet |
Roujol, Sébastien Basha, Tamer A. Weingärtner, Sebastian Akçakaya, Mehmet Berg, Sophie Manning, Warren J. Nezafat, Reza |
author_sort |
Roujol, Sébastien |
title |
Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping |
title_short |
Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping |
title_full |
Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping |
title_fullStr |
Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping |
title_full_unstemmed |
Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping |
title_sort |
impact of motion correction on reproducibility and spatial variability of quantitative myocardial t2 mapping |
publisher |
BioMed Central |
publishDate |
2015 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295773 https://doi.org/10.1186/s12968-015-0141-1 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
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Arctic |
op_relation |
doi:10.1186/s12968-015-0141-1 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465156/pdf/ Journal of Cardiovascular Magnetic Resonance Roujol, Sébastien, Tamer A. Basha, Sebastian Weingärtner, Mehmet Akçakaya, Sophie Berg, Warren J. Manning, and Reza Nezafat. 2015. “Impact of motion correction on reproducibility and spatial variability of quantitative myocardial T2 mapping.” Journal of Cardiovascular Magnetic Resonance 17 (1): 46. doi:10.1186/s12968-015-0141-1. http://dx.doi.org/10.1186/s12968-015-0141-1. 1097-6647 http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295773 |
op_doi |
https://doi.org/10.1186/s12968-015-0141-1 |
container_title |
Journal of Cardiovascular Magnetic Resonance |
container_volume |
17 |
container_issue |
1 |
_version_ |
1766326173961289728 |