The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal
Mammals vary dramatically in lifespan, by at least two-orders of magnitude, but the molecular basis for this difference remains largely unknown. The bowhead whale Balaena mysticetus is the longest-lived mammal known, with an estimated maximal lifespan in excess of two hundred years. It is also one o...
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ftharvardudash:oai:dash.harvard.edu:1/13581028 2023-05-15T15:35:57+02:00 The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal Seim, Inge Ma, Siming Zhou, Xuming Gerashchenko, Maxim V. Lee, Sang-Goo Suydam, Robert George, John C. Bickham, John W. Gladyshev, Vadim N. 2014 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581028 en_US eng Impact Journals LLC http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247388/pdf/ Aging (Albany NY) Seim, Inge, Siming Ma, Xuming Zhou, Maxim V. Gerashchenko, Sang-Goo Lee, Robert Suydam, John C. George, John W. Bickham, and Vadim N. Gladyshev. 2014. “The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal.” Aging (Albany NY) 6 (10): 879-899. 1945-4589 http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581028 bowhead whale transcriptome insulin/IGF1-axis aging evolution Journal Article 2014 ftharvardudash 2022-04-05T06:47:00Z Mammals vary dramatically in lifespan, by at least two-orders of magnitude, but the molecular basis for this difference remains largely unknown. The bowhead whale Balaena mysticetus is the longest-lived mammal known, with an estimated maximal lifespan in excess of two hundred years. It is also one of the two largest animals and the most cold-adapted baleen whale species. Here, we report the first genome-wide gene expression analyses of the bowhead whale, based on the de novo assembly of its transcriptome. Bowhead whale or cetacean-specific changes in gene expression were identified in the liver, kidney and heart, and complemented with analyses of positively selected genes. Changes associated with altered insulin signaling and other gene expression patterns could help explain the remarkable longevity of bowhead whales as well as their adaptation to a lipid-rich diet. The data also reveal parallels in candidate longevity adaptations of the bowhead whale, naked mole rat and Brandt's bat. The bowhead whale transcriptome is a valuable resource for the study of this remarkable animal, including the evolution of longevity and its important correlates such as resistance to cancer and other diseases. Version of Record Article in Journal/Newspaper Balaena mysticetus baleen whale bowhead whale Harvard University: DASH - Digital Access to Scholarship at Harvard |
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Open Polar |
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Harvard University: DASH - Digital Access to Scholarship at Harvard |
op_collection_id |
ftharvardudash |
language |
English |
topic |
bowhead whale transcriptome insulin/IGF1-axis aging evolution |
spellingShingle |
bowhead whale transcriptome insulin/IGF1-axis aging evolution Seim, Inge Ma, Siming Zhou, Xuming Gerashchenko, Maxim V. Lee, Sang-Goo Suydam, Robert George, John C. Bickham, John W. Gladyshev, Vadim N. The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal |
topic_facet |
bowhead whale transcriptome insulin/IGF1-axis aging evolution |
description |
Mammals vary dramatically in lifespan, by at least two-orders of magnitude, but the molecular basis for this difference remains largely unknown. The bowhead whale Balaena mysticetus is the longest-lived mammal known, with an estimated maximal lifespan in excess of two hundred years. It is also one of the two largest animals and the most cold-adapted baleen whale species. Here, we report the first genome-wide gene expression analyses of the bowhead whale, based on the de novo assembly of its transcriptome. Bowhead whale or cetacean-specific changes in gene expression were identified in the liver, kidney and heart, and complemented with analyses of positively selected genes. Changes associated with altered insulin signaling and other gene expression patterns could help explain the remarkable longevity of bowhead whales as well as their adaptation to a lipid-rich diet. The data also reveal parallels in candidate longevity adaptations of the bowhead whale, naked mole rat and Brandt's bat. The bowhead whale transcriptome is a valuable resource for the study of this remarkable animal, including the evolution of longevity and its important correlates such as resistance to cancer and other diseases. Version of Record |
format |
Article in Journal/Newspaper |
author |
Seim, Inge Ma, Siming Zhou, Xuming Gerashchenko, Maxim V. Lee, Sang-Goo Suydam, Robert George, John C. Bickham, John W. Gladyshev, Vadim N. |
author_facet |
Seim, Inge Ma, Siming Zhou, Xuming Gerashchenko, Maxim V. Lee, Sang-Goo Suydam, Robert George, John C. Bickham, John W. Gladyshev, Vadim N. |
author_sort |
Seim, Inge |
title |
The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal |
title_short |
The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal |
title_full |
The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal |
title_fullStr |
The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal |
title_full_unstemmed |
The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal |
title_sort |
transcriptome of the bowhead whale balaena mysticetus reveals adaptations of the longest-lived mammal |
publisher |
Impact Journals LLC |
publishDate |
2014 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581028 |
genre |
Balaena mysticetus baleen whale bowhead whale |
genre_facet |
Balaena mysticetus baleen whale bowhead whale |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247388/pdf/ Aging (Albany NY) Seim, Inge, Siming Ma, Xuming Zhou, Maxim V. Gerashchenko, Sang-Goo Lee, Robert Suydam, John C. George, John W. Bickham, and Vadim N. Gladyshev. 2014. “The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal.” Aging (Albany NY) 6 (10): 879-899. 1945-4589 http://nrs.harvard.edu/urn-3:HUL.InstRepos:13581028 |
_version_ |
1766366298305986560 |