Estimation of Newborn Risk for Child or Adolescent Obesity: Lessons from Longitudinal Birth Cohorts

• Published in: PLoS ONE
• Main Authors: Morandi, Anita, Meyre, David, Lobbens, Stéphane, Kaakinen, Marika, Vatin, Vincent, Gaget, Stefan, Pouta, Anneli, Hartikainen, Anna-Liisa, Laitinen, Jaana, Ruokonen, Aimo, Das, Shikta, Khan, Anokhi Ali, Elliott, Paul, Maffeis, Claudio, Järvelin, Marjo-Riitta, Froguel, Philippe, Kleinman, Ken Paul, Rifas-Shiman, Sheryl Lynn, Gillman, Matthew William
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science 2012
• Subjects: Medicine; Clinical Genetics; Clinical Research Design; Cohort Studies; Endocrinology; Pediatric Endocrinology; Epidemiology; Cardiovascular Disease Epidemiology; Pediatric Epidemiology; Non-Clinical Medicine; Health Care Policy; Health Risk Analysis; Nutrition; Obesity; Pediatrics; Neonatology; Northern Finland
• Online Access: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10612548; https://doi.org/10.1371/journal.pone.0049919

Objectives: Prevention of obesity should start as early as possible after birth. We aimed to build clinically useful equations estimating the risk of later obesity in newborns, as a first step towards focused early prevention against the global obesity epidemic. Methods: We analyzed the lifetime Northern Finland Birth Cohort 1986 (NFBC1986) (N = 4,032) to draw predictive equations for childhood and adolescent obesity from traditional risk factors (parental BMI, birth weight, maternal gestational weight gain, behaviour and social indicators), and a genetic score built from 39 BMI/obesity-associated polymorphisms. We performed validation analyses in a retrospective cohort of 1,503 Italian children and in a prospective cohort of 1,032 U.S. children. Results: In the NFBC1986, the cumulative accuracy of traditional risk factors predicting childhood obesity, adolescent obesity, and childhood obesity persistent into adolescence was good: AUROC = 0·78[0·74–0.82], 0·75[0·71–0·79] and 0·85[0·80–0·90] respectively (all p<0·001). Adding the genetic score produced discrimination improvements ≤1%. The NFBC1986 equation for childhood obesity remained acceptably accurate when applied to the Italian and the U.S. cohort (AUROC = 0·70[0·63–0·77] and 0·73[0·67–0·80] respectively) and the two additional equations for childhood obesity newly drawn from the Italian and the U.S. datasets showed good accuracy in respective cohorts (AUROC = 0·74[0·69–0·79] and 0·79[0·73–0·84]) (all p<0·001). The three equations for childhood obesity were converted into simple Excel risk calculators for potential clinical use. Conclusion: This study provides the first example of handy tools for predicting childhood obesity in newborns by means of easily recorded information, while it shows that currently known genetic variants have very little usefulness for such prediction. Version of Record