Response Inhibition and Error Monitoring during a Visual Go/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury
Background: Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition. Objectives: In this study we examined the neurophysiological correlates of the response inhibition deficits associated with these exposures, using event...
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National Institute of Environmental Health Sciences
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ftharvardudash:oai:dash.harvard.edu:1/10364563 2023-05-15T15:16:29+02:00 Response Inhibition and Error Monitoring during a Visual Go/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury Boucher, Olivier Burden, Matthew J. Muckle, Gina Saint-Amour, Dave Ayotte, Pierre Dewailly, Éric Jacobson, Sandra W. Nelson, Charles A. Jacobson, Joseph L. 2012 application/pdf http://nrs.harvard.edu/urn-3:HUL.InstRepos:10364563 https://doi.org/10.1289/ehp.1103828 en_US eng National Institute of Environmental Health Sciences doi:10.1289/ehp.1103828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339450/pdf/ Environmental Health Perspectives Boucher, Olivier, Matthew J. Burden, Gina Muckle, Dave Saint-Amour, Pierre Ayotte, Éric Dewailly, Charles A. Nelson, Sandra W. Jacobson, and Joseph L. Jacobson. 2012. Response inhibition and error monitoring during a visual go/no-go task in Inuit children exposed to lead, polychlorinated biphenyls, and methylmercury. Environmental Health Perspectives 120(4): 608-615. 0091-6765 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10364563 event-related potentials error monitoring executive function lead methylmercury neurotoxicity polychlorinated biphenyls response inhibition Journal Article 2012 ftharvardudash https://doi.org/10.1289/ehp.1103828 2022-04-04T12:44:56Z Background: Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition. Objectives: In this study we examined the neurophysiological correlates of the response inhibition deficits associated with these exposures, using event-related potentials (ERPs) in a sample of school-age Inuit children from Arctic Québec exposed through their traditional diet. Methods: In a prospective longitudinal study, we assessed 196 children (mean age, 11.3 years) on a visual go/no-go response inhibition paradigm. Pb, PCB, and mercury (Hg) concentrations were analyzed in cord and current blood samples. Hierarchical multiple regression analyses were conducted to examine the associations of contaminant levels to go/no-go performance (mean reaction time, percent correct go, percent correct no-go) and five ERPs [N2, P3, error-related negativity, error positivity (Pe), and correct response positivity (Pc)] after control for confounding variables. Results: Current blood Pb concentrations were associated with higher rates of false alarms and with decreased P3 amplitudes to go and no-go trials. Current plasma PCB-153 concentrations were associated with slower reaction times and with reduced amplitudes of the Pe and Pc response-related potentials. Hg concentrations were not related to any outcome on this task but showed significant interactions with other contaminants on certain outcomes. Conclusions: These results suggest that Pb exposure during childhood impairs the child’s ability to allocate the cognitive resources needed to correctly inhibit a prepotent response, resulting in increased impulsivity. By contrast, postnatal PCB exposure appears to affect processes associated with error monitoring, an aspect of behavioral regulation required to adequately adapt to the changing demands of the environment, which results in reduced task efficiency.: Version of Record Article in Journal/Newspaper Arctic inuit Harvard University: DASH - Digital Access to Scholarship at Harvard Arctic Environmental Health Perspectives 120 4 608 615 |
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Open Polar |
collection |
Harvard University: DASH - Digital Access to Scholarship at Harvard |
op_collection_id |
ftharvardudash |
language |
English |
topic |
event-related potentials error monitoring executive function lead methylmercury neurotoxicity polychlorinated biphenyls response inhibition |
spellingShingle |
event-related potentials error monitoring executive function lead methylmercury neurotoxicity polychlorinated biphenyls response inhibition Boucher, Olivier Burden, Matthew J. Muckle, Gina Saint-Amour, Dave Ayotte, Pierre Dewailly, Éric Jacobson, Sandra W. Nelson, Charles A. Jacobson, Joseph L. Response Inhibition and Error Monitoring during a Visual Go/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury |
topic_facet |
event-related potentials error monitoring executive function lead methylmercury neurotoxicity polychlorinated biphenyls response inhibition |
description |
Background: Lead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition. Objectives: In this study we examined the neurophysiological correlates of the response inhibition deficits associated with these exposures, using event-related potentials (ERPs) in a sample of school-age Inuit children from Arctic Québec exposed through their traditional diet. Methods: In a prospective longitudinal study, we assessed 196 children (mean age, 11.3 years) on a visual go/no-go response inhibition paradigm. Pb, PCB, and mercury (Hg) concentrations were analyzed in cord and current blood samples. Hierarchical multiple regression analyses were conducted to examine the associations of contaminant levels to go/no-go performance (mean reaction time, percent correct go, percent correct no-go) and five ERPs [N2, P3, error-related negativity, error positivity (Pe), and correct response positivity (Pc)] after control for confounding variables. Results: Current blood Pb concentrations were associated with higher rates of false alarms and with decreased P3 amplitudes to go and no-go trials. Current plasma PCB-153 concentrations were associated with slower reaction times and with reduced amplitudes of the Pe and Pc response-related potentials. Hg concentrations were not related to any outcome on this task but showed significant interactions with other contaminants on certain outcomes. Conclusions: These results suggest that Pb exposure during childhood impairs the child’s ability to allocate the cognitive resources needed to correctly inhibit a prepotent response, resulting in increased impulsivity. By contrast, postnatal PCB exposure appears to affect processes associated with error monitoring, an aspect of behavioral regulation required to adequately adapt to the changing demands of the environment, which results in reduced task efficiency.: Version of Record |
format |
Article in Journal/Newspaper |
author |
Boucher, Olivier Burden, Matthew J. Muckle, Gina Saint-Amour, Dave Ayotte, Pierre Dewailly, Éric Jacobson, Sandra W. Nelson, Charles A. Jacobson, Joseph L. |
author_facet |
Boucher, Olivier Burden, Matthew J. Muckle, Gina Saint-Amour, Dave Ayotte, Pierre Dewailly, Éric Jacobson, Sandra W. Nelson, Charles A. Jacobson, Joseph L. |
author_sort |
Boucher, Olivier |
title |
Response Inhibition and Error Monitoring during a Visual Go/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury |
title_short |
Response Inhibition and Error Monitoring during a Visual Go/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury |
title_full |
Response Inhibition and Error Monitoring during a Visual Go/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury |
title_fullStr |
Response Inhibition and Error Monitoring during a Visual Go/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury |
title_full_unstemmed |
Response Inhibition and Error Monitoring during a Visual Go/No-Go Task in Inuit Children Exposed to Lead, Polychlorinated Biphenyls, and Methylmercury |
title_sort |
response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury |
publisher |
National Institute of Environmental Health Sciences |
publishDate |
2012 |
url |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10364563 https://doi.org/10.1289/ehp.1103828 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic inuit |
genre_facet |
Arctic inuit |
op_relation |
doi:10.1289/ehp.1103828 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339450/pdf/ Environmental Health Perspectives Boucher, Olivier, Matthew J. Burden, Gina Muckle, Dave Saint-Amour, Pierre Ayotte, Éric Dewailly, Charles A. Nelson, Sandra W. Jacobson, and Joseph L. Jacobson. 2012. Response inhibition and error monitoring during a visual go/no-go task in Inuit children exposed to lead, polychlorinated biphenyls, and methylmercury. Environmental Health Perspectives 120(4): 608-615. 0091-6765 http://nrs.harvard.edu/urn-3:HUL.InstRepos:10364563 |
op_doi |
https://doi.org/10.1289/ehp.1103828 |
container_title |
Environmental Health Perspectives |
container_volume |
120 |
container_issue |
4 |
container_start_page |
608 |
op_container_end_page |
615 |
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1766346775107469312 |