Innovative in silico approaches to address avian flu using grid technology
7 pages, submitted to Infectious Disorders - Drug Targets The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging dis...
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fthalin2p3:oai:HAL:in2p3-00347411v1 2024-05-12T08:01:25+00:00 Innovative in silico approaches to address avian flu using grid technology Breton, Vincent da Costa, A.L. de Vlieger, Paul Maigne, L. Sarramia, D. Kim, Y.-M. Kim, D. Nguyen, H.Q. Solomonides, T. Wu, Y.-T. N. Hai, T. Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC) Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) 2008 https://hal.in2p3.fr/in2p3-00347411 https://hal.in2p3.fr/in2p3-00347411/document https://hal.in2p3.fr/in2p3-00347411/file/Innovativ.pdf en eng HAL CCSD info:eu-repo/semantics/altIdentifier/arxiv/0812.4341 in2p3-00347411 https://hal.in2p3.fr/in2p3-00347411 https://hal.in2p3.fr/in2p3-00347411/document https://hal.in2p3.fr/in2p3-00347411/file/Innovativ.pdf ARXIV: 0812.4341 info:eu-repo/semantics/OpenAccess Infectious disorders drug targets https://hal.in2p3.fr/in2p3-00347411 Infectious disorders drug targets, 2008, 7 p avian flu grid surveillance network virtual screening molecular epidemiology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] info:eu-repo/semantics/article Journal articles 2008 fthalin2p3 2024-04-17T15:35:28Z 7 pages, submitted to Infectious Disorders - Drug Targets The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper presents how we are currently exploring how to integrate the existing data sources towards a global surveillance network for molecular epidemiology. Article in Journal/Newspaper Avian flu HAL-IN2P3 (Institut national de physique nucléaire et de physique des particules) |
institution |
Open Polar |
collection |
HAL-IN2P3 (Institut national de physique nucléaire et de physique des particules) |
op_collection_id |
fthalin2p3 |
language |
English |
topic |
avian flu grid surveillance network virtual screening molecular epidemiology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
spellingShingle |
avian flu grid surveillance network virtual screening molecular epidemiology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] Breton, Vincent da Costa, A.L. de Vlieger, Paul Maigne, L. Sarramia, D. Kim, Y.-M. Kim, D. Nguyen, H.Q. Solomonides, T. Wu, Y.-T. N. Hai, T. Innovative in silico approaches to address avian flu using grid technology |
topic_facet |
avian flu grid surveillance network virtual screening molecular epidemiology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
description |
7 pages, submitted to Infectious Disorders - Drug Targets The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper presents how we are currently exploring how to integrate the existing data sources towards a global surveillance network for molecular epidemiology. |
author2 |
Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC) Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
Breton, Vincent da Costa, A.L. de Vlieger, Paul Maigne, L. Sarramia, D. Kim, Y.-M. Kim, D. Nguyen, H.Q. Solomonides, T. Wu, Y.-T. N. Hai, T. |
author_facet |
Breton, Vincent da Costa, A.L. de Vlieger, Paul Maigne, L. Sarramia, D. Kim, Y.-M. Kim, D. Nguyen, H.Q. Solomonides, T. Wu, Y.-T. N. Hai, T. |
author_sort |
Breton, Vincent |
title |
Innovative in silico approaches to address avian flu using grid technology |
title_short |
Innovative in silico approaches to address avian flu using grid technology |
title_full |
Innovative in silico approaches to address avian flu using grid technology |
title_fullStr |
Innovative in silico approaches to address avian flu using grid technology |
title_full_unstemmed |
Innovative in silico approaches to address avian flu using grid technology |
title_sort |
innovative in silico approaches to address avian flu using grid technology |
publisher |
HAL CCSD |
publishDate |
2008 |
url |
https://hal.in2p3.fr/in2p3-00347411 https://hal.in2p3.fr/in2p3-00347411/document https://hal.in2p3.fr/in2p3-00347411/file/Innovativ.pdf |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
Infectious disorders drug targets https://hal.in2p3.fr/in2p3-00347411 Infectious disorders drug targets, 2008, 7 p |
op_relation |
info:eu-repo/semantics/altIdentifier/arxiv/0812.4341 in2p3-00347411 https://hal.in2p3.fr/in2p3-00347411 https://hal.in2p3.fr/in2p3-00347411/document https://hal.in2p3.fr/in2p3-00347411/file/Innovativ.pdf ARXIV: 0812.4341 |
op_rights |
info:eu-repo/semantics/OpenAccess |
_version_ |
1798843558768148480 |