Seasonal changes in eicosanoid metabolism in the brown bear
International audience Polyunsaturated fatty acids (PUFAs) exert several important functions across organ systems. During winter, hibernators divert PUFAs from oxidation, retaining them in their tissues and membranes, to ensure proper body functions at low body temperature. PUFAs are also precursors...
Published in: | The Science of Nature |
---|---|
Main Authors: | , , , , , , , , , , , |
Other Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2018
|
Subjects: | |
Online Access: | https://hal.science/hal-01907890 https://doi.org/10.1007/s00114-018-1583-8 |
id |
fthalin2p3:oai:HAL:hal-01907890v1 |
---|---|
record_format |
openpolar |
institution |
Open Polar |
collection |
HAL-IN2P3 (Institut national de physique nucléaire et de physique des particules) |
op_collection_id |
fthalin2p3 |
language |
English |
topic |
Hibernation Metabolism Fatty acids Prostaglandins Thromboxane Leukotriene [SDE]Environmental Sciences |
spellingShingle |
Hibernation Metabolism Fatty acids Prostaglandins Thromboxane Leukotriene [SDE]Environmental Sciences Giroud, Sylvain Evans, Alina, M Chery, Isabelle Bertile, Fabrice Tascher, Georg Bertrand-Michel, Justine Gauquelin-Koch, Guillemette Arnemo, Jon, M Swenson, Jon, M Lefai, Etienne Blanc, Stéphane Simon, Chantal Seasonal changes in eicosanoid metabolism in the brown bear |
topic_facet |
Hibernation Metabolism Fatty acids Prostaglandins Thromboxane Leukotriene [SDE]Environmental Sciences |
description |
International audience Polyunsaturated fatty acids (PUFAs) exert several important functions across organ systems. During winter, hibernators divert PUFAs from oxidation, retaining them in their tissues and membranes, to ensure proper body functions at low body temperature. PUFAs are also precursors of eicosanoids with pro- and anti-inflammatory properties. This study investigated seasonal changes in eicosanoid metabolism of free-ranging brown bears (Ursus arctos). By using a lipidomic approach, we assessed (1) levels of specific omega-3 and omega-6 fatty acids involved in the eicosanoid cascade and (2) concentrations of eicosanoids in skeletal muscle and blood plasma of winter hibernating and summer active bears. We observed significant seasonal changes in the specific omega-3 and omega-6 precursors. We also found significant seasonal alterations of eicosanoid levels in both tissues. Concentrations of pro-inflammatory eicosanoids, such as thromboxane B2, 5-hydroxyeicosatetraenoic acid (HETE), and 15-HETE and 18-HETE, were significantly lower in muscle and/or plasma of hibernating bears compared to summer-active animals. Further, plasma and muscle levels of 5,6-epoxyeicosatrienoic acid (EET), as well as muscle concentration of 8,9-EET, tended to be lower in bears during winter hibernation vs. summer. We also found lower plasma levels of anti-inflammatory eicosanoids, such as 15dPGJ(2) and PGE(3), in bears during winter hibernation. Despite of the limited changes in omega-3 and omega-6 precursors, plasma and muscle concentrations of the products of all pathways decreased significantly, or remained unchanged, independent of their pro- or anti-inflammatory properties. These findings suggest that hibernation in bears is associated with a depressed state of the eicosanoid cascade. |
author2 |
Department of Integrative Biology and Evolution, Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna Department of Forestry and Wildlife Management Hedmark University College Département Ecologie, Physiologie et Ethologie (DEPE-IPHC) Institut Pluridisciplinaire Hubert Curien (IPHC) Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC) MetaToul Lipidomics Institut des Maladies Métaboliques et Cardiovasculaires (I2MC) Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-MetaboHUB-MetaToul MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL) Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) Institut National Polytechnique (Toulouse) (Toulouse INP) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire de Toulouse (ENVT) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Centre National d'Études Spatiales Toulouse (CNES) Norwegian Institute for Nature Research (NINA) Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) Norwegian Environmental Agency; Swedish Environmental Protection Agency; Polish-Norwegian Research Program POL-NOR/198352/85/2013; Austrian Science Fund (FWF) P27267-B25 |
format |
Article in Journal/Newspaper |
author |
Giroud, Sylvain Evans, Alina, M Chery, Isabelle Bertile, Fabrice Tascher, Georg Bertrand-Michel, Justine Gauquelin-Koch, Guillemette Arnemo, Jon, M Swenson, Jon, M Lefai, Etienne Blanc, Stéphane Simon, Chantal |
author_facet |
Giroud, Sylvain Evans, Alina, M Chery, Isabelle Bertile, Fabrice Tascher, Georg Bertrand-Michel, Justine Gauquelin-Koch, Guillemette Arnemo, Jon, M Swenson, Jon, M Lefai, Etienne Blanc, Stéphane Simon, Chantal |
author_sort |
Giroud, Sylvain |
title |
Seasonal changes in eicosanoid metabolism in the brown bear |
title_short |
Seasonal changes in eicosanoid metabolism in the brown bear |
title_full |
Seasonal changes in eicosanoid metabolism in the brown bear |
title_fullStr |
Seasonal changes in eicosanoid metabolism in the brown bear |
title_full_unstemmed |
Seasonal changes in eicosanoid metabolism in the brown bear |
title_sort |
seasonal changes in eicosanoid metabolism in the brown bear |
publisher |
HAL CCSD |
publishDate |
2018 |
url |
https://hal.science/hal-01907890 https://doi.org/10.1007/s00114-018-1583-8 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
ISSN: 0028-1042 EISSN: 1432-1904 The Science of Nature Naturwissenschaften https://hal.science/hal-01907890 The Science of Nature Naturwissenschaften, 2018, 105 (9-10), ⟨10.1007/s00114-018-1583-8⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00114-018-1583-8 info:eu-repo/semantics/altIdentifier/pmid/30291454 hal-01907890 https://hal.science/hal-01907890 doi:10.1007/s00114-018-1583-8 PRODINRA: 455432 PUBMED: 30291454 PUBMEDCENTRAL: PMC6182652 WOS: 000446551000008 |
op_doi |
https://doi.org/10.1007/s00114-018-1583-8 |
container_title |
The Science of Nature |
container_volume |
105 |
container_issue |
9-10 |
_version_ |
1798834557797007360 |
spelling |
fthalin2p3:oai:HAL:hal-01907890v1 2024-05-12T08:12:15+00:00 Seasonal changes in eicosanoid metabolism in the brown bear Giroud, Sylvain Evans, Alina, M Chery, Isabelle Bertile, Fabrice Tascher, Georg Bertrand-Michel, Justine Gauquelin-Koch, Guillemette Arnemo, Jon, M Swenson, Jon, M Lefai, Etienne Blanc, Stéphane Simon, Chantal Department of Integrative Biology and Evolution, Research Institute of Wildlife Ecology, University of Veterinary Medicine Vienna Department of Forestry and Wildlife Management Hedmark University College Département Ecologie, Physiologie et Ethologie (DEPE-IPHC) Institut Pluridisciplinaire Hubert Curien (IPHC) Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC) MetaToul Lipidomics Institut des Maladies Métaboliques et Cardiovasculaires (I2MC) Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-MetaboHUB-MetaToul MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL) Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) Institut National Polytechnique (Toulouse) (Toulouse INP) Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-MetaboHUB-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire de Toulouse (ENVT) Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Centre National d'Études Spatiales Toulouse (CNES) Norwegian Institute for Nature Research (NINA) Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) Norwegian Environmental Agency; Swedish Environmental Protection Agency; Polish-Norwegian Research Program POL-NOR/198352/85/2013; Austrian Science Fund (FWF) P27267-B25 2018-10 https://hal.science/hal-01907890 https://doi.org/10.1007/s00114-018-1583-8 en eng HAL CCSD Springer Verlag info:eu-repo/semantics/altIdentifier/doi/10.1007/s00114-018-1583-8 info:eu-repo/semantics/altIdentifier/pmid/30291454 hal-01907890 https://hal.science/hal-01907890 doi:10.1007/s00114-018-1583-8 PRODINRA: 455432 PUBMED: 30291454 PUBMEDCENTRAL: PMC6182652 WOS: 000446551000008 ISSN: 0028-1042 EISSN: 1432-1904 The Science of Nature Naturwissenschaften https://hal.science/hal-01907890 The Science of Nature Naturwissenschaften, 2018, 105 (9-10), ⟨10.1007/s00114-018-1583-8⟩ Hibernation Metabolism Fatty acids Prostaglandins Thromboxane Leukotriene [SDE]Environmental Sciences info:eu-repo/semantics/article Journal articles 2018 fthalin2p3 https://doi.org/10.1007/s00114-018-1583-8 2024-04-17T15:48:14Z International audience Polyunsaturated fatty acids (PUFAs) exert several important functions across organ systems. During winter, hibernators divert PUFAs from oxidation, retaining them in their tissues and membranes, to ensure proper body functions at low body temperature. PUFAs are also precursors of eicosanoids with pro- and anti-inflammatory properties. This study investigated seasonal changes in eicosanoid metabolism of free-ranging brown bears (Ursus arctos). By using a lipidomic approach, we assessed (1) levels of specific omega-3 and omega-6 fatty acids involved in the eicosanoid cascade and (2) concentrations of eicosanoids in skeletal muscle and blood plasma of winter hibernating and summer active bears. We observed significant seasonal changes in the specific omega-3 and omega-6 precursors. We also found significant seasonal alterations of eicosanoid levels in both tissues. Concentrations of pro-inflammatory eicosanoids, such as thromboxane B2, 5-hydroxyeicosatetraenoic acid (HETE), and 15-HETE and 18-HETE, were significantly lower in muscle and/or plasma of hibernating bears compared to summer-active animals. Further, plasma and muscle levels of 5,6-epoxyeicosatrienoic acid (EET), as well as muscle concentration of 8,9-EET, tended to be lower in bears during winter hibernation vs. summer. We also found lower plasma levels of anti-inflammatory eicosanoids, such as 15dPGJ(2) and PGE(3), in bears during winter hibernation. Despite of the limited changes in omega-3 and omega-6 precursors, plasma and muscle concentrations of the products of all pathways decreased significantly, or remained unchanged, independent of their pro- or anti-inflammatory properties. These findings suggest that hibernation in bears is associated with a depressed state of the eicosanoid cascade. Article in Journal/Newspaper Ursus arctos HAL-IN2P3 (Institut national de physique nucléaire et de physique des particules) The Science of Nature 105 9-10 |