Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats
Carbendazim is a systemic broad-spectrum fungicide controlling a wide range of pathogens. it is also used as a preservative in paint, textile, papermaking and leather industry, as well as a preservative of fruits. In the present study, carbendazim was administered at 0, 150, 300 and 600 mg/kg per da...
Published in: | Human & Experimental Toxicology |
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Language: | English |
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2001
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Online Access: | https://doi.org/10.1191/096032701718890603 https://avesis.hacettepe.edu.tr/publication/details/785a670f-977f-4930-9060-e9830ff35884/oai |
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fthacettepeuniav:785a670f-977f-4930-9060-e9830ff35884 2023-05-15T18:05:23+02:00 Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats Barlas, NURHAYAT SELMANOGLU, GÜLDENİZ SONGUR, S KOCKAYA, EA 2001-12-01T01:00:00Z https://doi.org/10.1191/096032701718890603 https://avesis.hacettepe.edu.tr/publication/details/785a670f-977f-4930-9060-e9830ff35884/oai eng eng 785a670f-977f-4930-9060-e9830ff35884 doi:10.1191/096032701718890603 https://avesis.hacettepe.edu.tr/publication/details/785a670f-977f-4930-9060-e9830ff35884/oai info:eu-repo/semantics/closedAccess info:eu-repo/semantics/article 2001 fthacettepeuniav https://doi.org/10.1191/096032701718890603 2022-12-13T11:08:17Z Carbendazim is a systemic broad-spectrum fungicide controlling a wide range of pathogens. it is also used as a preservative in paint, textile, papermaking and leather industry, as well as a preservative of fruits. In the present study, carbendazim was administered at 0, 150, 300 and 600 mg/kg per day doses orally to male rats (Rattus rattus) for 15 weeks. At the end of the experiment, blood samples, liver and kidney tissues of each animal were taken. Serum enzyme activities, and haematological and biochemical parameters were analysed. In toxicological tests, 600 mg/kg per day doses of carbendazim caused an increase of albumin, glucose, creatinine and cholesterol levels. Also, at the same doses, white blood cell and lymphocyte counts decreased. However, mean cell hemoglobin and mean cell hemoglobin concentrations increased. Histopathological examinations revealed congestion, an enlargement of the sinusoids, an increase in the number of Kupffer cells, mononuclear cell infiltration and hydropic degeneration in the liver. At the highest doses, congestion, mononuclear cell infiltration, tubular degeneration and fibrosis were observed in the kidney tissue. These results indicate that 300 and 600 mg/kg per day carbendazim affected the liver and kidney tissue and caused some changes on haematological and biochemical parameters of rats. Article in Journal/Newspaper Rattus rattus Hacettepe University Research Information System Human & Experimental Toxicology 20 12 625 630 |
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Hacettepe University Research Information System |
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fthacettepeuniav |
language |
English |
description |
Carbendazim is a systemic broad-spectrum fungicide controlling a wide range of pathogens. it is also used as a preservative in paint, textile, papermaking and leather industry, as well as a preservative of fruits. In the present study, carbendazim was administered at 0, 150, 300 and 600 mg/kg per day doses orally to male rats (Rattus rattus) for 15 weeks. At the end of the experiment, blood samples, liver and kidney tissues of each animal were taken. Serum enzyme activities, and haematological and biochemical parameters were analysed. In toxicological tests, 600 mg/kg per day doses of carbendazim caused an increase of albumin, glucose, creatinine and cholesterol levels. Also, at the same doses, white blood cell and lymphocyte counts decreased. However, mean cell hemoglobin and mean cell hemoglobin concentrations increased. Histopathological examinations revealed congestion, an enlargement of the sinusoids, an increase in the number of Kupffer cells, mononuclear cell infiltration and hydropic degeneration in the liver. At the highest doses, congestion, mononuclear cell infiltration, tubular degeneration and fibrosis were observed in the kidney tissue. These results indicate that 300 and 600 mg/kg per day carbendazim affected the liver and kidney tissue and caused some changes on haematological and biochemical parameters of rats. |
format |
Article in Journal/Newspaper |
author |
Barlas, NURHAYAT SELMANOGLU, GÜLDENİZ SONGUR, S KOCKAYA, EA |
spellingShingle |
Barlas, NURHAYAT SELMANOGLU, GÜLDENİZ SONGUR, S KOCKAYA, EA Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
author_facet |
Barlas, NURHAYAT SELMANOGLU, GÜLDENİZ SONGUR, S KOCKAYA, EA |
author_sort |
Barlas, NURHAYAT |
title |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_short |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_full |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_fullStr |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_full_unstemmed |
Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
title_sort |
carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats |
publishDate |
2001 |
url |
https://doi.org/10.1191/096032701718890603 https://avesis.hacettepe.edu.tr/publication/details/785a670f-977f-4930-9060-e9830ff35884/oai |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
785a670f-977f-4930-9060-e9830ff35884 doi:10.1191/096032701718890603 https://avesis.hacettepe.edu.tr/publication/details/785a670f-977f-4930-9060-e9830ff35884/oai |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1191/096032701718890603 |
container_title |
Human & Experimental Toxicology |
container_volume |
20 |
container_issue |
12 |
container_start_page |
625 |
op_container_end_page |
630 |
_version_ |
1766176857511690240 |