The unsolved problem of otitis media in indigenous populations: A systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media
Background: Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence. We co...
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ftgriffithuniv:oai:research-repository.griffith.edu.au:10072/383558 2023-05-15T16:29:59+02:00 The unsolved problem of otitis media in indigenous populations: A systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media Coleman, A Wood, A Bialasiewicz, S Ware, Robert Marsh, R Cervin, A 2018 application/octet-stream http://hdl.handle.net/10072/383558 https://doi.org/10.1186/s40168-018-0577-2 unknown Microbiome http://creativecommons.org/licenses/by/4.0/ © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. CC-BY CC0 PDM Ecology Journal article 2018 ftgriffithuniv https://doi.org/10.1186/s40168-018-0577-2 2019-05-20T22:22:42Z Background: Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence. We conducted a systematic review of the literature exploring the upper airway and middle ear microbiota in relation to OM in indigenous children. Methods: Papers targeting microbiota in relation to OM in children < 18 years indigenous to Australia, New Zealand, North America, and Greenland were sought. MEDLINE, CINAHL, EMBASE, Cochrane Library, and Informit databases were searched using key words. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA guidelines. Results: Twenty-five papers considering indigenous Australian, Alaskan, and Greenlandic children were included. There were high rates of nasopharyngeal colonization with the three main otopathogens (Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis) in indigenous children with OM. Middle ear samples had lower rates of otopathogen detection, although detection rates increased when molecular methods were used. Pseudomonas aeruginosa and Staphylococcus aureus were commonly detected in middle ear discharge of children with chronic suppurative OM. There was a significant heterogeneity between studies, particularly in microbiological methods, which were largely limited to culture-based detection of the main otopathogens. Conclusions: There are high rates of otopathogen colonization in indigenous children with OM. Chronic suppurative OM appears to be associated with a different microbial profile. Beyond the main otopathogens, the data are limited. Further research is required to explore the entire upper respiratory tract/middle ear microbiota in relation to OM, with the inclusion of healthy indigenous peers as controls. Full Text Article in Journal/Newspaper Greenland greenlandic Griffith University: Griffith Research Online Greenland New Zealand Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) Microbiome 6 1 |
institution |
Open Polar |
collection |
Griffith University: Griffith Research Online |
op_collection_id |
ftgriffithuniv |
language |
unknown |
topic |
Ecology |
spellingShingle |
Ecology Coleman, A Wood, A Bialasiewicz, S Ware, Robert Marsh, R Cervin, A The unsolved problem of otitis media in indigenous populations: A systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media |
topic_facet |
Ecology |
description |
Background: Otitis media (OM) imposes a great burden of disease in indigenous populations around the world, despite a variety of treatment and prevention programs. Improved understanding of the pathogenesis of OM in indigenous populations is required to advance treatment and reduce prevalence. We conducted a systematic review of the literature exploring the upper airway and middle ear microbiota in relation to OM in indigenous children. Methods: Papers targeting microbiota in relation to OM in children < 18 years indigenous to Australia, New Zealand, North America, and Greenland were sought. MEDLINE, CINAHL, EMBASE, Cochrane Library, and Informit databases were searched using key words. Two independent reviewers screened titles, abstracts, and then full-text papers against inclusion criteria according to PRISMA guidelines. Results: Twenty-five papers considering indigenous Australian, Alaskan, and Greenlandic children were included. There were high rates of nasopharyngeal colonization with the three main otopathogens (Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis) in indigenous children with OM. Middle ear samples had lower rates of otopathogen detection, although detection rates increased when molecular methods were used. Pseudomonas aeruginosa and Staphylococcus aureus were commonly detected in middle ear discharge of children with chronic suppurative OM. There was a significant heterogeneity between studies, particularly in microbiological methods, which were largely limited to culture-based detection of the main otopathogens. Conclusions: There are high rates of otopathogen colonization in indigenous children with OM. Chronic suppurative OM appears to be associated with a different microbial profile. Beyond the main otopathogens, the data are limited. Further research is required to explore the entire upper respiratory tract/middle ear microbiota in relation to OM, with the inclusion of healthy indigenous peers as controls. Full Text |
format |
Article in Journal/Newspaper |
author |
Coleman, A Wood, A Bialasiewicz, S Ware, Robert Marsh, R Cervin, A |
author_facet |
Coleman, A Wood, A Bialasiewicz, S Ware, Robert Marsh, R Cervin, A |
author_sort |
Coleman, A |
title |
The unsolved problem of otitis media in indigenous populations: A systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media |
title_short |
The unsolved problem of otitis media in indigenous populations: A systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media |
title_full |
The unsolved problem of otitis media in indigenous populations: A systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media |
title_fullStr |
The unsolved problem of otitis media in indigenous populations: A systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media |
title_full_unstemmed |
The unsolved problem of otitis media in indigenous populations: A systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media |
title_sort |
unsolved problem of otitis media in indigenous populations: a systematic review of upper respiratory and middle ear microbiology in indigenous children with otitis media |
publishDate |
2018 |
url |
http://hdl.handle.net/10072/383558 https://doi.org/10.1186/s40168-018-0577-2 |
long_lat |
ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
geographic |
Greenland New Zealand Prisma |
geographic_facet |
Greenland New Zealand Prisma |
genre |
Greenland greenlandic |
genre_facet |
Greenland greenlandic |
op_relation |
Microbiome |
op_rights |
http://creativecommons.org/licenses/by/4.0/ © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
op_rightsnorm |
CC-BY CC0 PDM |
op_doi |
https://doi.org/10.1186/s40168-018-0577-2 |
container_title |
Microbiome |
container_volume |
6 |
container_issue |
1 |
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1766019687171227648 |