Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment
Persistent Organic Pollutants (POPs) are predominantly anthropogenically-derived chemicals, characterized by their persistence, toxicity, capacity for bioaccumulation and tendency for long-range environmental transport. They have been observed at elevated concentrations in polar environments and bio...
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ftgriffithuniv:oai:research-repository.griffith.edu.au:10072/367059 2023-05-15T13:43:49+02:00 Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment Burkard, Michael Susan Bengtson Nash Roger Cropp Deanne Whitworth Kristin Schirmer 2017 application/pdf http://hdl.handle.net/10072/367059 English eng Griffith University Persistent organic pollutants Anthropogenically-derived chemicals Humpback whales (Megaptera novaeangliae) Fibroblast cell culture Griffith thesis 2017 ftgriffithuniv 2018-07-30T11:02:00Z Persistent Organic Pollutants (POPs) are predominantly anthropogenically-derived chemicals, characterized by their persistence, toxicity, capacity for bioaccumulation and tendency for long-range environmental transport. They have been observed at elevated concentrations in polar environments and biota, including Antarctic foraging humpback whales (Megaptera novaeangliae). Southern hemisphere humpback whales are highly dependent on lipid reserves accumulated during summer feeding to sustain their seasonal migration and associated period of voluntary fasting, the longest known in any mammal. This extreme life-history behaviour has been observed to result in a dramatic increase in blubber POP concentrations and presumed circulating lipophilic POP burdens during times of negative energy balance. Toxicological investigations of the effect of circulating POP burdens are, however, constrained by logistical challenges associated with large cetacean research, and the limitations of existing non-lethal research approaches.This thesis research was designed to develop a humpback whale derived fibroblast cell culture for species-specific assessment of the toxicological impact of priority POPs and other potential stressors. Thesis (PhD Doctorate) Doctor of Philosophy (PhD) Griffith School of Environemnt Science, Environment, Engineering and Technology Full Text Other/Unknown Material Antarc* Antarctic Humpback Whale Megaptera novaeangliae Griffith University: Griffith Research Online Antarctic Griffith ENVELOPE(-155.500,-155.500,-85.883,-85.883) |
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Open Polar |
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Griffith University: Griffith Research Online |
op_collection_id |
ftgriffithuniv |
language |
English |
topic |
Persistent organic pollutants Anthropogenically-derived chemicals Humpback whales (Megaptera novaeangliae) Fibroblast cell culture |
spellingShingle |
Persistent organic pollutants Anthropogenically-derived chemicals Humpback whales (Megaptera novaeangliae) Fibroblast cell culture Burkard, Michael Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment |
topic_facet |
Persistent organic pollutants Anthropogenically-derived chemicals Humpback whales (Megaptera novaeangliae) Fibroblast cell culture |
description |
Persistent Organic Pollutants (POPs) are predominantly anthropogenically-derived chemicals, characterized by their persistence, toxicity, capacity for bioaccumulation and tendency for long-range environmental transport. They have been observed at elevated concentrations in polar environments and biota, including Antarctic foraging humpback whales (Megaptera novaeangliae). Southern hemisphere humpback whales are highly dependent on lipid reserves accumulated during summer feeding to sustain their seasonal migration and associated period of voluntary fasting, the longest known in any mammal. This extreme life-history behaviour has been observed to result in a dramatic increase in blubber POP concentrations and presumed circulating lipophilic POP burdens during times of negative energy balance. Toxicological investigations of the effect of circulating POP burdens are, however, constrained by logistical challenges associated with large cetacean research, and the limitations of existing non-lethal research approaches.This thesis research was designed to develop a humpback whale derived fibroblast cell culture for species-specific assessment of the toxicological impact of priority POPs and other potential stressors. Thesis (PhD Doctorate) Doctor of Philosophy (PhD) Griffith School of Environemnt Science, Environment, Engineering and Technology Full Text |
author2 |
Susan Bengtson Nash Roger Cropp Deanne Whitworth Kristin Schirmer |
format |
Other/Unknown Material |
author |
Burkard, Michael |
author_facet |
Burkard, Michael |
author_sort |
Burkard, Michael |
title |
Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment |
title_short |
Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment |
title_full |
Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment |
title_fullStr |
Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment |
title_full_unstemmed |
Humpback Whale Cell Lines as an In Vitro Tool for Toxicity Assessment |
title_sort |
humpback whale cell lines as an in vitro tool for toxicity assessment |
publisher |
Griffith University |
publishDate |
2017 |
url |
http://hdl.handle.net/10072/367059 |
long_lat |
ENVELOPE(-155.500,-155.500,-85.883,-85.883) |
geographic |
Antarctic Griffith |
geographic_facet |
Antarctic Griffith |
genre |
Antarc* Antarctic Humpback Whale Megaptera novaeangliae |
genre_facet |
Antarc* Antarctic Humpback Whale Megaptera novaeangliae |
_version_ |
1766193760444612608 |