Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts
Sustainable technologies are vital to reducing the environmental impact of chemical enterprises. Solvents are often seen as just a medium in which a reaction takes place; however they can also play a dominant role in the overall toxicity of a typical pharmaceutical/fine chemicals batch chemical oper...
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Georgia Institute of Technology
2007
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ftgeorgiatech:oai:repository.gatech.edu:1853/16320 2024-06-02T07:58:42+00:00 Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts Hill, Elizabeth M. Eckert, Charles A. Liotta, Charles L. Bommarius, Aneas S. Carson Meredith Lu, Hang Chemical Engineering 2007-07-06 application/pdf http://hdl.handle.net/1853/16320 unknown Georgia Institute of Technology http://hdl.handle.net/1853/16320 Gas-expanded liquids Biphasic separation Biocatalysis Text Dissertation 2007 ftgeorgiatech 2024-05-06T11:44:12Z Sustainable technologies are vital to reducing the environmental impact of chemical enterprises. Solvents are often seen as just a medium in which a reaction takes place; however they can also play a dominant role in the overall toxicity of a typical pharmaceutical/fine chemicals batch chemical operation. Further, careful solvent selection for a reaction may also lead to more facile separation and purification of products, thus reducing the overall cost of a chemical process. This thesis presents an environmentally benign processing technique for sustainable biocatalytic reactions coupled with facile built-in separation. An organic aqueous tunable solvent (OATS) system allows access to a hydrophobic substrate which is transformed with a homogeneous enzymatic catalyst in a single liquid phase. Subsequent CO2 addition produces a biphasic mixture where the hydrophobic product partitions preferentially into the organic rich phase for separation while the hydrophilic enzyme catalyst partitions into the aqueous rich phase, where it is recyclable. Processing parameters in OATS systems are discussed and an overall product recovery of 80% is observed after six reaction cycles. Additionally, greater than 99% enantiomeric excess (ee) is shown for catalyzed hydrolysis of rac-1-phenylethyl acetate with Candida antarctica lipase B (CAL B) both before and after CO2-induced separation. Ph.D. Doctoral or Postdoctoral Thesis Antarc* Antarctica Georgia Institute of Technology: SMARTech - Scholarly Materials and Research at Georgia Tech |
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Georgia Institute of Technology: SMARTech - Scholarly Materials and Research at Georgia Tech |
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unknown |
topic |
Gas-expanded liquids Biphasic separation Biocatalysis |
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Gas-expanded liquids Biphasic separation Biocatalysis Hill, Elizabeth M. Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts |
topic_facet |
Gas-expanded liquids Biphasic separation Biocatalysis |
description |
Sustainable technologies are vital to reducing the environmental impact of chemical enterprises. Solvents are often seen as just a medium in which a reaction takes place; however they can also play a dominant role in the overall toxicity of a typical pharmaceutical/fine chemicals batch chemical operation. Further, careful solvent selection for a reaction may also lead to more facile separation and purification of products, thus reducing the overall cost of a chemical process. This thesis presents an environmentally benign processing technique for sustainable biocatalytic reactions coupled with facile built-in separation. An organic aqueous tunable solvent (OATS) system allows access to a hydrophobic substrate which is transformed with a homogeneous enzymatic catalyst in a single liquid phase. Subsequent CO2 addition produces a biphasic mixture where the hydrophobic product partitions preferentially into the organic rich phase for separation while the hydrophilic enzyme catalyst partitions into the aqueous rich phase, where it is recyclable. Processing parameters in OATS systems are discussed and an overall product recovery of 80% is observed after six reaction cycles. Additionally, greater than 99% enantiomeric excess (ee) is shown for catalyzed hydrolysis of rac-1-phenylethyl acetate with Candida antarctica lipase B (CAL B) both before and after CO2-induced separation. Ph.D. |
author2 |
Eckert, Charles A. Liotta, Charles L. Bommarius, Aneas S. Carson Meredith Lu, Hang Chemical Engineering |
format |
Doctoral or Postdoctoral Thesis |
author |
Hill, Elizabeth M. |
author_facet |
Hill, Elizabeth M. |
author_sort |
Hill, Elizabeth M. |
title |
Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts |
title_short |
Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts |
title_full |
Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts |
title_fullStr |
Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts |
title_full_unstemmed |
Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts |
title_sort |
benign tunable solvents for improved processing of pharmaceutically relevant products and catalysts |
publisher |
Georgia Institute of Technology |
publishDate |
2007 |
url |
http://hdl.handle.net/1853/16320 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
http://hdl.handle.net/1853/16320 |
_version_ |
1800742211829104640 |