Zebra Alphaherpesviruses (EHV-1 and EHV-9)
Alphaherpesviruses are highly prevalent in equine populations and co- infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spon...
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2016
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Online Access: | https://refubium.fu-berlin.de/handle/fub188/20769 https://doi.org/10.17169/refubium-24068 https://doi.org/10.3390/v8090262 |
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ftfuberlin:oai:refubium.fu-berlin.de:fub188/20769 2023-05-15T18:01:46+02:00 Zebra Alphaherpesviruses (EHV-1 and EHV-9) Genetic Diversity, Latency and Co-Infections Abdelgawad, Azza Damiani, Armando Ho, Simon Y. W. Strauss, Guenter Szentiks, Claudia A. East, Marion L. Osterrieder, Nikolaus Greenwood, Alex D. 2016 13 S. application/pdf https://refubium.fu-berlin.de/handle/fub188/20769 https://doi.org/10.17169/refubium-24068 https://doi.org/10.3390/v8090262 eng eng https://refubium.fu-berlin.de/handle/fub188/20769 http://dx.doi.org/10.17169/refubium-24068 doi:10.3390/v8090262 http://creativecommons.org/licenses/by-nc-sa/4.0/ CC-BY-NC-SA EHV-1 EHV-9 zebra latency diversity co-occurrence ddc:630 doc-type:article 2016 ftfuberlin https://doi.org/10.17169/refubium-24068 https://doi.org/10.3390/v8090262 2022-05-15T20:50:21Z Alphaherpesviruses are highly prevalent in equine populations and co- infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spontaneous mutation and recombination. Latency enhances virus survival by providing an epidemiological strategy for long-term maintenance of divergent strains in animal populations. The alphaherpesviruses equine herpesvirus 1 (EHV-1) and 9 (EHV-9) have recently been shown to cross species barriers, including a recombinant EHV-1 observed in fatal infections of a polar bear and Asian rhinoceros. Little is known about the latency and genetic diversity of EHV-1 and EHV-9, especially among zoo and wild equids. Here, we report evidence of limited genetic diversity in EHV-9 in zebras, whereas there is substantial genetic variability in EHV-1. We demonstrate that zebras can be lytically and latently infected with both viruses concurrently. Such a co- occurrence of infection in zebras suggests that even relatively slow-evolving viruses such as equine herpesviruses have the potential to diversify rapidly by recombination. This has potential consequences for the diagnosis of these viruses and their management in wild and captive equid populations. View Full- Text Article in Journal/Newspaper polar bear Freie Universität Berlin: Refubium (FU Berlin) Viruses 8 9 262 |
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Open Polar |
collection |
Freie Universität Berlin: Refubium (FU Berlin) |
op_collection_id |
ftfuberlin |
language |
English |
topic |
EHV-1 EHV-9 zebra latency diversity co-occurrence ddc:630 |
spellingShingle |
EHV-1 EHV-9 zebra latency diversity co-occurrence ddc:630 Abdelgawad, Azza Damiani, Armando Ho, Simon Y. W. Strauss, Guenter Szentiks, Claudia A. East, Marion L. Osterrieder, Nikolaus Greenwood, Alex D. Zebra Alphaherpesviruses (EHV-1 and EHV-9) |
topic_facet |
EHV-1 EHV-9 zebra latency diversity co-occurrence ddc:630 |
description |
Alphaherpesviruses are highly prevalent in equine populations and co- infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be influenced by genetic diversity generated by spontaneous mutation and recombination. Latency enhances virus survival by providing an epidemiological strategy for long-term maintenance of divergent strains in animal populations. The alphaherpesviruses equine herpesvirus 1 (EHV-1) and 9 (EHV-9) have recently been shown to cross species barriers, including a recombinant EHV-1 observed in fatal infections of a polar bear and Asian rhinoceros. Little is known about the latency and genetic diversity of EHV-1 and EHV-9, especially among zoo and wild equids. Here, we report evidence of limited genetic diversity in EHV-9 in zebras, whereas there is substantial genetic variability in EHV-1. We demonstrate that zebras can be lytically and latently infected with both viruses concurrently. Such a co- occurrence of infection in zebras suggests that even relatively slow-evolving viruses such as equine herpesviruses have the potential to diversify rapidly by recombination. This has potential consequences for the diagnosis of these viruses and their management in wild and captive equid populations. View Full- Text |
format |
Article in Journal/Newspaper |
author |
Abdelgawad, Azza Damiani, Armando Ho, Simon Y. W. Strauss, Guenter Szentiks, Claudia A. East, Marion L. Osterrieder, Nikolaus Greenwood, Alex D. |
author_facet |
Abdelgawad, Azza Damiani, Armando Ho, Simon Y. W. Strauss, Guenter Szentiks, Claudia A. East, Marion L. Osterrieder, Nikolaus Greenwood, Alex D. |
author_sort |
Abdelgawad, Azza |
title |
Zebra Alphaherpesviruses (EHV-1 and EHV-9) |
title_short |
Zebra Alphaherpesviruses (EHV-1 and EHV-9) |
title_full |
Zebra Alphaherpesviruses (EHV-1 and EHV-9) |
title_fullStr |
Zebra Alphaherpesviruses (EHV-1 and EHV-9) |
title_full_unstemmed |
Zebra Alphaherpesviruses (EHV-1 and EHV-9) |
title_sort |
zebra alphaherpesviruses (ehv-1 and ehv-9) |
publishDate |
2016 |
url |
https://refubium.fu-berlin.de/handle/fub188/20769 https://doi.org/10.17169/refubium-24068 https://doi.org/10.3390/v8090262 |
genre |
polar bear |
genre_facet |
polar bear |
op_relation |
https://refubium.fu-berlin.de/handle/fub188/20769 http://dx.doi.org/10.17169/refubium-24068 doi:10.3390/v8090262 |
op_rights |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
op_rightsnorm |
CC-BY-NC-SA |
op_doi |
https://doi.org/10.17169/refubium-24068 https://doi.org/10.3390/v8090262 |
container_title |
Viruses |
container_volume |
8 |
container_issue |
9 |
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262 |
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1766171289350832128 |