Table_1_Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.XLSX
Spontaneous canine (Canis lupus) oligodendroglioma (ODG) holds tremendous potential as an immunocompetent large animal model of human malignant gliomas (MG). However, the feasibility of utilizing this model in pre-clinical studies depends on a thorough understanding of the similarities and differenc...
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ftfrontimediafig:oai:figshare.com:article/9609959 2023-05-15T15:51:18+02:00 Table_1_Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.XLSX Dana Mitchell Sreenivasulu Chintala Kaleigh Fetcko Mario Henriquez Brij N. Tewari Atique Ahmed R. Timothy Bentley Mahua Dey 2019-08-14T10:06:11Z https://doi.org/10.3389/fonc.2019.00780.s002 https://figshare.com/articles/Table_1_Common_Molecular_Alterations_in_Canine_Oligodendroglioma_and_Human_Malignant_Gliomas_and_Potential_Novel_Therapeutic_Targets_XLSX/9609959 unknown doi:10.3389/fonc.2019.00780.s002 https://figshare.com/articles/Table_1_Common_Molecular_Alterations_in_Canine_Oligodendroglioma_and_Human_Malignant_Gliomas_and_Potential_Novel_Therapeutic_Targets_XLSX/9609959 CC BY 4.0 CC-BY Cancer Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy Haematological Tumours Molecular Targets Radiation Therapy Solid Tumours Oncology and Carcinogenesis not elsewhere classified canine glioma glioblastoma molecular therapeutic targets malignant glioma anaplastic oligodendroglioma Dataset 2019 ftfrontimediafig https://doi.org/10.3389/fonc.2019.00780.s002 2019-08-14T22:58:55Z Spontaneous canine (Canis lupus) oligodendroglioma (ODG) holds tremendous potential as an immunocompetent large animal model of human malignant gliomas (MG). However, the feasibility of utilizing this model in pre-clinical studies depends on a thorough understanding of the similarities and differences of the molecular pathways associated with gliomas between the two species. We have previously shown that canine ODG has an immune landscape and expression pattern of commonly described oncogenes similar to that of human MG. In the current study, we performed a comprehensive analysis of canine ODG RNAseq data from 4 dogs with ODG and 2 normal controls to identify highly dysregulated genes in canine tumors. We then evaluated the expression of these genes in human MG using Xena Browser, a publicly available database. STRING-database inquiry was used in order to determine the suggested protein associations of these differentially expressed genes as well as the dysregulated pathways commonly enriched by the protein products of these genes in both canine ODG and human MG. Our results revealed that 3,712 (23%) of the 15,895 differentially expressed genes demonstrated significant up- or downregulation (log2-fold change > 2.0). Of the 3,712 altered genes, ~50% were upregulated (n = 1858) and ~50% were downregulated (n = 1854). Most of these genes were also found to have altered expression in human MG. Protein association and pathway analysis revealed common pathways enriched by members of the up- and downregulated gene categories in both species. In summary, we demonstrate that a similar pattern of gene dysregulation characterizes both human MG and canine ODG and provide additional support for the use of the canine model in order to therapeutically target these common genes. The results of such therapeutic targeting in the canine model can serve to more accurately predict the efficacy of anti-glioma therapies in human patients. Dataset Canis lupus Frontiers: Figshare |
institution |
Open Polar |
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Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Cancer Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy Haematological Tumours Molecular Targets Radiation Therapy Solid Tumours Oncology and Carcinogenesis not elsewhere classified canine glioma glioblastoma molecular therapeutic targets malignant glioma anaplastic oligodendroglioma |
spellingShingle |
Cancer Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy Haematological Tumours Molecular Targets Radiation Therapy Solid Tumours Oncology and Carcinogenesis not elsewhere classified canine glioma glioblastoma molecular therapeutic targets malignant glioma anaplastic oligodendroglioma Dana Mitchell Sreenivasulu Chintala Kaleigh Fetcko Mario Henriquez Brij N. Tewari Atique Ahmed R. Timothy Bentley Mahua Dey Table_1_Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.XLSX |
topic_facet |
Cancer Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy Haematological Tumours Molecular Targets Radiation Therapy Solid Tumours Oncology and Carcinogenesis not elsewhere classified canine glioma glioblastoma molecular therapeutic targets malignant glioma anaplastic oligodendroglioma |
description |
Spontaneous canine (Canis lupus) oligodendroglioma (ODG) holds tremendous potential as an immunocompetent large animal model of human malignant gliomas (MG). However, the feasibility of utilizing this model in pre-clinical studies depends on a thorough understanding of the similarities and differences of the molecular pathways associated with gliomas between the two species. We have previously shown that canine ODG has an immune landscape and expression pattern of commonly described oncogenes similar to that of human MG. In the current study, we performed a comprehensive analysis of canine ODG RNAseq data from 4 dogs with ODG and 2 normal controls to identify highly dysregulated genes in canine tumors. We then evaluated the expression of these genes in human MG using Xena Browser, a publicly available database. STRING-database inquiry was used in order to determine the suggested protein associations of these differentially expressed genes as well as the dysregulated pathways commonly enriched by the protein products of these genes in both canine ODG and human MG. Our results revealed that 3,712 (23%) of the 15,895 differentially expressed genes demonstrated significant up- or downregulation (log2-fold change > 2.0). Of the 3,712 altered genes, ~50% were upregulated (n = 1858) and ~50% were downregulated (n = 1854). Most of these genes were also found to have altered expression in human MG. Protein association and pathway analysis revealed common pathways enriched by members of the up- and downregulated gene categories in both species. In summary, we demonstrate that a similar pattern of gene dysregulation characterizes both human MG and canine ODG and provide additional support for the use of the canine model in order to therapeutically target these common genes. The results of such therapeutic targeting in the canine model can serve to more accurately predict the efficacy of anti-glioma therapies in human patients. |
format |
Dataset |
author |
Dana Mitchell Sreenivasulu Chintala Kaleigh Fetcko Mario Henriquez Brij N. Tewari Atique Ahmed R. Timothy Bentley Mahua Dey |
author_facet |
Dana Mitchell Sreenivasulu Chintala Kaleigh Fetcko Mario Henriquez Brij N. Tewari Atique Ahmed R. Timothy Bentley Mahua Dey |
author_sort |
Dana Mitchell |
title |
Table_1_Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.XLSX |
title_short |
Table_1_Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.XLSX |
title_full |
Table_1_Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.XLSX |
title_fullStr |
Table_1_Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.XLSX |
title_full_unstemmed |
Table_1_Common Molecular Alterations in Canine Oligodendroglioma and Human Malignant Gliomas and Potential Novel Therapeutic Targets.XLSX |
title_sort |
table_1_common molecular alterations in canine oligodendroglioma and human malignant gliomas and potential novel therapeutic targets.xlsx |
publishDate |
2019 |
url |
https://doi.org/10.3389/fonc.2019.00780.s002 https://figshare.com/articles/Table_1_Common_Molecular_Alterations_in_Canine_Oligodendroglioma_and_Human_Malignant_Gliomas_and_Potential_Novel_Therapeutic_Targets_XLSX/9609959 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
doi:10.3389/fonc.2019.00780.s002 https://figshare.com/articles/Table_1_Common_Molecular_Alterations_in_Canine_Oligodendroglioma_and_Human_Malignant_Gliomas_and_Potential_Novel_Therapeutic_Targets_XLSX/9609959 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fonc.2019.00780.s002 |
_version_ |
1766386447855648768 |