Image1_Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.PDF
A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples o...
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ftfrontimediafig:oai:figshare.com:article/6169670 2023-05-15T15:15:28+02:00 Image1_Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.PDF Aida Sarmiento-Vizcaíno Julia Espadas Jesús Martín Alfredo F. Braña Fernando Reyes Luis A. García Gloria Blanco 2018-04-23T04:05:11Z https://doi.org/10.3389/fmicb.2018.00773.s001 https://figshare.com/articles/Image1_Atmospheric_Precipitations_Hailstone_and_Rainwater_as_a_Novel_Source_of_Streptomyces_Producing_Bioactive_Natural_Products_PDF/6169670 unknown doi:10.3389/fmicb.2018.00773.s001 https://figshare.com/articles/Image1_Atmospheric_Precipitations_Hailstone_and_Rainwater_as_a_Novel_Source_of_Streptomyces_Producing_Bioactive_Natural_Products_PDF/6169670 CC BY 4.0 CC-BY Microbiology Microbial Genetics Microbial Ecology Mycology hailstorm bioaerosols Streptomyces antibiotic antimicrobial antitumor Image Figure 2018 ftfrontimediafig https://doi.org/10.3389/fmicb.2018.00773.s001 2018-04-25T22:57:18Z A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples of hailstone and rainwater, collected from this hailstorm event, were studied here. Taxonomic identification by 16S rRNA sequencing revealed more than 20 different Streptomyces species, with their closest homologs displaying mainly oceanic but also terrestrial origins. Backward trajectory analysis revealed that the air-mass sources of the hailstorm event, with North Western winds, were originated in the Arctic Ocean (West Greenland and North Iceland) and Canada (Labrador), depending on the altitude. After traveling across the North Atlantic Ocean during 4 days the air mass reached Europe and precipitated as hailstone and rain water at the sampling place in Spain. The finding of Streptomyces species able to survive and disperse through the atmosphere increases our knowledge of the biogeography of genus Streptomyces on Earth, and reinforces our previous dispersion model, suggesting a generalized feature for the genus which could have been essential in his evolution. This unique atmospheric-derived Streptomyces collection was screened for production of bioactive secondary metabolites. Analyses of isolates ethyl acetate extracts by LC-UV-MS and further database comparison revealed an extraordinary diversity of bioactive natural products. One hundred molecules were identified, mostly displaying contrasted antibiotic and antitumor/cytotoxic activities, but also antiparasitic, antiviral, anti-inflammatory, neuroprotector, and insecticide properties. More interestingly, 38 molecules not identified in natural products databases might represent new natural products. Our results revealed for the first time an extraordinary diversity of Streptomyces species in the atmosphere able to produce an extraordinary repertoire of bioactive ... Still Image Arctic Arctic Ocean Greenland Iceland North Atlantic Frontiers: Figshare Arctic Arctic Ocean Canada Greenland |
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Frontiers: Figshare |
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ftfrontimediafig |
language |
unknown |
topic |
Microbiology Microbial Genetics Microbial Ecology Mycology hailstorm bioaerosols Streptomyces antibiotic antimicrobial antitumor |
spellingShingle |
Microbiology Microbial Genetics Microbial Ecology Mycology hailstorm bioaerosols Streptomyces antibiotic antimicrobial antitumor Aida Sarmiento-Vizcaíno Julia Espadas Jesús Martín Alfredo F. Braña Fernando Reyes Luis A. García Gloria Blanco Image1_Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.PDF |
topic_facet |
Microbiology Microbial Genetics Microbial Ecology Mycology hailstorm bioaerosols Streptomyces antibiotic antimicrobial antitumor |
description |
A cultivation-dependent approach revealed that highly diverse populations of Streptomyces were present in atmospheric precipitations from a hailstorm event sampled in February 2016 in the Cantabrian Sea coast, North of Spain. A total of 29 bioactive Streptomyces strains isolated from small samples of hailstone and rainwater, collected from this hailstorm event, were studied here. Taxonomic identification by 16S rRNA sequencing revealed more than 20 different Streptomyces species, with their closest homologs displaying mainly oceanic but also terrestrial origins. Backward trajectory analysis revealed that the air-mass sources of the hailstorm event, with North Western winds, were originated in the Arctic Ocean (West Greenland and North Iceland) and Canada (Labrador), depending on the altitude. After traveling across the North Atlantic Ocean during 4 days the air mass reached Europe and precipitated as hailstone and rain water at the sampling place in Spain. The finding of Streptomyces species able to survive and disperse through the atmosphere increases our knowledge of the biogeography of genus Streptomyces on Earth, and reinforces our previous dispersion model, suggesting a generalized feature for the genus which could have been essential in his evolution. This unique atmospheric-derived Streptomyces collection was screened for production of bioactive secondary metabolites. Analyses of isolates ethyl acetate extracts by LC-UV-MS and further database comparison revealed an extraordinary diversity of bioactive natural products. One hundred molecules were identified, mostly displaying contrasted antibiotic and antitumor/cytotoxic activities, but also antiparasitic, antiviral, anti-inflammatory, neuroprotector, and insecticide properties. More interestingly, 38 molecules not identified in natural products databases might represent new natural products. Our results revealed for the first time an extraordinary diversity of Streptomyces species in the atmosphere able to produce an extraordinary repertoire of bioactive ... |
format |
Still Image |
author |
Aida Sarmiento-Vizcaíno Julia Espadas Jesús Martín Alfredo F. Braña Fernando Reyes Luis A. García Gloria Blanco |
author_facet |
Aida Sarmiento-Vizcaíno Julia Espadas Jesús Martín Alfredo F. Braña Fernando Reyes Luis A. García Gloria Blanco |
author_sort |
Aida Sarmiento-Vizcaíno |
title |
Image1_Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.PDF |
title_short |
Image1_Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.PDF |
title_full |
Image1_Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.PDF |
title_fullStr |
Image1_Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.PDF |
title_full_unstemmed |
Image1_Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.PDF |
title_sort |
image1_atmospheric precipitations, hailstone and rainwater, as a novel source of streptomyces producing bioactive natural products.pdf |
publishDate |
2018 |
url |
https://doi.org/10.3389/fmicb.2018.00773.s001 https://figshare.com/articles/Image1_Atmospheric_Precipitations_Hailstone_and_Rainwater_as_a_Novel_Source_of_Streptomyces_Producing_Bioactive_Natural_Products_PDF/6169670 |
geographic |
Arctic Arctic Ocean Canada Greenland |
geographic_facet |
Arctic Arctic Ocean Canada Greenland |
genre |
Arctic Arctic Ocean Greenland Iceland North Atlantic |
genre_facet |
Arctic Arctic Ocean Greenland Iceland North Atlantic |
op_relation |
doi:10.3389/fmicb.2018.00773.s001 https://figshare.com/articles/Image1_Atmospheric_Precipitations_Hailstone_and_Rainwater_as_a_Novel_Source_of_Streptomyces_Producing_Bioactive_Natural_Products_PDF/6169670 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fmicb.2018.00773.s001 |
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1766345843848249344 |