DataSheet1_Unveiling the functional diversity of ionotropic glutamate receptors in the Pacific oyster (Crassostrea gigas) by systematic studies.pdf
Ionotropic glutamate receptors (iGluRs), pivotal in mediating excitatory neurosignals within the central nervous system, are instrumental in environmental stress responses. In this investigation, 12 iGluRs identified in the Pacific oyster are herein designated as CgiGluRs, and further categorized in...
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ftfrontimediafig:oai:figshare.com:article/24432490 2023-11-12T04:16:10+01:00 DataSheet1_Unveiling the functional diversity of ionotropic glutamate receptors in the Pacific oyster (Crassostrea gigas) by systematic studies.pdf Xueshu Zhang Linfang Zhang Yiran Si Xue Wen Lingling Wang Linsheng Song 2023-10-25T04:15:53Z https://doi.org/10.3389/fphys.2023.1280553.s001 https://figshare.com/articles/dataset/DataSheet1_Unveiling_the_functional_diversity_of_ionotropic_glutamate_receptors_in_the_Pacific_oyster_Crassostrea_gigas_by_systematic_studies_pdf/24432490 unknown doi:10.3389/fphys.2023.1280553.s001 https://figshare.com/articles/dataset/DataSheet1_Unveiling_the_functional_diversity_of_ionotropic_glutamate_receptors_in_the_Pacific_oyster_Crassostrea_gigas_by_systematic_studies_pdf/24432490 CC BY 4.0 Physiology Exercise Physiology Nutritional Physiology Reproduction Cell Physiology Systems Physiology Animal Physiology - Biophysics Animal Physiology - Cell Animal Physiology - Systems Comparative Physiology Physiology not elsewhere classified ionotropic glutamate receptors Crassostrea gigas metal stress environmental sensing physiological adaptation Dataset 2023 ftfrontimediafig https://doi.org/10.3389/fphys.2023.1280553.s001 2023-10-25T23:12:49Z Ionotropic glutamate receptors (iGluRs), pivotal in mediating excitatory neurosignals within the central nervous system, are instrumental in environmental stress responses. In this investigation, 12 iGluRs identified in the Pacific oyster are herein designated as CgiGluRs, and further categorized into three distinct subfamilies based on their transmembrane domains. Cross-species evolutionary analysis unveiled a high degree of conservation in the sequence and structural attributes of these CgiGluRs. These receptors are ubiquitously distributed across various tissues, with pronounced expression in the oyster’s mantle, labial palps, and gills, underlining their integral role in the oyster’s environmental sensing mechanisms. Post the D-shaped larval stage, a marked upward trend in CgiGluRs expression was observed, denoting their critical involvement in oyster development beyond this phase. Exposure to five metals—cadmium (Cd), copper (Cu), zinc (Zn), mercury (Hg), and lead (Pb)—elicited a significant upregulation of CgGRIA4 expression, indicating a robust response to metal stress. A KEGG enrichment analysis on 142 genes, exhibiting parallel expression trends with CgGRIA4 under metal stress, suggests that CgGRIA4 could augment excitatory signal transmission by activating glutamatergic and dopaminergic synapses, thereby contributing to the metal stress response in the oyster. This inquiry not only bolsters our comprehension of the iGluRs gene family in metal stress response but also paves the way for future exploration of its cardinal role in cellular signaling and environmental adaptability. Dataset Crassostrea gigas Pacific oyster Frontiers: Figshare Pacific |
institution |
Open Polar |
collection |
Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Physiology Exercise Physiology Nutritional Physiology Reproduction Cell Physiology Systems Physiology Animal Physiology - Biophysics Animal Physiology - Cell Animal Physiology - Systems Comparative Physiology Physiology not elsewhere classified ionotropic glutamate receptors Crassostrea gigas metal stress environmental sensing physiological adaptation |
spellingShingle |
Physiology Exercise Physiology Nutritional Physiology Reproduction Cell Physiology Systems Physiology Animal Physiology - Biophysics Animal Physiology - Cell Animal Physiology - Systems Comparative Physiology Physiology not elsewhere classified ionotropic glutamate receptors Crassostrea gigas metal stress environmental sensing physiological adaptation Xueshu Zhang Linfang Zhang Yiran Si Xue Wen Lingling Wang Linsheng Song DataSheet1_Unveiling the functional diversity of ionotropic glutamate receptors in the Pacific oyster (Crassostrea gigas) by systematic studies.pdf |
topic_facet |
Physiology Exercise Physiology Nutritional Physiology Reproduction Cell Physiology Systems Physiology Animal Physiology - Biophysics Animal Physiology - Cell Animal Physiology - Systems Comparative Physiology Physiology not elsewhere classified ionotropic glutamate receptors Crassostrea gigas metal stress environmental sensing physiological adaptation |
description |
Ionotropic glutamate receptors (iGluRs), pivotal in mediating excitatory neurosignals within the central nervous system, are instrumental in environmental stress responses. In this investigation, 12 iGluRs identified in the Pacific oyster are herein designated as CgiGluRs, and further categorized into three distinct subfamilies based on their transmembrane domains. Cross-species evolutionary analysis unveiled a high degree of conservation in the sequence and structural attributes of these CgiGluRs. These receptors are ubiquitously distributed across various tissues, with pronounced expression in the oyster’s mantle, labial palps, and gills, underlining their integral role in the oyster’s environmental sensing mechanisms. Post the D-shaped larval stage, a marked upward trend in CgiGluRs expression was observed, denoting their critical involvement in oyster development beyond this phase. Exposure to five metals—cadmium (Cd), copper (Cu), zinc (Zn), mercury (Hg), and lead (Pb)—elicited a significant upregulation of CgGRIA4 expression, indicating a robust response to metal stress. A KEGG enrichment analysis on 142 genes, exhibiting parallel expression trends with CgGRIA4 under metal stress, suggests that CgGRIA4 could augment excitatory signal transmission by activating glutamatergic and dopaminergic synapses, thereby contributing to the metal stress response in the oyster. This inquiry not only bolsters our comprehension of the iGluRs gene family in metal stress response but also paves the way for future exploration of its cardinal role in cellular signaling and environmental adaptability. |
format |
Dataset |
author |
Xueshu Zhang Linfang Zhang Yiran Si Xue Wen Lingling Wang Linsheng Song |
author_facet |
Xueshu Zhang Linfang Zhang Yiran Si Xue Wen Lingling Wang Linsheng Song |
author_sort |
Xueshu Zhang |
title |
DataSheet1_Unveiling the functional diversity of ionotropic glutamate receptors in the Pacific oyster (Crassostrea gigas) by systematic studies.pdf |
title_short |
DataSheet1_Unveiling the functional diversity of ionotropic glutamate receptors in the Pacific oyster (Crassostrea gigas) by systematic studies.pdf |
title_full |
DataSheet1_Unveiling the functional diversity of ionotropic glutamate receptors in the Pacific oyster (Crassostrea gigas) by systematic studies.pdf |
title_fullStr |
DataSheet1_Unveiling the functional diversity of ionotropic glutamate receptors in the Pacific oyster (Crassostrea gigas) by systematic studies.pdf |
title_full_unstemmed |
DataSheet1_Unveiling the functional diversity of ionotropic glutamate receptors in the Pacific oyster (Crassostrea gigas) by systematic studies.pdf |
title_sort |
datasheet1_unveiling the functional diversity of ionotropic glutamate receptors in the pacific oyster (crassostrea gigas) by systematic studies.pdf |
publishDate |
2023 |
url |
https://doi.org/10.3389/fphys.2023.1280553.s001 https://figshare.com/articles/dataset/DataSheet1_Unveiling_the_functional_diversity_of_ionotropic_glutamate_receptors_in_the_Pacific_oyster_Crassostrea_gigas_by_systematic_studies_pdf/24432490 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
doi:10.3389/fphys.2023.1280553.s001 https://figshare.com/articles/dataset/DataSheet1_Unveiling_the_functional_diversity_of_ionotropic_glutamate_receptors_in_the_Pacific_oyster_Crassostrea_gigas_by_systematic_studies_pdf/24432490 |
op_rights |
CC BY 4.0 |
op_doi |
https://doi.org/10.3389/fphys.2023.1280553.s001 |
_version_ |
1782333330511888384 |