Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF
Although obesity in the domestic dog (Canis lupus familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide a...
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ftfrontimediafig:oai:figshare.com:article/24165651 2024-09-15T18:01:22+00:00 Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF Michal Antkowiak Maciej Szydlowski 2023-09-20T04:13:52Z https://doi.org/10.3389/fgene.2023.1235821.s002 https://figshare.com/articles/figure/Image2_Uncovering_structural_variants_associated_with_body_weight_and_obesity_risk_in_labrador_retrievers_a_genome-wide_study_TIF/24165651 unknown doi:10.3389/fgene.2023.1235821.s002 https://figshare.com/articles/figure/Image2_Uncovering_structural_variants_associated_with_body_weight_and_obesity_risk_in_labrador_retrievers_a_genome-wide_study_TIF/24165651 CC BY 4.0 Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy labrador retriever obesity ALPL KCTD8 SGSM1 SLC12A6 RYR3 VPS26C Image Figure 2023 ftfrontimediafig https://doi.org/10.3389/fgene.2023.1235821.s002 2024-08-19T06:20:03Z Although obesity in the domestic dog (Canis lupus familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide analysis to identify structural variants linked to body weight and obesity. Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. Data from whole-gene sequencing of fifty dogs, including 28 obese dogs, were bioinformatically analyzed to identify potential structural variants that varied in frequency between obese and healthy dogs. The seven most promising variants were further analyzed by droplet digital PCR in a group of 110 dogs, including 63 obese. Our statistical evidence suggests that common structural mutations in or near six genes, specifically ALPL, KCTD8, SGSM1, SLC12A6, RYR3, and VPS26C, may contribute to the variability observed in body weight and body condition scores among Labrador Retriever dogs. These findings emphasize the need for additional research to validate the associations and explore the specific functions of these genes in relation to canine obesity. Still Image Canis lupus Frontiers: Figshare |
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Open Polar |
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Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
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unknown |
topic |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy labrador retriever obesity ALPL KCTD8 SGSM1 SLC12A6 RYR3 VPS26C |
spellingShingle |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy labrador retriever obesity ALPL KCTD8 SGSM1 SLC12A6 RYR3 VPS26C Michal Antkowiak Maciej Szydlowski Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF |
topic_facet |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy labrador retriever obesity ALPL KCTD8 SGSM1 SLC12A6 RYR3 VPS26C |
description |
Although obesity in the domestic dog (Canis lupus familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide analysis to identify structural variants linked to body weight and obesity. Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. Data from whole-gene sequencing of fifty dogs, including 28 obese dogs, were bioinformatically analyzed to identify potential structural variants that varied in frequency between obese and healthy dogs. The seven most promising variants were further analyzed by droplet digital PCR in a group of 110 dogs, including 63 obese. Our statistical evidence suggests that common structural mutations in or near six genes, specifically ALPL, KCTD8, SGSM1, SLC12A6, RYR3, and VPS26C, may contribute to the variability observed in body weight and body condition scores among Labrador Retriever dogs. These findings emphasize the need for additional research to validate the associations and explore the specific functions of these genes in relation to canine obesity. |
format |
Still Image |
author |
Michal Antkowiak Maciej Szydlowski |
author_facet |
Michal Antkowiak Maciej Szydlowski |
author_sort |
Michal Antkowiak |
title |
Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF |
title_short |
Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF |
title_full |
Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF |
title_fullStr |
Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF |
title_full_unstemmed |
Image2_Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.TIF |
title_sort |
image2_uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.tif |
publishDate |
2023 |
url |
https://doi.org/10.3389/fgene.2023.1235821.s002 https://figshare.com/articles/figure/Image2_Uncovering_structural_variants_associated_with_body_weight_and_obesity_risk_in_labrador_retrievers_a_genome-wide_study_TIF/24165651 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
doi:10.3389/fgene.2023.1235821.s002 https://figshare.com/articles/figure/Image2_Uncovering_structural_variants_associated_with_body_weight_and_obesity_risk_in_labrador_retrievers_a_genome-wide_study_TIF/24165651 |
op_rights |
CC BY 4.0 |
op_doi |
https://doi.org/10.3389/fgene.2023.1235821.s002 |
_version_ |
1810438527356239872 |