Data_Sheet_1_Brand-specific estimates of influenza vaccine effectiveness for the 2021–2022 season in Europe: results from the DRIVE multi-stakeholder study platform.docx

• Main Authors: Anke L. Stuurman, Antonio Carmona, Jorne Biccler, Alexandre Descamps, Miriam Levi, Ulrike Baum, Ainara Mira-Iglesias, Stefania Bellino, Uy Hoang, Simon de Lusignan, Roberto Bonaiuti, Bruno Lina, Caterina Rizzo, Hanna Nohynek, Javier Díez-Domingo, DRIVE Study Contributors
• Format: Dataset
• Language: unknown
• Published: 2023
• Subjects: Mental Health Nursing; Midwifery; Nursing not elsewhere classified; Aboriginal and Torres Strait Islander Health; Aged Health Care; Care for Disabled; Community Child Health; Environmental and Occupational Health and Safety; Epidemiology; Family Care; Health and Community Services; Health Care Administration; Health Counselling; Health Information Systems (incl. Surveillance); Health Promotion; Preventive Medicine; Primary Health Care; Public Health and Health Services not elsewhere classified; Nanotoxicology; Health and Safety; Medicine; Nursing and Health Curriculum and Pedagogy; vaccine effectiveness; influenza; influenza vaccines; test-negative design; post authorization; real-world evidence; Europe; Iceland
• Online Access: https://doi.org/10.3389/fpubh.2023.1195409.s001; https://figshare.com/articles/dataset/Data_Sheet_1_Brand-specific_estimates_of_influenza_vaccine_effectiveness_for_the_2021_2022_season_in_Europe_results_from_the_DRIVE_multi-stakeholder_study_platform_docx/23715147

Introduction Development of Robust and Innovative Vaccine Effectiveness (DRIVE) was a European public–private partnership (PPP) that aimed to provide annual, brand-specific estimates of influenza vaccine effectiveness (IVE) for regulatory and public health purposes. DRIVE was launched in 2017 under the umbrella of the Innovative Medicines Initiative (IMI) and conducted IVE studies from its pilot season in 2017–2018 to its final season in 2021–2022. Methods In 2021–2022, DRIVE conducted four primary care-based test-negative design (TND) studies (Austria, Italy, Iceland, and England; involving >1,000 general practitioners), nine hospital-based TND studies (France, Iceland, Italy, Romania, and Spain, for a total of 21 hospitals), and one population-based cohort study in Finland. In the TND studies, patients with influenza-like illness (primary care) or severe acute respiratory infection (hospital) were enrolled, and laboratory tested for influenza using RT-PCR. Study contributor-specific IVE was calculated using logistic regression, adjusting for age, sex, and calendar time, and pooled by meta-analysis. Results In 2021–2022, pooled confounder-adjusted influenza vaccine effectiveness (IVE) estimates against laboratory-confirmed influenza (LCI) overall and per type and subtype/lineage was produced, albeit with wide confidence intervals (CI). The limited circulation of influenza in Europe did not allow the network to reach the optimal sample size to produce precise IVE estimates for all the brands included. The most significant IVE estimates were 76% (95% CI 23%−93%) for any vaccine and 81% (22%−95%) for Vaxigrip Tetra in adults ≥65 years old and 64% (25%−83%) for Fluenz Tetra in children (TND primary care setting), 85% (12%−97%) for any vaccine in adults 18–64 years (TND hospital setting), and 38% (1%−62%) in children 6 months−6 years (population-based cohort, mixed setting). Discussion Over five seasons, DRIVE collected data on >35,000 patients, more than 60 variables, and 13 influenza vaccines. DRIVE ...