Table_1_Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx
Background Gliomas account for over two-thirds of all malignant brain tumors and have few established risk factors beyond family history and exposure to ionizing radiation. Importantly, recent studies highlighted the exposure to ultrafine particles (UFP) as a putative risk factor for malignant brain...
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ftfrontimediafig:oai:figshare.com:article/22827266 2024-09-15T18:26:39+00:00 Table_1_Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx Xinyu Ji Akram Alakel Feras M. Ghazawi Matthew Tsang Andrei Zubarev Oliver J. Lasry Ivan V. Litvinov 2023-05-16T04:14:41Z https://doi.org/10.3389/fonc.2023.1190366.s001 https://figshare.com/articles/dataset/Table_1_Investigation_of_incidence_and_geographic_distribution_of_gliomas_in_Canada_from_1992_to_2010_a_national_population-based_study_highlighting_the_importance_of_exposure_to_airport_operations_docx/22827266 unknown doi:10.3389/fonc.2023.1190366.s001 https://figshare.com/articles/dataset/Table_1_Investigation_of_incidence_and_geographic_distribution_of_gliomas_in_Canada_from_1992_to_2010_a_national_population-based_study_highlighting_the_importance_of_exposure_to_airport_operations_docx/22827266 CC BY 4.0 Cancer Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy Haematological Tumours Molecular Targets Radiation Therapy Solid Tumours Oncology and Carcinogenesis not elsewhere classified glioblastoma epidemiology public health airport operations ultrafine particles (UFPs) glioma Dataset 2023 ftfrontimediafig https://doi.org/10.3389/fonc.2023.1190366.s001 2024-08-19T06:19:56Z Background Gliomas account for over two-thirds of all malignant brain tumors and have few established risk factors beyond family history and exposure to ionizing radiation. Importantly, recent studies highlighted the exposure to ultrafine particles (UFP) as a putative risk factor for malignant brain tumors. Methods Clinical and geographic data encompassing all provinces and territories from 1992 to 2010 was obtained from the Canadian Cancer Registry and Le Registre Québécois du Cancer. Linear regression and joinpoint analyses were performed to assess incidence trends. Significantly higher and lower incidence postal codes were then interrogated using Standard Industrial Classification codes to detect significant industrial activity. Results In Canada, between 1992 and 2010, there were ~32,360 cases of glioma. Of these, 17,115 (52.9%) were glioblastoma. The overall crude incidence rates of 5.45 and 2.87 cases per 100,000 individuals per year for gliomas and glioblastomas, respectively, were identified. Our findings further revealed increasing crude incidence of gliomas/glioblastomas over time. A male predominance was observed. Provinces leading in glioma incidence included Quebec, Nova Scotia, and New Brunswick. Significantly lower crude incidence of glioma was found in Nunavut, Northwest Territories, Ontario, and Alberta. A putative regional clustering of gliomas was observed, with higher incidence rates in postal code areas correlating with industrial activity related to airport operations. Conclusion This study describes the geographic distribution of the glioma disease burden and, potentially, identifies industrial activity related to airport operations as potentially being associated with higher incidence of this cancer. Dataset Northwest Territories Nunavut Frontiers: Figshare |
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Frontiers: Figshare |
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ftfrontimediafig |
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topic |
Cancer Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy Haematological Tumours Molecular Targets Radiation Therapy Solid Tumours Oncology and Carcinogenesis not elsewhere classified glioblastoma epidemiology public health airport operations ultrafine particles (UFPs) glioma |
spellingShingle |
Cancer Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy Haematological Tumours Molecular Targets Radiation Therapy Solid Tumours Oncology and Carcinogenesis not elsewhere classified glioblastoma epidemiology public health airport operations ultrafine particles (UFPs) glioma Xinyu Ji Akram Alakel Feras M. Ghazawi Matthew Tsang Andrei Zubarev Oliver J. Lasry Ivan V. Litvinov Table_1_Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx |
topic_facet |
Cancer Cancer Cell Biology Cancer Diagnosis Cancer Genetics Cancer Therapy (excl. Chemotherapy and Radiation Therapy) Chemotherapy Haematological Tumours Molecular Targets Radiation Therapy Solid Tumours Oncology and Carcinogenesis not elsewhere classified glioblastoma epidemiology public health airport operations ultrafine particles (UFPs) glioma |
description |
Background Gliomas account for over two-thirds of all malignant brain tumors and have few established risk factors beyond family history and exposure to ionizing radiation. Importantly, recent studies highlighted the exposure to ultrafine particles (UFP) as a putative risk factor for malignant brain tumors. Methods Clinical and geographic data encompassing all provinces and territories from 1992 to 2010 was obtained from the Canadian Cancer Registry and Le Registre Québécois du Cancer. Linear regression and joinpoint analyses were performed to assess incidence trends. Significantly higher and lower incidence postal codes were then interrogated using Standard Industrial Classification codes to detect significant industrial activity. Results In Canada, between 1992 and 2010, there were ~32,360 cases of glioma. Of these, 17,115 (52.9%) were glioblastoma. The overall crude incidence rates of 5.45 and 2.87 cases per 100,000 individuals per year for gliomas and glioblastomas, respectively, were identified. Our findings further revealed increasing crude incidence of gliomas/glioblastomas over time. A male predominance was observed. Provinces leading in glioma incidence included Quebec, Nova Scotia, and New Brunswick. Significantly lower crude incidence of glioma was found in Nunavut, Northwest Territories, Ontario, and Alberta. A putative regional clustering of gliomas was observed, with higher incidence rates in postal code areas correlating with industrial activity related to airport operations. Conclusion This study describes the geographic distribution of the glioma disease burden and, potentially, identifies industrial activity related to airport operations as potentially being associated with higher incidence of this cancer. |
format |
Dataset |
author |
Xinyu Ji Akram Alakel Feras M. Ghazawi Matthew Tsang Andrei Zubarev Oliver J. Lasry Ivan V. Litvinov |
author_facet |
Xinyu Ji Akram Alakel Feras M. Ghazawi Matthew Tsang Andrei Zubarev Oliver J. Lasry Ivan V. Litvinov |
author_sort |
Xinyu Ji |
title |
Table_1_Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx |
title_short |
Table_1_Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx |
title_full |
Table_1_Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx |
title_fullStr |
Table_1_Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx |
title_full_unstemmed |
Table_1_Investigation of incidence and geographic distribution of gliomas in Canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx |
title_sort |
table_1_investigation of incidence and geographic distribution of gliomas in canada from 1992 to 2010: a national population-based study highlighting the importance of exposure to airport operations.docx |
publishDate |
2023 |
url |
https://doi.org/10.3389/fonc.2023.1190366.s001 https://figshare.com/articles/dataset/Table_1_Investigation_of_incidence_and_geographic_distribution_of_gliomas_in_Canada_from_1992_to_2010_a_national_population-based_study_highlighting_the_importance_of_exposure_to_airport_operations_docx/22827266 |
genre |
Northwest Territories Nunavut |
genre_facet |
Northwest Territories Nunavut |
op_relation |
doi:10.3389/fonc.2023.1190366.s001 https://figshare.com/articles/dataset/Table_1_Investigation_of_incidence_and_geographic_distribution_of_gliomas_in_Canada_from_1992_to_2010_a_national_population-based_study_highlighting_the_importance_of_exposure_to_airport_operations_docx/22827266 |
op_rights |
CC BY 4.0 |
op_doi |
https://doi.org/10.3389/fonc.2023.1190366.s001 |
_version_ |
1810467168798638080 |