DataSheet2_Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin.DOCX
Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precip...
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Online Access: | https://doi.org/10.3389/fchem.2022.948795.s002 https://figshare.com/articles/dataset/DataSheet2_Natural_products_including_a_new_caboxamycin_from_Streptomyces_and_other_Actinobacteria_isolated_in_Spain_from_storm_clouds_transported_by_Northern_winds_of_Arctic_origin_DOCX/21484161 |
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ftfrontimediafig:oai:figshare.com:article/21484161 2023-05-15T15:04:55+02:00 DataSheet2_Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin.DOCX Aida Sarmiento-Vizcaíno Jesús Martín Francisco Javier Ortiz-López Fernando Reyes Luis A. García Gloria Blanco 2022-11-03T05:14:32Z https://doi.org/10.3389/fchem.2022.948795.s002 https://figshare.com/articles/dataset/DataSheet2_Natural_products_including_a_new_caboxamycin_from_Streptomyces_and_other_Actinobacteria_isolated_in_Spain_from_storm_clouds_transported_by_Northern_winds_of_Arctic_origin_DOCX/21484161 unknown doi:10.3389/fchem.2022.948795.s002 https://figshare.com/articles/dataset/DataSheet2_Natural_products_including_a_new_caboxamycin_from_Streptomyces_and_other_Actinobacteria_isolated_in_Spain_from_storm_clouds_transported_by_Northern_winds_of_Arctic_origin_DOCX/21484161 CC BY 4.0 CC-BY Biochemistry Environmental Chemistry Geochemistry Organic Chemistry Inorganic Chemistry Nuclear Chemistry Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) Medical Biochemistry and Metabolomics not elsewhere classified Food Chemistry and Molecular Gastronomy (excl. Wine) Analytical Biochemistry Cell Neurochemistry Enzymes Electroanalytical Chemistry Analytical Chemistry not elsewhere classified Organic Green Chemistry Physical Organic Chemistry Catalysis and Mechanisms of Reactions Environmental Chemistry (incl. Atmospheric Chemistry) caboxamycin B antibiotic antitumor streptomyces micromonospora nocardiopsis actinomycete Dataset 2022 ftfrontimediafig https://doi.org/10.3389/fchem.2022.948795.s002 2022-11-10T00:11:17Z Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precipitations. Clouds are considered as atmospheric oases for microorganisms and there is a recent paradigm shift whereby atmospheric-derived Actinobacteria emerge as an alternative source for drug discovery. In this context, we studied a total of 18 bioactive Actinobacteria strains, isolated by sampling nine precipitation events with prevailing Northern winds in the Cantabrian Sea coast, Northern Spain. Backward trajectories meteorological analyses indicate that air masses were originated mostly in the Arctic Ocean, and their trajectory to downwind areas involved the Atlantic Ocean and also terrestrial sources from continental Europe, and in some events from Canada, Greenland, Mauritania and Canary Islands. Taxonomic identification of the isolates, by 16S rRNA gene sequencing and phylogenetic analyses, revealed that they are members of three Actinobacteria genera. Fifteen of the isolates are Streptomyces species, thus increasing the number of bioactive species of this genus in the atmosphere to a 6.8% of the total currently validated species. In addition, two of the strains belong to the genus Micromonospora and one to genus Nocardiopsis. These findings reinforce a previous atmospheric dispersal model, extended herein to the genus Micromonospora. Production of bioactive secondary metabolites was screened in ethyl acetate extracts of the strains by LC-UV-MS and a total of 94 secondary metabolites were detected after LC/MS dereplication. Comparative analyses with natural products databases allowed the identification of 69 structurally diverse natural products with contrasted biological activities, mostly as antibiotics and antitumor agents, but also anti-inflammatory, antiviral, antiparasitic, immunosuppressant and ... Dataset Arctic Arctic Ocean Greenland Frontiers: Figshare Arctic Arctic Ocean Canada Greenland |
institution |
Open Polar |
collection |
Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Biochemistry Environmental Chemistry Geochemistry Organic Chemistry Inorganic Chemistry Nuclear Chemistry Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) Medical Biochemistry and Metabolomics not elsewhere classified Food Chemistry and Molecular Gastronomy (excl. Wine) Analytical Biochemistry Cell Neurochemistry Enzymes Electroanalytical Chemistry Analytical Chemistry not elsewhere classified Organic Green Chemistry Physical Organic Chemistry Catalysis and Mechanisms of Reactions Environmental Chemistry (incl. Atmospheric Chemistry) caboxamycin B antibiotic antitumor streptomyces micromonospora nocardiopsis actinomycete |
spellingShingle |
Biochemistry Environmental Chemistry Geochemistry Organic Chemistry Inorganic Chemistry Nuclear Chemistry Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) Medical Biochemistry and Metabolomics not elsewhere classified Food Chemistry and Molecular Gastronomy (excl. Wine) Analytical Biochemistry Cell Neurochemistry Enzymes Electroanalytical Chemistry Analytical Chemistry not elsewhere classified Organic Green Chemistry Physical Organic Chemistry Catalysis and Mechanisms of Reactions Environmental Chemistry (incl. Atmospheric Chemistry) caboxamycin B antibiotic antitumor streptomyces micromonospora nocardiopsis actinomycete Aida Sarmiento-Vizcaíno Jesús Martín Francisco Javier Ortiz-López Fernando Reyes Luis A. García Gloria Blanco DataSheet2_Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin.DOCX |
topic_facet |
Biochemistry Environmental Chemistry Geochemistry Organic Chemistry Inorganic Chemistry Nuclear Chemistry Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) Medical Biochemistry and Metabolomics not elsewhere classified Food Chemistry and Molecular Gastronomy (excl. Wine) Analytical Biochemistry Cell Neurochemistry Enzymes Electroanalytical Chemistry Analytical Chemistry not elsewhere classified Organic Green Chemistry Physical Organic Chemistry Catalysis and Mechanisms of Reactions Environmental Chemistry (incl. Atmospheric Chemistry) caboxamycin B antibiotic antitumor streptomyces micromonospora nocardiopsis actinomycete |
description |
Actinobacteria, mostly Streptomyces species, are the main source of natural products essential in medicine. While the majority of producer microorganisms of secondary metabolite are reported from terrestrial or marine environments, there are limited reports of their isolation from atmospheric precipitations. Clouds are considered as atmospheric oases for microorganisms and there is a recent paradigm shift whereby atmospheric-derived Actinobacteria emerge as an alternative source for drug discovery. In this context, we studied a total of 18 bioactive Actinobacteria strains, isolated by sampling nine precipitation events with prevailing Northern winds in the Cantabrian Sea coast, Northern Spain. Backward trajectories meteorological analyses indicate that air masses were originated mostly in the Arctic Ocean, and their trajectory to downwind areas involved the Atlantic Ocean and also terrestrial sources from continental Europe, and in some events from Canada, Greenland, Mauritania and Canary Islands. Taxonomic identification of the isolates, by 16S rRNA gene sequencing and phylogenetic analyses, revealed that they are members of three Actinobacteria genera. Fifteen of the isolates are Streptomyces species, thus increasing the number of bioactive species of this genus in the atmosphere to a 6.8% of the total currently validated species. In addition, two of the strains belong to the genus Micromonospora and one to genus Nocardiopsis. These findings reinforce a previous atmospheric dispersal model, extended herein to the genus Micromonospora. Production of bioactive secondary metabolites was screened in ethyl acetate extracts of the strains by LC-UV-MS and a total of 94 secondary metabolites were detected after LC/MS dereplication. Comparative analyses with natural products databases allowed the identification of 69 structurally diverse natural products with contrasted biological activities, mostly as antibiotics and antitumor agents, but also anti-inflammatory, antiviral, antiparasitic, immunosuppressant and ... |
format |
Dataset |
author |
Aida Sarmiento-Vizcaíno Jesús Martín Francisco Javier Ortiz-López Fernando Reyes Luis A. García Gloria Blanco |
author_facet |
Aida Sarmiento-Vizcaíno Jesús Martín Francisco Javier Ortiz-López Fernando Reyes Luis A. García Gloria Blanco |
author_sort |
Aida Sarmiento-Vizcaíno |
title |
DataSheet2_Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin.DOCX |
title_short |
DataSheet2_Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin.DOCX |
title_full |
DataSheet2_Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin.DOCX |
title_fullStr |
DataSheet2_Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin.DOCX |
title_full_unstemmed |
DataSheet2_Natural products, including a new caboxamycin, from Streptomyces and other Actinobacteria isolated in Spain from storm clouds transported by Northern winds of Arctic origin.DOCX |
title_sort |
datasheet2_natural products, including a new caboxamycin, from streptomyces and other actinobacteria isolated in spain from storm clouds transported by northern winds of arctic origin.docx |
publishDate |
2022 |
url |
https://doi.org/10.3389/fchem.2022.948795.s002 https://figshare.com/articles/dataset/DataSheet2_Natural_products_including_a_new_caboxamycin_from_Streptomyces_and_other_Actinobacteria_isolated_in_Spain_from_storm_clouds_transported_by_Northern_winds_of_Arctic_origin_DOCX/21484161 |
geographic |
Arctic Arctic Ocean Canada Greenland |
geographic_facet |
Arctic Arctic Ocean Canada Greenland |
genre |
Arctic Arctic Ocean Greenland |
genre_facet |
Arctic Arctic Ocean Greenland |
op_relation |
doi:10.3389/fchem.2022.948795.s002 https://figshare.com/articles/dataset/DataSheet2_Natural_products_including_a_new_caboxamycin_from_Streptomyces_and_other_Actinobacteria_isolated_in_Spain_from_storm_clouds_transported_by_Northern_winds_of_Arctic_origin_DOCX/21484161 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fchem.2022.948795.s002 |
_version_ |
1766336666700611584 |