Image6_Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers.JPEG
Currently available genetic tools effectively distinguish between different continental origins. However, North Eurasia, which constitutes one-third of the world’s largest continent, remains severely underrepresented. The dataset used in this study represents 266 populations from 12 North Eurasian c...
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Online Access: | https://doi.org/10.3389/fgene.2022.902309.s006 https://figshare.com/articles/figure/Image6_Determining_the_Area_of_Ancestral_Origin_for_Individuals_From_North_Eurasia_Based_on_5_229_SNP_Markers_JPEG/19770220 |
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ftfrontimediafig:oai:figshare.com:article/19770220 2023-05-15T16:59:29+02:00 Image6_Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers.JPEG Igor Gorin Oleg Balanovsky Oleg Kozlov Sergey Koshel Elena Kostryukova Maxat Zhabagin Anastasiya Agdzhoyan Vladimir Pylev Elena Balanovska 2022-05-16T04:46:37Z https://doi.org/10.3389/fgene.2022.902309.s006 https://figshare.com/articles/figure/Image6_Determining_the_Area_of_Ancestral_Origin_for_Individuals_From_North_Eurasia_Based_on_5_229_SNP_Markers_JPEG/19770220 unknown doi:10.3389/fgene.2022.902309.s006 https://figshare.com/articles/figure/Image6_Determining_the_Area_of_Ancestral_Origin_for_Individuals_From_North_Eurasia_Based_on_5_229_SNP_Markers_JPEG/19770220 CC BY 4.0 CC-BY Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy gene geography ancestry prediction human population genetics ancestral origin machine learning Image Figure 2022 ftfrontimediafig https://doi.org/10.3389/fgene.2022.902309.s006 2022-05-18T23:10:38Z Currently available genetic tools effectively distinguish between different continental origins. However, North Eurasia, which constitutes one-third of the world’s largest continent, remains severely underrepresented. The dataset used in this study represents 266 populations from 12 North Eurasian countries, including most of the ethnic diversity across Russia’s vast territory. A total of 1,883 samples were genotyped using the Illumina Infinium Omni5Exome-4 v1.3 BeadChip. Three principal components were computed for the entire dataset using three iterations for outlier removal. It allowed the merging of 266 populations into larger groups while maintaining intragroup homogeneity, so 29 ethnic geographic groups were formed that were genetically distinguishable enough to trace individual ancestry. Several feature selection methods, including the random forest algorithm, were tested to estimate the number of genetic markers needed to differentiate between the groups; 5,229 ancestry-informative SNPs were selected. We tested various classifiers supporting multiple classes and output values for each class that could be interpreted as probabilities. The logistic regression was chosen as the best mathematical model for predicting ancestral populations. The machine learning algorithm for inferring an ancestral ethnic geographic group was implemented in the original software “Homeland” fitted with the interface module, the prediction module, and the cartographic module. Examples of geographic maps showing the likelihood of geographic ancestry for individuals from different regions of North Eurasia are provided. Validating methods show that the highest number of ethnic geographic group predictions with almost absolute accuracy and sensitivity was observed for South and Central Siberia, Far East, and Kamchatka. The total accuracy of prediction of one of 29 ethnic geographic groups reached 71%. The proposed method can be employed to predict ancestries from the populations of Russia and its neighbor states. It can be used for ... Still Image Kamchatka Siberia Frontiers: Figshare |
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Open Polar |
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Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy gene geography ancestry prediction human population genetics ancestral origin machine learning |
spellingShingle |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy gene geography ancestry prediction human population genetics ancestral origin machine learning Igor Gorin Oleg Balanovsky Oleg Kozlov Sergey Koshel Elena Kostryukova Maxat Zhabagin Anastasiya Agdzhoyan Vladimir Pylev Elena Balanovska Image6_Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers.JPEG |
topic_facet |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy gene geography ancestry prediction human population genetics ancestral origin machine learning |
description |
Currently available genetic tools effectively distinguish between different continental origins. However, North Eurasia, which constitutes one-third of the world’s largest continent, remains severely underrepresented. The dataset used in this study represents 266 populations from 12 North Eurasian countries, including most of the ethnic diversity across Russia’s vast territory. A total of 1,883 samples were genotyped using the Illumina Infinium Omni5Exome-4 v1.3 BeadChip. Three principal components were computed for the entire dataset using three iterations for outlier removal. It allowed the merging of 266 populations into larger groups while maintaining intragroup homogeneity, so 29 ethnic geographic groups were formed that were genetically distinguishable enough to trace individual ancestry. Several feature selection methods, including the random forest algorithm, were tested to estimate the number of genetic markers needed to differentiate between the groups; 5,229 ancestry-informative SNPs were selected. We tested various classifiers supporting multiple classes and output values for each class that could be interpreted as probabilities. The logistic regression was chosen as the best mathematical model for predicting ancestral populations. The machine learning algorithm for inferring an ancestral ethnic geographic group was implemented in the original software “Homeland” fitted with the interface module, the prediction module, and the cartographic module. Examples of geographic maps showing the likelihood of geographic ancestry for individuals from different regions of North Eurasia are provided. Validating methods show that the highest number of ethnic geographic group predictions with almost absolute accuracy and sensitivity was observed for South and Central Siberia, Far East, and Kamchatka. The total accuracy of prediction of one of 29 ethnic geographic groups reached 71%. The proposed method can be employed to predict ancestries from the populations of Russia and its neighbor states. It can be used for ... |
format |
Still Image |
author |
Igor Gorin Oleg Balanovsky Oleg Kozlov Sergey Koshel Elena Kostryukova Maxat Zhabagin Anastasiya Agdzhoyan Vladimir Pylev Elena Balanovska |
author_facet |
Igor Gorin Oleg Balanovsky Oleg Kozlov Sergey Koshel Elena Kostryukova Maxat Zhabagin Anastasiya Agdzhoyan Vladimir Pylev Elena Balanovska |
author_sort |
Igor Gorin |
title |
Image6_Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers.JPEG |
title_short |
Image6_Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers.JPEG |
title_full |
Image6_Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers.JPEG |
title_fullStr |
Image6_Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers.JPEG |
title_full_unstemmed |
Image6_Determining the Area of Ancestral Origin for Individuals From North Eurasia Based on 5,229 SNP Markers.JPEG |
title_sort |
image6_determining the area of ancestral origin for individuals from north eurasia based on 5,229 snp markers.jpeg |
publishDate |
2022 |
url |
https://doi.org/10.3389/fgene.2022.902309.s006 https://figshare.com/articles/figure/Image6_Determining_the_Area_of_Ancestral_Origin_for_Individuals_From_North_Eurasia_Based_on_5_229_SNP_Markers_JPEG/19770220 |
genre |
Kamchatka Siberia |
genre_facet |
Kamchatka Siberia |
op_relation |
doi:10.3389/fgene.2022.902309.s006 https://figshare.com/articles/figure/Image6_Determining_the_Area_of_Ancestral_Origin_for_Individuals_From_North_Eurasia_Based_on_5_229_SNP_Markers_JPEG/19770220 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fgene.2022.902309.s006 |
_version_ |
1766051759307882496 |