DataSheet_1_Toll-Like Receptor Evolution: Does Temperature Matter?.docx
Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs). The isolation of the Antarctic continent and its unique teleost fish and microbiota prompted the present investigation in...
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ftfrontimediafig:oai:figshare.com:article/19167356 2023-05-15T14:02:45+02:00 DataSheet_1_Toll-Like Receptor Evolution: Does Temperature Matter?.docx Cármen Sousa Stefan A. Fernandes João C. R. Cardoso Ying Wang Wanying Zhai Pedro M. Guerreiro Liangbiao Chen Adelino V. M. Canário Deborah M. Power 2022-02-14T04:32:34Z https://doi.org/10.3389/fimmu.2022.812890.s001 https://figshare.com/articles/dataset/DataSheet_1_Toll-Like_Receptor_Evolution_Does_Temperature_Matter_docx/19167356 unknown doi:10.3389/fimmu.2022.812890.s001 https://figshare.com/articles/dataset/DataSheet_1_Toll-Like_Receptor_Evolution_Does_Temperature_Matter_docx/19167356 CC BY 4.0 CC-BY Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology TLR Antarctic fish immune challenge cold temperature evolution Dataset 2022 ftfrontimediafig https://doi.org/10.3389/fimmu.2022.812890.s001 2022-02-17T00:04:57Z Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs). The isolation of the Antarctic continent and its unique teleost fish and microbiota prompted the present investigation into Tlr evolution. Gene homologues of tlr members in teleosts from temperate regions were present in the genome of Antarctic Nototheniidae and the non-Antarctic sister lineage Bovichtidae. Overall, in Nototheniidae apart from D. mawsoni, no major tlr gene family expansion or contraction occurred. Instead, lineage and species-specific changes in the ectodomain and LRR of Tlrs occurred, particularly in the Tlr11 superfamily that is well represented in fish. Positive selective pressure and associated sequence modifications in the TLR ectodomain and within the leucine-rich repeats (LRR), important for pathogen recognition, occurred in Tlr5, Tlr8, Tlr13, Tlr21, Tlr22, and Tlr23 presumably associated with the unique Antarctic microbiota. Exposure to lipopolysaccharide (Escherichia coli O111:B4) Gram negative bacteria did not modify tlr gene expression in N. rossii head–kidney or anterior intestine, although increased water temperature (+4°C) had a significant effect. Dataset Antarc* Antarctic Frontiers: Figshare Antarctic The Antarctic |
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Open Polar |
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Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology TLR Antarctic fish immune challenge cold temperature evolution |
spellingShingle |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology TLR Antarctic fish immune challenge cold temperature evolution Cármen Sousa Stefan A. Fernandes João C. R. Cardoso Ying Wang Wanying Zhai Pedro M. Guerreiro Liangbiao Chen Adelino V. M. Canário Deborah M. Power DataSheet_1_Toll-Like Receptor Evolution: Does Temperature Matter?.docx |
topic_facet |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology TLR Antarctic fish immune challenge cold temperature evolution |
description |
Toll-like receptors (TLRs) recognize conserved pathogen-associated molecular patterns (PAMPs) and are an ancient and well-conserved group of pattern recognition receptors (PRRs). The isolation of the Antarctic continent and its unique teleost fish and microbiota prompted the present investigation into Tlr evolution. Gene homologues of tlr members in teleosts from temperate regions were present in the genome of Antarctic Nototheniidae and the non-Antarctic sister lineage Bovichtidae. Overall, in Nototheniidae apart from D. mawsoni, no major tlr gene family expansion or contraction occurred. Instead, lineage and species-specific changes in the ectodomain and LRR of Tlrs occurred, particularly in the Tlr11 superfamily that is well represented in fish. Positive selective pressure and associated sequence modifications in the TLR ectodomain and within the leucine-rich repeats (LRR), important for pathogen recognition, occurred in Tlr5, Tlr8, Tlr13, Tlr21, Tlr22, and Tlr23 presumably associated with the unique Antarctic microbiota. Exposure to lipopolysaccharide (Escherichia coli O111:B4) Gram negative bacteria did not modify tlr gene expression in N. rossii head–kidney or anterior intestine, although increased water temperature (+4°C) had a significant effect. |
format |
Dataset |
author |
Cármen Sousa Stefan A. Fernandes João C. R. Cardoso Ying Wang Wanying Zhai Pedro M. Guerreiro Liangbiao Chen Adelino V. M. Canário Deborah M. Power |
author_facet |
Cármen Sousa Stefan A. Fernandes João C. R. Cardoso Ying Wang Wanying Zhai Pedro M. Guerreiro Liangbiao Chen Adelino V. M. Canário Deborah M. Power |
author_sort |
Cármen Sousa |
title |
DataSheet_1_Toll-Like Receptor Evolution: Does Temperature Matter?.docx |
title_short |
DataSheet_1_Toll-Like Receptor Evolution: Does Temperature Matter?.docx |
title_full |
DataSheet_1_Toll-Like Receptor Evolution: Does Temperature Matter?.docx |
title_fullStr |
DataSheet_1_Toll-Like Receptor Evolution: Does Temperature Matter?.docx |
title_full_unstemmed |
DataSheet_1_Toll-Like Receptor Evolution: Does Temperature Matter?.docx |
title_sort |
datasheet_1_toll-like receptor evolution: does temperature matter?.docx |
publishDate |
2022 |
url |
https://doi.org/10.3389/fimmu.2022.812890.s001 https://figshare.com/articles/dataset/DataSheet_1_Toll-Like_Receptor_Evolution_Does_Temperature_Matter_docx/19167356 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
doi:10.3389/fimmu.2022.812890.s001 https://figshare.com/articles/dataset/DataSheet_1_Toll-Like_Receptor_Evolution_Does_Temperature_Matter_docx/19167356 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fimmu.2022.812890.s001 |
_version_ |
1766273160089436160 |