Table1_Identification of a New Infectious Pancreatic Necrosis Virus (IPNV) Variant in Atlantic Salmon (Salmo salar L.) that can Cause High Mortality Even in Genetically Resistant Fish.pdf
Infectious pancreatic necrosis (IPN) is an important viral disease of salmonids that can affect fish during various life cycles. In Atlantic salmon, selecting for genetically resistant fish against IPN has been one of the most highly praised success stories in the history of fish breeding. During th...
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ftfrontimediafig:oai:figshare.com:article/17086235 2023-05-15T15:31:05+02:00 Table1_Identification of a New Infectious Pancreatic Necrosis Virus (IPNV) Variant in Atlantic Salmon (Salmo salar L.) that can Cause High Mortality Even in Genetically Resistant Fish.pdf Borghild Hillestad Stein Johannessen Geir Olav Melingen Hooman K. Moghadam 2021-11-26T13:08:12Z https://doi.org/10.3389/fgene.2021.635185.s006 https://figshare.com/articles/dataset/Table1_Identification_of_a_New_Infectious_Pancreatic_Necrosis_Virus_IPNV_Variant_in_Atlantic_Salmon_Salmo_salar_L_that_can_Cause_High_Mortality_Even_in_Genetically_Resistant_Fish_pdf/17086235 unknown doi:10.3389/fgene.2021.635185.s006 https://figshare.com/articles/dataset/Table1_Identification_of_a_New_Infectious_Pancreatic_Necrosis_Virus_IPNV_Variant_in_Atlantic_Salmon_Salmo_salar_L_that_can_Cause_High_Mortality_Even_in_Genetically_Resistant_Fish_pdf/17086235 CC BY 4.0 CC-BY Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy RNA sequencing genome assembly quantitative trait locus (QTL) Atlantic salmon infectious pancreatic necrosis virus (IPNV) Dataset 2021 ftfrontimediafig https://doi.org/10.3389/fgene.2021.635185.s006 2021-12-02T00:02:24Z Infectious pancreatic necrosis (IPN) is an important viral disease of salmonids that can affect fish during various life cycles. In Atlantic salmon, selecting for genetically resistant fish against IPN has been one of the most highly praised success stories in the history of fish breeding. During the late 2000s, the findings that resistance against this disease has a significant genetic component, which is mainly controlled by variations in a single gene, have helped to reduce the IPN outbreaks to a great extent. In this paper, we present the identification of a new variant of the IPN virus from a field outbreak in Western Norway that had caused mortality, even in genetically resistant salmon. We recovered and assembled the full-length genome of this virus, following the deep-sequencing of the head-kidney transcriptome. The comparative sequence analysis revealed that for the critical amino acid motifs, previously found to be associated with the degree of virulence, the newly identified variant is similar to the virus’s avirulent form. However, we detected a set of deduced amino acid residues, particularly in the hypervariable domain of the VP2, that collectively are unique to this variant compared to all other reference sequences assessed in this study. We suggest that these mutations have likely equipped the virus with the capacity to escape the host defence mechanism more efficiently, even in the genetically deemed IPN resistant fish. Dataset Atlantic salmon Salmo salar Frontiers: Figshare Norway |
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Frontiers: Figshare |
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ftfrontimediafig |
language |
unknown |
topic |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy RNA sequencing genome assembly quantitative trait locus (QTL) Atlantic salmon infectious pancreatic necrosis virus (IPNV) |
spellingShingle |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy RNA sequencing genome assembly quantitative trait locus (QTL) Atlantic salmon infectious pancreatic necrosis virus (IPNV) Borghild Hillestad Stein Johannessen Geir Olav Melingen Hooman K. Moghadam Table1_Identification of a New Infectious Pancreatic Necrosis Virus (IPNV) Variant in Atlantic Salmon (Salmo salar L.) that can Cause High Mortality Even in Genetically Resistant Fish.pdf |
topic_facet |
Genetics Genetic Engineering Biomarkers Developmental Genetics (incl. Sex Determination) Epigenetics (incl. Genome Methylation and Epigenomics) Gene Expression (incl. Microarray and other genome-wide approaches) Genome Structure and Regulation Genomics Genetically Modified Animals Livestock Cloning Gene and Molecular Therapy RNA sequencing genome assembly quantitative trait locus (QTL) Atlantic salmon infectious pancreatic necrosis virus (IPNV) |
description |
Infectious pancreatic necrosis (IPN) is an important viral disease of salmonids that can affect fish during various life cycles. In Atlantic salmon, selecting for genetically resistant fish against IPN has been one of the most highly praised success stories in the history of fish breeding. During the late 2000s, the findings that resistance against this disease has a significant genetic component, which is mainly controlled by variations in a single gene, have helped to reduce the IPN outbreaks to a great extent. In this paper, we present the identification of a new variant of the IPN virus from a field outbreak in Western Norway that had caused mortality, even in genetically resistant salmon. We recovered and assembled the full-length genome of this virus, following the deep-sequencing of the head-kidney transcriptome. The comparative sequence analysis revealed that for the critical amino acid motifs, previously found to be associated with the degree of virulence, the newly identified variant is similar to the virus’s avirulent form. However, we detected a set of deduced amino acid residues, particularly in the hypervariable domain of the VP2, that collectively are unique to this variant compared to all other reference sequences assessed in this study. We suggest that these mutations have likely equipped the virus with the capacity to escape the host defence mechanism more efficiently, even in the genetically deemed IPN resistant fish. |
format |
Dataset |
author |
Borghild Hillestad Stein Johannessen Geir Olav Melingen Hooman K. Moghadam |
author_facet |
Borghild Hillestad Stein Johannessen Geir Olav Melingen Hooman K. Moghadam |
author_sort |
Borghild Hillestad |
title |
Table1_Identification of a New Infectious Pancreatic Necrosis Virus (IPNV) Variant in Atlantic Salmon (Salmo salar L.) that can Cause High Mortality Even in Genetically Resistant Fish.pdf |
title_short |
Table1_Identification of a New Infectious Pancreatic Necrosis Virus (IPNV) Variant in Atlantic Salmon (Salmo salar L.) that can Cause High Mortality Even in Genetically Resistant Fish.pdf |
title_full |
Table1_Identification of a New Infectious Pancreatic Necrosis Virus (IPNV) Variant in Atlantic Salmon (Salmo salar L.) that can Cause High Mortality Even in Genetically Resistant Fish.pdf |
title_fullStr |
Table1_Identification of a New Infectious Pancreatic Necrosis Virus (IPNV) Variant in Atlantic Salmon (Salmo salar L.) that can Cause High Mortality Even in Genetically Resistant Fish.pdf |
title_full_unstemmed |
Table1_Identification of a New Infectious Pancreatic Necrosis Virus (IPNV) Variant in Atlantic Salmon (Salmo salar L.) that can Cause High Mortality Even in Genetically Resistant Fish.pdf |
title_sort |
table1_identification of a new infectious pancreatic necrosis virus (ipnv) variant in atlantic salmon (salmo salar l.) that can cause high mortality even in genetically resistant fish.pdf |
publishDate |
2021 |
url |
https://doi.org/10.3389/fgene.2021.635185.s006 https://figshare.com/articles/dataset/Table1_Identification_of_a_New_Infectious_Pancreatic_Necrosis_Virus_IPNV_Variant_in_Atlantic_Salmon_Salmo_salar_L_that_can_Cause_High_Mortality_Even_in_Genetically_Resistant_Fish_pdf/17086235 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
doi:10.3389/fgene.2021.635185.s006 https://figshare.com/articles/dataset/Table1_Identification_of_a_New_Infectious_Pancreatic_Necrosis_Virus_IPNV_Variant_in_Atlantic_Salmon_Salmo_salar_L_that_can_Cause_High_Mortality_Even_in_Genetically_Resistant_Fish_pdf/17086235 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fgene.2021.635185.s006 |
_version_ |
1766361576212791296 |