Data_Sheet_1_Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.PDF
The fungal strains Pseudogymnoascus are a kind of psychrophilic pathogenic fungi that are ubiquitously distributed in Antarctica, while the studies of their secondary metabolites are infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11 led to the isolation o...
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ftfrontimediafig:oai:figshare.com:article/14768286 2023-05-15T13:36:47+02:00 Data_Sheet_1_Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.PDF Ting Shi Xiang-Qian Li Li Zheng Ya-Hui Zhang Jia-Jia Dai Er-Lei Shang Yan-Yan Yu Yi-Ting Zhang Wen-Peng Hu Da-Yong Shi 2021-06-11T05:31:13Z https://doi.org/10.3389/fmicb.2021.688202.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Sesquiterpenoids_From_the_Antarctic_Fungus_Pseudogymnoascus_sp_HSX2_-11_PDF/14768286 unknown doi:10.3389/fmicb.2021.688202.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Sesquiterpenoids_From_the_Antarctic_Fungus_Pseudogymnoascus_sp_HSX2_-11_PDF/14768286 CC BY 4.0 CC-BY Microbiology Microbial Genetics Microbial Ecology Mycology Antarctic fungus Pseudogymnoascus sp. HSX2#-11 sesquiterpenoids steroids cytotoxicity antibacterial activity Dataset 2021 ftfrontimediafig https://doi.org/10.3389/fmicb.2021.688202.s001 2021-06-16T23:01:11Z The fungal strains Pseudogymnoascus are a kind of psychrophilic pathogenic fungi that are ubiquitously distributed in Antarctica, while the studies of their secondary metabolites are infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11 led to the isolation of six new tremulane sesquiterpenoids pseudotremulanes A–F (1–6), combined with one known analog 11,12-epoxy-12β-hydroxy-1-tremulen-5-one (7), and five known steroids (8–12). The absolute configurations of the new compounds (1–6) were elucidated by their ECD spectra and ECD calculations. Compounds 1–7 were proved to be isomeride structures with the same chemical formula. Compounds 1/2, 3/4, 1/4, and 2/3 were identified as four pairs of epimerides at the locations of C-3, C-3, C-9, and C-9, respectively. Compounds 8 and 9 exhibited cytotoxic activities against human breast cancer (MDA-MB-231), colorectal cancer (HCT116), and hepatoma (HepG2) cell lines. Compounds 9 and 10 also showed antibacterial activities against marine fouling bacteria Aeromonas salmonicida. This is the first time to find terpenoids and steroids in the fungal genus Pseudogymnoascus. Dataset Antarc* Antarctic Antarctica Frontiers: Figshare Antarctic The Antarctic |
institution |
Open Polar |
collection |
Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Microbiology Microbial Genetics Microbial Ecology Mycology Antarctic fungus Pseudogymnoascus sp. HSX2#-11 sesquiterpenoids steroids cytotoxicity antibacterial activity |
spellingShingle |
Microbiology Microbial Genetics Microbial Ecology Mycology Antarctic fungus Pseudogymnoascus sp. HSX2#-11 sesquiterpenoids steroids cytotoxicity antibacterial activity Ting Shi Xiang-Qian Li Li Zheng Ya-Hui Zhang Jia-Jia Dai Er-Lei Shang Yan-Yan Yu Yi-Ting Zhang Wen-Peng Hu Da-Yong Shi Data_Sheet_1_Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.PDF |
topic_facet |
Microbiology Microbial Genetics Microbial Ecology Mycology Antarctic fungus Pseudogymnoascus sp. HSX2#-11 sesquiterpenoids steroids cytotoxicity antibacterial activity |
description |
The fungal strains Pseudogymnoascus are a kind of psychrophilic pathogenic fungi that are ubiquitously distributed in Antarctica, while the studies of their secondary metabolites are infrequent. Systematic research of the metabolites of the fungus Pseudogymnoascus sp. HSX2#-11 led to the isolation of six new tremulane sesquiterpenoids pseudotremulanes A–F (1–6), combined with one known analog 11,12-epoxy-12β-hydroxy-1-tremulen-5-one (7), and five known steroids (8–12). The absolute configurations of the new compounds (1–6) were elucidated by their ECD spectra and ECD calculations. Compounds 1–7 were proved to be isomeride structures with the same chemical formula. Compounds 1/2, 3/4, 1/4, and 2/3 were identified as four pairs of epimerides at the locations of C-3, C-3, C-9, and C-9, respectively. Compounds 8 and 9 exhibited cytotoxic activities against human breast cancer (MDA-MB-231), colorectal cancer (HCT116), and hepatoma (HepG2) cell lines. Compounds 9 and 10 also showed antibacterial activities against marine fouling bacteria Aeromonas salmonicida. This is the first time to find terpenoids and steroids in the fungal genus Pseudogymnoascus. |
format |
Dataset |
author |
Ting Shi Xiang-Qian Li Li Zheng Ya-Hui Zhang Jia-Jia Dai Er-Lei Shang Yan-Yan Yu Yi-Ting Zhang Wen-Peng Hu Da-Yong Shi |
author_facet |
Ting Shi Xiang-Qian Li Li Zheng Ya-Hui Zhang Jia-Jia Dai Er-Lei Shang Yan-Yan Yu Yi-Ting Zhang Wen-Peng Hu Da-Yong Shi |
author_sort |
Ting Shi |
title |
Data_Sheet_1_Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.PDF |
title_short |
Data_Sheet_1_Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.PDF |
title_full |
Data_Sheet_1_Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.PDF |
title_fullStr |
Data_Sheet_1_Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.PDF |
title_full_unstemmed |
Data_Sheet_1_Sesquiterpenoids From the Antarctic Fungus Pseudogymnoascus sp. HSX2#-11.PDF |
title_sort |
data_sheet_1_sesquiterpenoids from the antarctic fungus pseudogymnoascus sp. hsx2#-11.pdf |
publishDate |
2021 |
url |
https://doi.org/10.3389/fmicb.2021.688202.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Sesquiterpenoids_From_the_Antarctic_Fungus_Pseudogymnoascus_sp_HSX2_-11_PDF/14768286 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_relation |
doi:10.3389/fmicb.2021.688202.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Sesquiterpenoids_From_the_Antarctic_Fungus_Pseudogymnoascus_sp_HSX2_-11_PDF/14768286 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fmicb.2021.688202.s001 |
_version_ |
1766084283593654272 |