Data_Sheet_1_Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.PDF
A disproportionate number of Greenland's Inuit population are chronically infected with Hepatitis B virus (HBV; 5–10%). HBV genotypes B and D are most prevalent in the circumpolar Arctic. Here, we report 39 novel HBV/D sequences from individuals residing in southwestern Greenland. We performed...
Main Authors: | , , , , , , , |
---|---|
Format: | Dataset |
Language: | unknown |
Published: |
2021
|
Subjects: | |
Online Access: | https://doi.org/10.3389/fmicb.2020.602296.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Analysis_of_Hepatitis_B_Virus_Genotype_D_in_Greenland_Suggests_the_Presence_of_a_Novel_Quasi-Subgenotype_PDF/13579604 |
id |
ftfrontimediafig:oai:figshare.com:article/13579604 |
---|---|
record_format |
openpolar |
spelling |
ftfrontimediafig:oai:figshare.com:article/13579604 2023-05-15T15:05:08+02:00 Data_Sheet_1_Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.PDF Adriano de Bernardi Schneider Carla Osiowy Reilly Hostager Henrik Krarup Malene Børresen Yasuhito Tanaka Taylor Morriseau Joel O. Wertheim 2021-01-15T05:07:04Z https://doi.org/10.3389/fmicb.2020.602296.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Analysis_of_Hepatitis_B_Virus_Genotype_D_in_Greenland_Suggests_the_Presence_of_a_Novel_Quasi-Subgenotype_PDF/13579604 unknown doi:10.3389/fmicb.2020.602296.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Analysis_of_Hepatitis_B_Virus_Genotype_D_in_Greenland_Suggests_the_Presence_of_a_Novel_Quasi-Subgenotype_PDF/13579604 CC BY 4.0 CC-BY Microbiology Microbial Genetics Microbial Ecology Mycology evolution HBV phylogenetics phylogenomics hepatitis Dataset 2021 ftfrontimediafig https://doi.org/10.3389/fmicb.2020.602296.s001 2021-01-20T23:59:57Z A disproportionate number of Greenland's Inuit population are chronically infected with Hepatitis B virus (HBV; 5–10%). HBV genotypes B and D are most prevalent in the circumpolar Arctic. Here, we report 39 novel HBV/D sequences from individuals residing in southwestern Greenland. We performed phylodynamic analyses with ancient HBV DNA calibrators to investigate the origin and relationship of these taxa to other HBV sequences. We inferred a substitution rate of 1.4 × 10 −5 [95% HPD 8.8 × 10 −6 , 2.0 × 10 −5 ] and a time to the most recent common ancestor of 629 CE [95% HPD 37–1138 CE]. The Greenland taxa form a sister clade to HBV/D2 sequences, specifically New Caledonian and Indigenous Taiwanese sequences. The Greenland sequences share amino acid signatures with subgenotypes D1 and D2 and ~97% sequence identity. Our results suggest the classification of these novel sequences does not fit within the current nomenclature. Thus, we propose these taxa be considered a novel quasi-subgenotype. Dataset Arctic Greenland inuit Frontiers: Figshare Arctic Greenland |
institution |
Open Polar |
collection |
Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Microbiology Microbial Genetics Microbial Ecology Mycology evolution HBV phylogenetics phylogenomics hepatitis |
spellingShingle |
Microbiology Microbial Genetics Microbial Ecology Mycology evolution HBV phylogenetics phylogenomics hepatitis Adriano de Bernardi Schneider Carla Osiowy Reilly Hostager Henrik Krarup Malene Børresen Yasuhito Tanaka Taylor Morriseau Joel O. Wertheim Data_Sheet_1_Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.PDF |
topic_facet |
Microbiology Microbial Genetics Microbial Ecology Mycology evolution HBV phylogenetics phylogenomics hepatitis |
description |
A disproportionate number of Greenland's Inuit population are chronically infected with Hepatitis B virus (HBV; 5–10%). HBV genotypes B and D are most prevalent in the circumpolar Arctic. Here, we report 39 novel HBV/D sequences from individuals residing in southwestern Greenland. We performed phylodynamic analyses with ancient HBV DNA calibrators to investigate the origin and relationship of these taxa to other HBV sequences. We inferred a substitution rate of 1.4 × 10 −5 [95% HPD 8.8 × 10 −6 , 2.0 × 10 −5 ] and a time to the most recent common ancestor of 629 CE [95% HPD 37–1138 CE]. The Greenland taxa form a sister clade to HBV/D2 sequences, specifically New Caledonian and Indigenous Taiwanese sequences. The Greenland sequences share amino acid signatures with subgenotypes D1 and D2 and ~97% sequence identity. Our results suggest the classification of these novel sequences does not fit within the current nomenclature. Thus, we propose these taxa be considered a novel quasi-subgenotype. |
format |
Dataset |
author |
Adriano de Bernardi Schneider Carla Osiowy Reilly Hostager Henrik Krarup Malene Børresen Yasuhito Tanaka Taylor Morriseau Joel O. Wertheim |
author_facet |
Adriano de Bernardi Schneider Carla Osiowy Reilly Hostager Henrik Krarup Malene Børresen Yasuhito Tanaka Taylor Morriseau Joel O. Wertheim |
author_sort |
Adriano de Bernardi Schneider |
title |
Data_Sheet_1_Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.PDF |
title_short |
Data_Sheet_1_Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.PDF |
title_full |
Data_Sheet_1_Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.PDF |
title_fullStr |
Data_Sheet_1_Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.PDF |
title_full_unstemmed |
Data_Sheet_1_Analysis of Hepatitis B Virus Genotype D in Greenland Suggests the Presence of a Novel Quasi-Subgenotype.PDF |
title_sort |
data_sheet_1_analysis of hepatitis b virus genotype d in greenland suggests the presence of a novel quasi-subgenotype.pdf |
publishDate |
2021 |
url |
https://doi.org/10.3389/fmicb.2020.602296.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Analysis_of_Hepatitis_B_Virus_Genotype_D_in_Greenland_Suggests_the_Presence_of_a_Novel_Quasi-Subgenotype_PDF/13579604 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Greenland inuit |
genre_facet |
Arctic Greenland inuit |
op_relation |
doi:10.3389/fmicb.2020.602296.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Analysis_of_Hepatitis_B_Virus_Genotype_D_in_Greenland_Suggests_the_Presence_of_a_Novel_Quasi-Subgenotype_PDF/13579604 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fmicb.2020.602296.s001 |
_version_ |
1766336889819758592 |