DataSheet_1_CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues.pdf
Lumpfish (Cyclopterus lumpus), a North Atlantic “cleaner“ fish, is utilized to biocontrol salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar) farms. Lumpfish require excellent vision to scan for and eat louse on salmon skin. The lumpfish eye immune response to infectious diseases...
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ftfrontimediafig:oai:figshare.com:article/13264421 2023-05-15T15:32:40+02:00 DataSheet_1_CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues.pdf Robert L. Gendron Hélène Paradis Raahyma Ahmad Kenneth Kao Danny Boyce William V. Good Surendra Kumar Ignacio Vasquez Trung Cao Ahmed Hossain Setu Chakraborty Katherinne Valderrama Javier Santander 2020-11-20T04:50:28Z https://doi.org/10.3389/fimmu.2020.576897.s001 https://figshare.com/articles/dataset/DataSheet_1_CD10_Cells_and_IgM_in_Pathogen_Response_in_Lumpfish_Cyclopterus_lumpus_Eye_Tissues_pdf/13264421 unknown doi:10.3389/fimmu.2020.576897.s001 https://figshare.com/articles/dataset/DataSheet_1_CD10_Cells_and_IgM_in_Pathogen_Response_in_Lumpfish_Cyclopterus_lumpus_Eye_Tissues_pdf/13264421 CC BY 4.0 CC-BY Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology lumpfish (Cyclopterus lumpus L.) eye immune response infection cluster of differentiation 10 immunoglobulin M Dataset 2020 ftfrontimediafig https://doi.org/10.3389/fimmu.2020.576897.s001 2020-11-25T23:57:49Z Lumpfish (Cyclopterus lumpus), a North Atlantic “cleaner“ fish, is utilized to biocontrol salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar) farms. Lumpfish require excellent vision to scan for and eat louse on salmon skin. The lumpfish eye immune response to infectious diseases has not been explored. We examined the ocular response to a natural parasite infection in wild lumpfish and to an experimental bacterial infection in cultured lumpfish. Cysts associated with natural myxozoan infection in the ocular scleral cartilage of wild adult lumpfish harbored cells expressing cluster of differentiation 10 (CD10) and immunoglobulin M (IgM). Experimental Vibrio anguillarum infection, which led to exophthalmos and disorganization of the retinal tissues was associated with disruption of normal CD10 expression, CD10 + cellular infiltration and IgM expression. We further describe the lumpfish CD10 orthologue and characterize the lumpfish scleral skeleton in the context of myxozoan scleral cysts. We propose that lumpfish develop an intraocular response to pathogens, exemplified herein by myxozoan and V. anguillarum infection involving novel CD10 + cells and IgM + cells to contain and mitigate damage to eye structures. This work is the first demonstration of CD10 and IgM expressing cells in a novel ocular immune system component in response to disease in a teleost. Dataset Atlantic salmon North Atlantic Salmo salar Frontiers: Figshare |
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Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology lumpfish (Cyclopterus lumpus L.) eye immune response infection cluster of differentiation 10 immunoglobulin M |
spellingShingle |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology lumpfish (Cyclopterus lumpus L.) eye immune response infection cluster of differentiation 10 immunoglobulin M Robert L. Gendron Hélène Paradis Raahyma Ahmad Kenneth Kao Danny Boyce William V. Good Surendra Kumar Ignacio Vasquez Trung Cao Ahmed Hossain Setu Chakraborty Katherinne Valderrama Javier Santander DataSheet_1_CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues.pdf |
topic_facet |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology lumpfish (Cyclopterus lumpus L.) eye immune response infection cluster of differentiation 10 immunoglobulin M |
description |
Lumpfish (Cyclopterus lumpus), a North Atlantic “cleaner“ fish, is utilized to biocontrol salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar) farms. Lumpfish require excellent vision to scan for and eat louse on salmon skin. The lumpfish eye immune response to infectious diseases has not been explored. We examined the ocular response to a natural parasite infection in wild lumpfish and to an experimental bacterial infection in cultured lumpfish. Cysts associated with natural myxozoan infection in the ocular scleral cartilage of wild adult lumpfish harbored cells expressing cluster of differentiation 10 (CD10) and immunoglobulin M (IgM). Experimental Vibrio anguillarum infection, which led to exophthalmos and disorganization of the retinal tissues was associated with disruption of normal CD10 expression, CD10 + cellular infiltration and IgM expression. We further describe the lumpfish CD10 orthologue and characterize the lumpfish scleral skeleton in the context of myxozoan scleral cysts. We propose that lumpfish develop an intraocular response to pathogens, exemplified herein by myxozoan and V. anguillarum infection involving novel CD10 + cells and IgM + cells to contain and mitigate damage to eye structures. This work is the first demonstration of CD10 and IgM expressing cells in a novel ocular immune system component in response to disease in a teleost. |
format |
Dataset |
author |
Robert L. Gendron Hélène Paradis Raahyma Ahmad Kenneth Kao Danny Boyce William V. Good Surendra Kumar Ignacio Vasquez Trung Cao Ahmed Hossain Setu Chakraborty Katherinne Valderrama Javier Santander |
author_facet |
Robert L. Gendron Hélène Paradis Raahyma Ahmad Kenneth Kao Danny Boyce William V. Good Surendra Kumar Ignacio Vasquez Trung Cao Ahmed Hossain Setu Chakraborty Katherinne Valderrama Javier Santander |
author_sort |
Robert L. Gendron |
title |
DataSheet_1_CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues.pdf |
title_short |
DataSheet_1_CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues.pdf |
title_full |
DataSheet_1_CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues.pdf |
title_fullStr |
DataSheet_1_CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues.pdf |
title_full_unstemmed |
DataSheet_1_CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues.pdf |
title_sort |
datasheet_1_cd10+ cells and igm in pathogen response in lumpfish (cyclopterus lumpus) eye tissues.pdf |
publishDate |
2020 |
url |
https://doi.org/10.3389/fimmu.2020.576897.s001 https://figshare.com/articles/dataset/DataSheet_1_CD10_Cells_and_IgM_in_Pathogen_Response_in_Lumpfish_Cyclopterus_lumpus_Eye_Tissues_pdf/13264421 |
genre |
Atlantic salmon North Atlantic Salmo salar |
genre_facet |
Atlantic salmon North Atlantic Salmo salar |
op_relation |
doi:10.3389/fimmu.2020.576897.s001 https://figshare.com/articles/dataset/DataSheet_1_CD10_Cells_and_IgM_in_Pathogen_Response_in_Lumpfish_Cyclopterus_lumpus_Eye_Tissues_pdf/13264421 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fimmu.2020.576897.s001 |
_version_ |
1766363160093130752 |