Data_Sheet_1_Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection.PDF

• Main Authors: Shiferaw Jenberie, Ma. Michelle D. Peñaranda, Hanna L. Thim, Morten Bay Styrvold, Guro Strandskog, Jorunn B. Jørgensen, Ingvill Jensen
• Format: Dataset
• Language: unknown
• Published: 2020
• Subjects: Immunology; Applied Immunology (incl. Antibody Engineering; Xenotransplantation and T-cell Therapies); Autoimmunity; Cellular Immunology; Humoural Immunology and Immunochemistry; Immunogenetics (incl. Genetic Immunology); Innate Immunity; Transplantation Immunology; Tumour Immunology; Immunology not elsewhere classified; Genetic Immunology; Animal Immunology; Veterinary Immunology; antibody secreting cells; Atlantic salmon; B cells; peritoneal cavity; Salmonid alphavirus; teleost; Salmo salar
• Online Access: https://doi.org/10.3389/fimmu.2020.01682.s001; https://figshare.com/articles/dataset/Data_Sheet_1_Salmonid_Alphavirus_Subtype_3_Induces_Prolonged_Local_B_Cell_Responses_in_Atlantic_Salmon_Salmo_salar_After_Intraperitoneal_Infection_PDF/12935726

B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon (Salmo salar) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal (IP) infection with SAV3 as a model to characterize local B cell responses in the peritoneal cavity (PerC) and systemic immune tissues (head kidney/spleen). Intraperitoneal administration of vaccines is common in Atlantic salmon and understanding more about the local PerC B cell response is fundamental. Intraperitoneal SAV3 infection clearly induced PerC B cell responses as assessed by increased frequency of IgM + B cells and total IgM secreting cells (ASC). These PerC responses were prolonged up to nine weeks post-infection and positively correlated to the anti-SAV3 E2 and to neutralizing antibody responses in serum. For the systemic immune sites, virus-induced changes in B cell responses were more modest or decreased compared to controls in the same period. Collectively, data reported herein indicated that PerC could serve as a peripheral immunological site by providing a niche for prolonged maintenance of the ASC response in Atlantic salmon.