Table_2_The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense.XLSX
The salmon gill poxvirus (SGPV) is a large DNA virus that infects gill epithelial cells in Atlantic salmon and is associated with acute high mortality disease outbreaks in aquaculture. The pathological effects of SGPV infection include gill epithelial apoptosis in the acute phase of the disease and...
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ftfrontimediafig:oai:figshare.com:article/12917549 2023-05-15T15:30:32+02:00 Table_2_The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense.XLSX Mona C. Gjessing Aleksei Krasnov Gerrit Timmerhaus Svante Brun Sergey Afanasyev Ole Bendik Dale Maria K. Dahle 2020-09-04T07:35:30Z https://doi.org/10.3389/fimmu.2020.02154.s002 https://figshare.com/articles/dataset/Table_2_The_Atlantic_Salmon_Gill_Transcriptome_Response_in_a_Natural_Outbreak_of_Salmon_Gill_Pox_Virus_Infection_Reveals_New_Biomarkers_of_Gill_Pathology_and_Suppression_of_Mucosal_Defense_XLSX/12917549 unknown doi:10.3389/fimmu.2020.02154.s002 https://figshare.com/articles/dataset/Table_2_The_Atlantic_Salmon_Gill_Transcriptome_Response_in_a_Natural_Outbreak_of_Salmon_Gill_Pox_Virus_Infection_Reveals_New_Biomarkers_of_Gill_Pathology_and_Suppression_of_Mucosal_Defense_XLSX/12917549 Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology salmon gill poxvirus Atlantic salmon gill disease transcriptome aquaculture smoltification Dataset 2020 ftfrontimediafig https://doi.org/10.3389/fimmu.2020.02154.s002 2020-09-09T22:55:58Z The salmon gill poxvirus (SGPV) is a large DNA virus that infects gill epithelial cells in Atlantic salmon and is associated with acute high mortality disease outbreaks in aquaculture. The pathological effects of SGPV infection include gill epithelial apoptosis in the acute phase of the disease and hyperplasia of gill epithelial cells in surviving fish, causing damage to the gill respiratory surface. In this study, we sampled gills from Atlantic salmon presmolts during a natural outbreak of SGPV disease (SGPVD). Samples covered the early phase of infection, the acute mortality phase, the resolving phase of the disease and control fish from the same group and facility. Mortality, the presence and level of SGPV and gill epithelial apoptosis were clearly associated. The gene expression pattern in the acute phase of SGPVD was in tune with the pathological findings and revealed novel transcript-based disease biomarkers, including pro-apoptotic and proliferative genes, along with changes in expression of ion channels and mucins. The innate antiviral response was strongly upregulated in infected gills and chemokine expression was altered. The regenerating phase did not reveal adaptive immune activity within the study period, but several immune effector genes involved in mucosal protection were downregulated into the late phase, indicating that SGPV infection could compromise mucosal defense. These data provide novel insight into the infection mechanisms and host interaction of SGPV. Dataset Atlantic salmon Frontiers: Figshare |
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Frontiers: Figshare |
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ftfrontimediafig |
language |
unknown |
topic |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology salmon gill poxvirus Atlantic salmon gill disease transcriptome aquaculture smoltification |
spellingShingle |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology salmon gill poxvirus Atlantic salmon gill disease transcriptome aquaculture smoltification Mona C. Gjessing Aleksei Krasnov Gerrit Timmerhaus Svante Brun Sergey Afanasyev Ole Bendik Dale Maria K. Dahle Table_2_The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense.XLSX |
topic_facet |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology salmon gill poxvirus Atlantic salmon gill disease transcriptome aquaculture smoltification |
description |
The salmon gill poxvirus (SGPV) is a large DNA virus that infects gill epithelial cells in Atlantic salmon and is associated with acute high mortality disease outbreaks in aquaculture. The pathological effects of SGPV infection include gill epithelial apoptosis in the acute phase of the disease and hyperplasia of gill epithelial cells in surviving fish, causing damage to the gill respiratory surface. In this study, we sampled gills from Atlantic salmon presmolts during a natural outbreak of SGPV disease (SGPVD). Samples covered the early phase of infection, the acute mortality phase, the resolving phase of the disease and control fish from the same group and facility. Mortality, the presence and level of SGPV and gill epithelial apoptosis were clearly associated. The gene expression pattern in the acute phase of SGPVD was in tune with the pathological findings and revealed novel transcript-based disease biomarkers, including pro-apoptotic and proliferative genes, along with changes in expression of ion channels and mucins. The innate antiviral response was strongly upregulated in infected gills and chemokine expression was altered. The regenerating phase did not reveal adaptive immune activity within the study period, but several immune effector genes involved in mucosal protection were downregulated into the late phase, indicating that SGPV infection could compromise mucosal defense. These data provide novel insight into the infection mechanisms and host interaction of SGPV. |
format |
Dataset |
author |
Mona C. Gjessing Aleksei Krasnov Gerrit Timmerhaus Svante Brun Sergey Afanasyev Ole Bendik Dale Maria K. Dahle |
author_facet |
Mona C. Gjessing Aleksei Krasnov Gerrit Timmerhaus Svante Brun Sergey Afanasyev Ole Bendik Dale Maria K. Dahle |
author_sort |
Mona C. Gjessing |
title |
Table_2_The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense.XLSX |
title_short |
Table_2_The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense.XLSX |
title_full |
Table_2_The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense.XLSX |
title_fullStr |
Table_2_The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense.XLSX |
title_full_unstemmed |
Table_2_The Atlantic Salmon Gill Transcriptome Response in a Natural Outbreak of Salmon Gill Pox Virus Infection Reveals New Biomarkers of Gill Pathology and Suppression of Mucosal Defense.XLSX |
title_sort |
table_2_the atlantic salmon gill transcriptome response in a natural outbreak of salmon gill pox virus infection reveals new biomarkers of gill pathology and suppression of mucosal defense.xlsx |
publishDate |
2020 |
url |
https://doi.org/10.3389/fimmu.2020.02154.s002 https://figshare.com/articles/dataset/Table_2_The_Atlantic_Salmon_Gill_Transcriptome_Response_in_a_Natural_Outbreak_of_Salmon_Gill_Pox_Virus_Infection_Reveals_New_Biomarkers_of_Gill_Pathology_and_Suppression_of_Mucosal_Defense_XLSX/12917549 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
doi:10.3389/fimmu.2020.02154.s002 https://figshare.com/articles/dataset/Table_2_The_Atlantic_Salmon_Gill_Transcriptome_Response_in_a_Natural_Outbreak_of_Salmon_Gill_Pox_Virus_Infection_Reveals_New_Biomarkers_of_Gill_Pathology_and_Suppression_of_Mucosal_Defense_XLSX/12917549 |
op_doi |
https://doi.org/10.3389/fimmu.2020.02154.s002 |
_version_ |
1766360984567414784 |