Table_4_The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses.xls
Studies on invertebrate immune receptors can provide insights into characteristics specific to innate immune system. Here, eight α and three β integrins are identified from an invertebrate, the Pacific oyster Crassostrea gigas, and their possible immune functions are studied. Oyster α/β integrins ex...
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ftfrontimediafig:oai:figshare.com:article/12694868 2023-05-15T15:57:57+02:00 Table_4_The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses.xls Zhao Lv Limei Qiu Weilin Wang Zhaoqun Liu Qing Liu Lingling Wang Linsheng Song 2020-07-23T04:12:44Z https://doi.org/10.3389/fimmu.2020.01420.s005 https://figshare.com/articles/dataset/Table_4_The_Members_of_the_Highly_Diverse_Crassostrea_gigas_Integrin_Family_Cooperate_for_the_Generation_of_Various_Immune_Responses_xls/12694868 unknown doi:10.3389/fimmu.2020.01420.s005 https://figshare.com/articles/dataset/Table_4_The_Members_of_the_Highly_Diverse_Crassostrea_gigas_Integrin_Family_Cooperate_for_the_Generation_of_Various_Immune_Responses_xls/12694868 CC BY 4.0 CC-BY Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology Crassostrea gigas integrin family immune function ECM ligand binding functional division and cooperation Dataset 2020 ftfrontimediafig https://doi.org/10.3389/fimmu.2020.01420.s005 2020-07-29T22:56:19Z Studies on invertebrate immune receptors can provide insights into characteristics specific to innate immune system. Here, eight α and three β integrins are identified from an invertebrate, the Pacific oyster Crassostrea gigas, and their possible immune functions are studied. Oyster α/β integrins exhibit a higher degree of sequence and structural variability than the members from Homo sapiens and Drosophila melanogaster. The analysis reveals that oyster RGD- and laminin-binding receptor homologs are present in the phylogenetic tree of α integrins, but the other six oyster α integrins mainly form a species-specific branch; meanwhile, oyster β integrins are clustered with insect β integrins but distinct from a member from the mollusk Biomphalaria glabrata. Although phylogenetically lacking the important α integrin branches of LDV-binding, PS3-type, and αI-containing integrins, oyster integrins can bind to most ECM ligands, including RGDCP, LDVCP, GFOGERCP, and laminin protein in a distinct binding pattern. Besides, oyster integrins are distributed in different hemocyte subpopulations, while only specific integrins are selectively involved in hemocyte phagocytosis, migration, and encapsulation, and some of them participate in more than one immune response in a sophisticated pattern. Especially, oyster β integrins are arranged in the core to mediate complex immune responses, unlike the counterparts in humans that mainly depend on αI-containing integrins to incite immune reactions. This study represents the first comprehensive attempt to reveal the structural and evolutionary features of the integrin family and their involvement in cellular immune responses in the non-model invertebrate C. gigas and sheds light on the characteristics specific to the innate immune system in the integrin family. Dataset Crassostrea gigas Pacific oyster Frontiers: Figshare Pacific |
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Open Polar |
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Frontiers: Figshare |
op_collection_id |
ftfrontimediafig |
language |
unknown |
topic |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology Crassostrea gigas integrin family immune function ECM ligand binding functional division and cooperation |
spellingShingle |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology Crassostrea gigas integrin family immune function ECM ligand binding functional division and cooperation Zhao Lv Limei Qiu Weilin Wang Zhaoqun Liu Qing Liu Lingling Wang Linsheng Song Table_4_The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses.xls |
topic_facet |
Immunology Applied Immunology (incl. Antibody Engineering Xenotransplantation and T-cell Therapies) Autoimmunity Cellular Immunology Humoural Immunology and Immunochemistry Immunogenetics (incl. Genetic Immunology) Innate Immunity Transplantation Immunology Tumour Immunology Immunology not elsewhere classified Genetic Immunology Animal Immunology Veterinary Immunology Crassostrea gigas integrin family immune function ECM ligand binding functional division and cooperation |
description |
Studies on invertebrate immune receptors can provide insights into characteristics specific to innate immune system. Here, eight α and three β integrins are identified from an invertebrate, the Pacific oyster Crassostrea gigas, and their possible immune functions are studied. Oyster α/β integrins exhibit a higher degree of sequence and structural variability than the members from Homo sapiens and Drosophila melanogaster. The analysis reveals that oyster RGD- and laminin-binding receptor homologs are present in the phylogenetic tree of α integrins, but the other six oyster α integrins mainly form a species-specific branch; meanwhile, oyster β integrins are clustered with insect β integrins but distinct from a member from the mollusk Biomphalaria glabrata. Although phylogenetically lacking the important α integrin branches of LDV-binding, PS3-type, and αI-containing integrins, oyster integrins can bind to most ECM ligands, including RGDCP, LDVCP, GFOGERCP, and laminin protein in a distinct binding pattern. Besides, oyster integrins are distributed in different hemocyte subpopulations, while only specific integrins are selectively involved in hemocyte phagocytosis, migration, and encapsulation, and some of them participate in more than one immune response in a sophisticated pattern. Especially, oyster β integrins are arranged in the core to mediate complex immune responses, unlike the counterparts in humans that mainly depend on αI-containing integrins to incite immune reactions. This study represents the first comprehensive attempt to reveal the structural and evolutionary features of the integrin family and their involvement in cellular immune responses in the non-model invertebrate C. gigas and sheds light on the characteristics specific to the innate immune system in the integrin family. |
format |
Dataset |
author |
Zhao Lv Limei Qiu Weilin Wang Zhaoqun Liu Qing Liu Lingling Wang Linsheng Song |
author_facet |
Zhao Lv Limei Qiu Weilin Wang Zhaoqun Liu Qing Liu Lingling Wang Linsheng Song |
author_sort |
Zhao Lv |
title |
Table_4_The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses.xls |
title_short |
Table_4_The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses.xls |
title_full |
Table_4_The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses.xls |
title_fullStr |
Table_4_The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses.xls |
title_full_unstemmed |
Table_4_The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses.xls |
title_sort |
table_4_the members of the highly diverse crassostrea gigas integrin family cooperate for the generation of various immune responses.xls |
publishDate |
2020 |
url |
https://doi.org/10.3389/fimmu.2020.01420.s005 https://figshare.com/articles/dataset/Table_4_The_Members_of_the_Highly_Diverse_Crassostrea_gigas_Integrin_Family_Cooperate_for_the_Generation_of_Various_Immune_Responses_xls/12694868 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
doi:10.3389/fimmu.2020.01420.s005 https://figshare.com/articles/dataset/Table_4_The_Members_of_the_Highly_Diverse_Crassostrea_gigas_Integrin_Family_Cooperate_for_the_Generation_of_Various_Immune_Responses_xls/12694868 |
op_rights |
CC BY 4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.3389/fimmu.2020.01420.s005 |
_version_ |
1766393657753075712 |