Bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (Salmo salar) in Southern Chile
S.6012-6018 Infectious salmon anemia (ISA) is a severe disease that affects farmed Atlantic salmon (Salmo salar), causing outbreaks in sea-water in most salmon-producing countries worldwide, with particular aggressiveness in southern Chile. The etiological agent of this disease is a virus belonging...
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ftfrauneprints:oai:publica.fraunhofer.de:publica/236244 2024-05-19T07:37:40+00:00 Bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (Salmo salar) in Southern Chile Marshall, S.H. Ramirez, R. Labra, A. Carmona, M. Munoz, C. 2014 https://publica.fraunhofer.de/handle/publica/236244 https://doi.org/10.1128/JVI.03670-13 en eng Journal of virology doi:10.1128/JVI.03670-13 https://publica.fraunhofer.de/handle/publica/236244 579 journal article 2014 ftfrauneprints https://doi.org/10.1128/JVI.03670-13 2024-04-24T00:14:51Z S.6012-6018 Infectious salmon anemia (ISA) is a severe disease that affects farmed Atlantic salmon (Salmo salar), causing outbreaks in sea-water in most salmon-producing countries worldwide, with particular aggressiveness in southern Chile. The etiological agent of this disease is a virus belonging to the Orthomyxoviridae family, named infectious salmon anemia virus (ISAV). Although it has been suggested that this virus can be vertically transmitted, even in freshwater, there is a lack of compelling experimental evidence to confirm this. Here we demonstrate significant putative viral loads in the ovarian fluid as well as in the eggs of two brood stock female adult specimens that harbored the virus systemically but without clinical signs. The target virus corresponded to a highly polymorphic region 3 (HPR-3) variant, which is known to be virulent in seawater and responsible for recent and past outbreaks of this disease in Chile. Additionally, the virus recovered from the fluid as well as from the interior of the eggs was fully infective to a susceptible fish cell line. To our knowledge, this is the first robust evidence demonstrating mother-to-offspring vertical transmission of the infective virus on the one hand and the asymptomatic transmission of a virulent form of the virus in freshwater fish on the other hand. 88 Nr.11 Article in Journal/Newspaper Atlantic salmon Salmo salar Publikationsdatenbank der Fraunhofer-Gesellschaft Journal of Virology 88 11 6012 6018 |
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English |
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579 Marshall, S.H. Ramirez, R. Labra, A. Carmona, M. Munoz, C. Bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (Salmo salar) in Southern Chile |
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description |
S.6012-6018 Infectious salmon anemia (ISA) is a severe disease that affects farmed Atlantic salmon (Salmo salar), causing outbreaks in sea-water in most salmon-producing countries worldwide, with particular aggressiveness in southern Chile. The etiological agent of this disease is a virus belonging to the Orthomyxoviridae family, named infectious salmon anemia virus (ISAV). Although it has been suggested that this virus can be vertically transmitted, even in freshwater, there is a lack of compelling experimental evidence to confirm this. Here we demonstrate significant putative viral loads in the ovarian fluid as well as in the eggs of two brood stock female adult specimens that harbored the virus systemically but without clinical signs. The target virus corresponded to a highly polymorphic region 3 (HPR-3) variant, which is known to be virulent in seawater and responsible for recent and past outbreaks of this disease in Chile. Additionally, the virus recovered from the fluid as well as from the interior of the eggs was fully infective to a susceptible fish cell line. To our knowledge, this is the first robust evidence demonstrating mother-to-offspring vertical transmission of the infective virus on the one hand and the asymptomatic transmission of a virulent form of the virus in freshwater fish on the other hand. 88 Nr.11 |
format |
Article in Journal/Newspaper |
author |
Marshall, S.H. Ramirez, R. Labra, A. Carmona, M. Munoz, C. |
author_facet |
Marshall, S.H. Ramirez, R. Labra, A. Carmona, M. Munoz, C. |
author_sort |
Marshall, S.H. |
title |
Bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (Salmo salar) in Southern Chile |
title_short |
Bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (Salmo salar) in Southern Chile |
title_full |
Bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (Salmo salar) in Southern Chile |
title_fullStr |
Bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (Salmo salar) in Southern Chile |
title_full_unstemmed |
Bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (Salmo salar) in Southern Chile |
title_sort |
bona fide evidence for natural vertical transmission of infectious salmon anemia virus in freshwater brood stocks of farmed atlantic salmon (salmo salar) in southern chile |
publishDate |
2014 |
url |
https://publica.fraunhofer.de/handle/publica/236244 https://doi.org/10.1128/JVI.03670-13 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
Journal of virology doi:10.1128/JVI.03670-13 https://publica.fraunhofer.de/handle/publica/236244 |
op_doi |
https://doi.org/10.1128/JVI.03670-13 |
container_title |
Journal of Virology |
container_volume |
88 |
container_issue |
11 |
container_start_page |
6012 |
op_container_end_page |
6018 |
_version_ |
1799477010123194368 |