Transmissible Tumors: Breaking the Cancer Paradigm.
Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching are transfer mechanisms for the two primary spe...
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ftfloridasu:oai:diginole.lib.fsu.edu:fsu_620327 2024-06-09T07:45:18+00:00 Transmissible Tumors: Breaking the Cancer Paradigm. Ostrander, Elaine A (authoraut) Davis, Brian W (authoraut) Ostrander, Gary K (authoraut) 2016-01-01 1 online resource computer https://diginole.lib.fsu.edu/islandora/object/fsu%3A620327/datastream/TN/view/Transmissible%20Tumors.jpg English eng eng Trends in genetics : TIG--0168-9525 fsu:620327 (IID) FSU_pmch_26686413 (DOI) 10.1016/j.tig.2015.10.001 (PMCID) PMC4698198 (RID) 26686413 (EID) 26686413 (PII) S0168-9525(15)00187-0 https://diginole.lib.fsu.edu/islandora/object/fsu%3A620327/datastream/TN/view/Transmissible%20Tumors.jpg Animals Biological Evolution Dog Diseases/transmission Dogs Facial Neoplasms/veterinary Genetic Variation Marsupialia Mesocricetus Mya Neoplasms/genetics Neoplasms/immunology Neoplasms/veterinary Venereal Tumors Veterinary Text journal article 2016 ftfloridasu 2024-05-10T08:08:10Z Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching are transfer mechanisms for the two primary species studied, the domestic dog (Canis lupus familiaris) and the Tasmanian devil (Sarcophilus harrisii). Canine transmissible venereal tumors (CTVT) are likely thousands of years old, and have successfully travelled from host to host around the world, while the Tasmanian devil facial tumor disease (DFTD) is much younger and geographically localized. The dog tumor is not necessarily lethal, while the devil tumor has driven the population to near extinction. Transmissible tumors are uniform in that they have complex immunologic profiles, which allow them to escape immune detection by their hosts, sometimes for long periods of time. In this review, we explore how transmissible tumors in CTVT, DFTD, and as well as the soft-shell clam and Syrian hamster, can advance studies of tumor biology. Keywords: Cancer, Canine, Clonal, Devil, Infectious, Transmissible Grant Number: ZIA HG200325-06 Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698198. Article in Journal/Newspaper Canis lupus Florida State University: DigiNole Commons |
institution |
Open Polar |
collection |
Florida State University: DigiNole Commons |
op_collection_id |
ftfloridasu |
language |
English |
topic |
Animals Biological Evolution Dog Diseases/transmission Dogs Facial Neoplasms/veterinary Genetic Variation Marsupialia Mesocricetus Mya Neoplasms/genetics Neoplasms/immunology Neoplasms/veterinary Venereal Tumors Veterinary |
spellingShingle |
Animals Biological Evolution Dog Diseases/transmission Dogs Facial Neoplasms/veterinary Genetic Variation Marsupialia Mesocricetus Mya Neoplasms/genetics Neoplasms/immunology Neoplasms/veterinary Venereal Tumors Veterinary Transmissible Tumors: Breaking the Cancer Paradigm. |
topic_facet |
Animals Biological Evolution Dog Diseases/transmission Dogs Facial Neoplasms/veterinary Genetic Variation Marsupialia Mesocricetus Mya Neoplasms/genetics Neoplasms/immunology Neoplasms/veterinary Venereal Tumors Veterinary |
description |
Transmissible tumors are those that have transcended the bounds of their incipient hosts by evolving the ability to infect another individual through direct transfer of cancer cells, thus becoming parasitic cancer clones. Coitus, biting, and scratching are transfer mechanisms for the two primary species studied, the domestic dog (Canis lupus familiaris) and the Tasmanian devil (Sarcophilus harrisii). Canine transmissible venereal tumors (CTVT) are likely thousands of years old, and have successfully travelled from host to host around the world, while the Tasmanian devil facial tumor disease (DFTD) is much younger and geographically localized. The dog tumor is not necessarily lethal, while the devil tumor has driven the population to near extinction. Transmissible tumors are uniform in that they have complex immunologic profiles, which allow them to escape immune detection by their hosts, sometimes for long periods of time. In this review, we explore how transmissible tumors in CTVT, DFTD, and as well as the soft-shell clam and Syrian hamster, can advance studies of tumor biology. Keywords: Cancer, Canine, Clonal, Devil, Infectious, Transmissible Grant Number: ZIA HG200325-06 Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698198. |
author2 |
Ostrander, Elaine A (authoraut) Davis, Brian W (authoraut) Ostrander, Gary K (authoraut) |
format |
Article in Journal/Newspaper |
title |
Transmissible Tumors: Breaking the Cancer Paradigm. |
title_short |
Transmissible Tumors: Breaking the Cancer Paradigm. |
title_full |
Transmissible Tumors: Breaking the Cancer Paradigm. |
title_fullStr |
Transmissible Tumors: Breaking the Cancer Paradigm. |
title_full_unstemmed |
Transmissible Tumors: Breaking the Cancer Paradigm. |
title_sort |
transmissible tumors: breaking the cancer paradigm. |
publishDate |
2016 |
url |
https://diginole.lib.fsu.edu/islandora/object/fsu%3A620327/datastream/TN/view/Transmissible%20Tumors.jpg |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
Trends in genetics : TIG--0168-9525 fsu:620327 (IID) FSU_pmch_26686413 (DOI) 10.1016/j.tig.2015.10.001 (PMCID) PMC4698198 (RID) 26686413 (EID) 26686413 (PII) S0168-9525(15)00187-0 https://diginole.lib.fsu.edu/islandora/object/fsu%3A620327/datastream/TN/view/Transmissible%20Tumors.jpg |
_version_ |
1801374587189985280 |