Diversity and selection in the major histocompatibility complex [electronic resource] : DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus) /
The Major Histocompatibility Complex (MHC) encodes proteins critical to the vertebrate immune response; therefore MHC diversity is an indicator of population health. I have (1) Isolated exon 2 of the class II gene DQA in Tursiops truncatus in the North Indian River Lagoon (IRL) (n=17), South IRL (n=...
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ftfloridacla:oai:digitool.fcla.edu:3362335 2023-05-15T17:53:45+02:00 Diversity and selection in the major histocompatibility complex [electronic resource] : DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus) / Ferrer, Tatiana. 2013. http://digitool.fcla.edu:80/R/?func=dbin-jump-full&object_id=3362335 eng eng Major histocompatibility complex. Immunogenetics. Molecular genetics. Endocrine disrupting chemicals. Dolphins Population genetics. Social behavior in animals. text Electronic Thesis or Dissertation 2013 ftfloridacla 2013-10-19T07:19:20Z The Major Histocompatibility Complex (MHC) encodes proteins critical to the vertebrate immune response; therefore MHC diversity is an indicator of population health. I have (1) Isolated exon 2 of the class II gene DQA in Tursiops truncatus in the North Indian River Lagoon (IRL) (n=17), South IRL (n=29) and adjacent Atlantic waters (n=20), (2) assessed genetic variability between groups, (3) developed a method to genotype individuals, (4) typed 11 unique alleles in 66 individuals, (5) detected geographic patterns of diversity between estuarine and coastal individuals (FST=0.1255, p<0.05), (6) found evidence of positive selection centered in the binding pockets P1, P6 and P9 of the peptide binding region (w=2.08), (7) found that patterns of polymorphism did not closely match patterns of diversity in neutral markers, (8) performed a pilot study with Orcinus orca. The initial findings highlight the need for further comparative work and suggest that silent mutations are not neutral. Thesis (M.S.)--Florida Atlantic University, 2013. Includes bibliography. The Major Histocompatibility Complex (MHC) encodes proteins critical to the vertebrate immune response; therefore MHC diversity is an indicator of population health. I have (1) Isolated exon 2 of the class II gene DQA in Tursiops truncatus in the North Indian River Lagoon (IRL) (n=17), South IRL (n=29) and adjacent Atlantic waters (n=20), (2) assessed genetic variability between groups, (3) developed a method to genotype individuals, (4) typed 11 unique alleles in 66 individuals, (5) detected geographic patterns of diversity between estuarine and coastal individuals (FST=0.1255, p<0.05), (6) found evidence of positive selection centered in the binding pockets P1, P6 and P9 of the peptide binding region (w=2.08), (7) found that patterns of polymorphism did not closely match patterns of diversity in neutral markers, (8) performed a pilot study with Orcinus orca. The initial findings highlight the need for further comparative work and suggest that silent mutations are not neutral. Mode of access: World Wide Web. System requirements: Adobe Reader. Thesis Orca Orcinus orca Florida State University: Publication of Archival Library & Museum Materials Indian |
institution |
Open Polar |
collection |
Florida State University: Publication of Archival Library & Museum Materials |
op_collection_id |
ftfloridacla |
language |
English |
topic |
Major histocompatibility complex. Immunogenetics. Molecular genetics. Endocrine disrupting chemicals. Dolphins Population genetics. Social behavior in animals. |
spellingShingle |
Major histocompatibility complex. Immunogenetics. Molecular genetics. Endocrine disrupting chemicals. Dolphins Population genetics. Social behavior in animals. Ferrer, Tatiana. Diversity and selection in the major histocompatibility complex [electronic resource] : DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus) / |
topic_facet |
Major histocompatibility complex. Immunogenetics. Molecular genetics. Endocrine disrupting chemicals. Dolphins Population genetics. Social behavior in animals. |
description |
The Major Histocompatibility Complex (MHC) encodes proteins critical to the vertebrate immune response; therefore MHC diversity is an indicator of population health. I have (1) Isolated exon 2 of the class II gene DQA in Tursiops truncatus in the North Indian River Lagoon (IRL) (n=17), South IRL (n=29) and adjacent Atlantic waters (n=20), (2) assessed genetic variability between groups, (3) developed a method to genotype individuals, (4) typed 11 unique alleles in 66 individuals, (5) detected geographic patterns of diversity between estuarine and coastal individuals (FST=0.1255, p<0.05), (6) found evidence of positive selection centered in the binding pockets P1, P6 and P9 of the peptide binding region (w=2.08), (7) found that patterns of polymorphism did not closely match patterns of diversity in neutral markers, (8) performed a pilot study with Orcinus orca. The initial findings highlight the need for further comparative work and suggest that silent mutations are not neutral. Thesis (M.S.)--Florida Atlantic University, 2013. Includes bibliography. The Major Histocompatibility Complex (MHC) encodes proteins critical to the vertebrate immune response; therefore MHC diversity is an indicator of population health. I have (1) Isolated exon 2 of the class II gene DQA in Tursiops truncatus in the North Indian River Lagoon (IRL) (n=17), South IRL (n=29) and adjacent Atlantic waters (n=20), (2) assessed genetic variability between groups, (3) developed a method to genotype individuals, (4) typed 11 unique alleles in 66 individuals, (5) detected geographic patterns of diversity between estuarine and coastal individuals (FST=0.1255, p<0.05), (6) found evidence of positive selection centered in the binding pockets P1, P6 and P9 of the peptide binding region (w=2.08), (7) found that patterns of polymorphism did not closely match patterns of diversity in neutral markers, (8) performed a pilot study with Orcinus orca. The initial findings highlight the need for further comparative work and suggest that silent mutations are not neutral. Mode of access: World Wide Web. System requirements: Adobe Reader. |
format |
Thesis |
author |
Ferrer, Tatiana. |
author_facet |
Ferrer, Tatiana. |
author_sort |
Ferrer, Tatiana. |
title |
Diversity and selection in the major histocompatibility complex [electronic resource] : DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus) / |
title_short |
Diversity and selection in the major histocompatibility complex [electronic resource] : DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus) / |
title_full |
Diversity and selection in the major histocompatibility complex [electronic resource] : DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus) / |
title_fullStr |
Diversity and selection in the major histocompatibility complex [electronic resource] : DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus) / |
title_full_unstemmed |
Diversity and selection in the major histocompatibility complex [electronic resource] : DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus) / |
title_sort |
diversity and selection in the major histocompatibility complex [electronic resource] : dqa and immune function in irl and atlantic bottlenose dolphins (tursiops truncatus) / |
publishDate |
2013 |
url |
http://digitool.fcla.edu:80/R/?func=dbin-jump-full&object_id=3362335 |
geographic |
Indian |
geographic_facet |
Indian |
genre |
Orca Orcinus orca |
genre_facet |
Orca Orcinus orca |
_version_ |
1766161462289498112 |