Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus)
Recently, there has been an increase in marine mammal mortalities, most commonly Atlantic bottlenose dolphins, Tursiops truncatus, which is an alarming indication of the health status of the marine ecosystem. Studies have demonstrated that some free-ranging dolphins exhibit a suppressed immune syste...
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ftfloridaatluniv:oai:fau.digital.flvc.org:fau_31264 2023-05-15T17:30:53+02:00 Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus) Bible, Brittany (author) Nouri-Shirazi, Mahyar (Thesis advisor) Florida Atlantic University (Degree grantor) Charles E. Schmidt College of Medicine Department of Biomedical Science 129 p. application/pdf http://purl.flvc.org/fau/fd/FA00004347 https://fau.digital.flvc.org/islandora/object/fau%3A31264/datastream/TN/view/Identifying%20and%20characterizing%20the%20immune%20cell%20populations%20of%20Atlantic%20bottlenose%20dolphins%20%28Tursiops%20truncatus%29.jpg English eng Florida Atlantic University Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. http://rightsstatements.org/vocab/InC/1.0/ Bottlenose dolphin -- Physiology Dolphins -- Physiology Marine animals -- North Atlantic Ocean -- Identification Marine mammals -- Atlantic Coast (U.S.) Marine mammals -- Effect of water pollution on Marine mammals -- North Atlantic Ocean -- Identification Electronic Thesis or Dissertation Text ftfloridaatluniv 2023-01-04T08:38:28Z Recently, there has been an increase in marine mammal mortalities, most commonly Atlantic bottlenose dolphins, Tursiops truncatus, which is an alarming indication of the health status of the marine ecosystem. Studies have demonstrated that some free-ranging dolphins exhibit a suppressed immune system possibly because of exposure to contaminants or infectious microorganisms. However, this research has been limited due to a lack of commercially available marine-specific antibodies. Therefore, the first chapter of this thesis aims to identify cross-reactive terrestrial-specific antibodies that could be used to phenotype and compare the immune cell populations of dolphins under human care and free-ranging dolphins. The second chapter aims to utilize terrestrial-specific growth factors and dendritic cell (DC) surface markers to generate, characterize, and compare ex vivo DCs from peripheral blood mononuclear cells (PBMCs) of dolphins under human care and free-ranging dolphins. In summary, I have identified differences within the PBMCs and ex vivo generated DCs of dolphins under human care and free-ranging dolphins that could potentially shed light on the impact of environmental contaminants and infectious microorganisms on immune cells which could lead to increased morbidity and mortality. Includes bibliography. Dissertation (Ph.D.)--Florida Atlantic University, 2015. FAU Electronic Theses and Dissertations Collection Thesis North Atlantic FAU Digital Collections (Florida Atlantic University Digital Library) |
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Open Polar |
collection |
FAU Digital Collections (Florida Atlantic University Digital Library) |
op_collection_id |
ftfloridaatluniv |
language |
English |
topic |
Bottlenose dolphin -- Physiology Dolphins -- Physiology Marine animals -- North Atlantic Ocean -- Identification Marine mammals -- Atlantic Coast (U.S.) Marine mammals -- Effect of water pollution on Marine mammals -- North Atlantic Ocean -- Identification |
spellingShingle |
Bottlenose dolphin -- Physiology Dolphins -- Physiology Marine animals -- North Atlantic Ocean -- Identification Marine mammals -- Atlantic Coast (U.S.) Marine mammals -- Effect of water pollution on Marine mammals -- North Atlantic Ocean -- Identification Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus) |
topic_facet |
Bottlenose dolphin -- Physiology Dolphins -- Physiology Marine animals -- North Atlantic Ocean -- Identification Marine mammals -- Atlantic Coast (U.S.) Marine mammals -- Effect of water pollution on Marine mammals -- North Atlantic Ocean -- Identification |
description |
Recently, there has been an increase in marine mammal mortalities, most commonly Atlantic bottlenose dolphins, Tursiops truncatus, which is an alarming indication of the health status of the marine ecosystem. Studies have demonstrated that some free-ranging dolphins exhibit a suppressed immune system possibly because of exposure to contaminants or infectious microorganisms. However, this research has been limited due to a lack of commercially available marine-specific antibodies. Therefore, the first chapter of this thesis aims to identify cross-reactive terrestrial-specific antibodies that could be used to phenotype and compare the immune cell populations of dolphins under human care and free-ranging dolphins. The second chapter aims to utilize terrestrial-specific growth factors and dendritic cell (DC) surface markers to generate, characterize, and compare ex vivo DCs from peripheral blood mononuclear cells (PBMCs) of dolphins under human care and free-ranging dolphins. In summary, I have identified differences within the PBMCs and ex vivo generated DCs of dolphins under human care and free-ranging dolphins that could potentially shed light on the impact of environmental contaminants and infectious microorganisms on immune cells which could lead to increased morbidity and mortality. Includes bibliography. Dissertation (Ph.D.)--Florida Atlantic University, 2015. FAU Electronic Theses and Dissertations Collection |
author2 |
Bible, Brittany (author) Nouri-Shirazi, Mahyar (Thesis advisor) Florida Atlantic University (Degree grantor) Charles E. Schmidt College of Medicine Department of Biomedical Science |
format |
Thesis |
title |
Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus) |
title_short |
Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus) |
title_full |
Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus) |
title_fullStr |
Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus) |
title_full_unstemmed |
Identifying and characterizing the immune cell populations of Atlantic bottlenose dolphins (Tursiops truncatus) |
title_sort |
identifying and characterizing the immune cell populations of atlantic bottlenose dolphins (tursiops truncatus) |
publisher |
Florida Atlantic University |
url |
http://purl.flvc.org/fau/fd/FA00004347 https://fau.digital.flvc.org/islandora/object/fau%3A31264/datastream/TN/view/Identifying%20and%20characterizing%20the%20immune%20cell%20populations%20of%20Atlantic%20bottlenose%20dolphins%20%28Tursiops%20truncatus%29.jpg |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_rights |
Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. http://rightsstatements.org/vocab/InC/1.0/ |
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