Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men
Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men.A...
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ftenea:oai:iris.enea.it:20.500.12079/412 2024-03-31T07:53:38+00:00 Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men Spanò, M. Spanò, M. 2013 https://hdl.handle.net/20.500.12079/412 https://doi.org/10.1016/j.mce.2013.03.005 http://www.scopus.com/inward/record.url?eid=2-s2.0-84876379966&partnerID=40&md5=1a9a1dc7aa2562b1ee67dfd6bb52c436 en eng volume:370 issue:1-2 numberofpages:163 - 171 journal:MOLECULAR AND CELLULAR ENDOCRINOLOGY http://hdl.handle.net/20.500.12079/412 doi:10.1016/j.mce.2013.03.005 info:eu-repo/semantics/altIdentifier/scopus/Scopus ID: 2-s2.0-84876379966 http://www.scopus.com/inward/record.url?eid=2-s2.0-84876379966&partnerID=40&md5=1a9a1dc7aa2562b1ee67dfd6bb52c436 Genetic-association studie Trinucleotide repeat Cross-sectional studie Reproduction Accessory sex organs info:eu-repo/semantics/article 2013 ftenea https://doi.org/20.500.12079/41210.1016/j.mce.2013.03.005 2024-03-06T00:12:05Z Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men.A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas-positive sperm, while men with longer GGN had higher oestradiol levels.These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear. © 2013 Elsevier Ireland Ltd. Article in Journal/Newspaper inuit ENEA-IRIS Open Archive (Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile) Molecular and Cellular Endocrinology 370 1-2 163 171 |
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ENEA-IRIS Open Archive (Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile) |
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ftenea |
language |
English |
topic |
Genetic-association studie Trinucleotide repeat Cross-sectional studie Reproduction Accessory sex organs |
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Genetic-association studie Trinucleotide repeat Cross-sectional studie Reproduction Accessory sex organs Spanò, M. Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
topic_facet |
Genetic-association studie Trinucleotide repeat Cross-sectional studie Reproduction Accessory sex organs |
description |
Recently the dogma that there is an inverse linear association between androgen receptor (AR) CAG and GGN polymorphisms and receptor activity has been challenged. We analysed the pattern of association between 21 male reproductive phenotypes and AR CAG/GGN repeat lengths in 557 proven-fertile men.A linear association was only found between sperm DNA fragmentation index (DFI) and CAG length, and between inhibin B and GGN length. Men with longer CAG then the reference (22-24), had higher oestradiol levels, whereas men with shorter CAG stretches had a higher DFI and a higher proportion of Fas-positive germ cells. Subjects with either short or long CAG had increased seminal levels of prostate-specific antigen and neutral α-glucosidase activity. Compared to men with the median GGN length of 23, those with shorter GGN repeats had higher levels of inhibin B, higher proportions of normal and progressive sperm, and a higher fraction of Fas-positive sperm, while men with longer GGN had higher oestradiol levels.These data indicate that at least for some markers of male reproductive function the association with CAG or GGN repeat length is curvilinear. © 2013 Elsevier Ireland Ltd. |
author2 |
Spanò, M. |
format |
Article in Journal/Newspaper |
author |
Spanò, M. |
author_facet |
Spanò, M. |
author_sort |
Spanò, M. |
title |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_short |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_full |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_fullStr |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_full_unstemmed |
Non-linear association between androgen receptor CAG and GGN repeat lengths and reproductive parameters in fertile European and Inuit men |
title_sort |
non-linear association between androgen receptor cag and ggn repeat lengths and reproductive parameters in fertile european and inuit men |
publishDate |
2013 |
url |
https://hdl.handle.net/20.500.12079/412 https://doi.org/10.1016/j.mce.2013.03.005 http://www.scopus.com/inward/record.url?eid=2-s2.0-84876379966&partnerID=40&md5=1a9a1dc7aa2562b1ee67dfd6bb52c436 |
genre |
inuit |
genre_facet |
inuit |
op_relation |
volume:370 issue:1-2 numberofpages:163 - 171 journal:MOLECULAR AND CELLULAR ENDOCRINOLOGY http://hdl.handle.net/20.500.12079/412 doi:10.1016/j.mce.2013.03.005 info:eu-repo/semantics/altIdentifier/scopus/Scopus ID: 2-s2.0-84876379966 http://www.scopus.com/inward/record.url?eid=2-s2.0-84876379966&partnerID=40&md5=1a9a1dc7aa2562b1ee67dfd6bb52c436 |
op_doi |
https://doi.org/20.500.12079/41210.1016/j.mce.2013.03.005 |
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Molecular and Cellular Endocrinology |
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370 |
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1-2 |
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