Learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid
Introduction: In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ–CNs. Methods: Aβ– CNs(n= 333) und...
Published in: | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring |
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Edith Cowan University, Research Online, Perth, Western Australia
2021
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ftedithcowan:oai:ro.ecu.edu.au:ecuworkspost2013-11425 2023-05-15T17:53:25+02:00 Learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid Lim, Yen Ying Baker, Jenalle E. Mills, Andrea Bruns, Loren Fowler, Christopher Fripp, Jurgen Rainey-Smith, Stephanie R. Ames, David Masters, Colin L. Maruff, Paul 2021-01-01T08:00:00Z application/pdf https://ro.ecu.edu.au/ecuworkspost2013/10419 https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=11425&context=ecuworkspost2013 unknown Edith Cowan University, Research Online, Perth, Western Australia https://ro.ecu.edu.au/ecuworkspost2013/10419 https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=11425&context=ecuworkspost2013 http://creativecommons.org/licenses/by-nc-nd/4.0/ CC-BY-NC-ND Research outputs 2014 to 2021 Alzheimer’s disease Amyloid Apolipoprotein E Learning Memory Medicine and Health Sciences text 2021 ftedithcowan 2022-02-26T23:50:26Z Introduction: In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ–CNs. Methods: Aβ– CNs(n= 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT) over 6 days. Results: Aβ– ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non-carriers (d = 0.3). Rates of learning on the ORCA-LLT were significantly slower in Aβ– ε4 carriers compared to non-carriers (d = 1.2). Discussion: In Aβ– CNs,ε4 is associated with a reduced ability to benefit from experience. This manifested as reduced practice effects (small to moderate in magnitude) over 108 months on the episodic memory composite, and a learning deficit (large in magnitude) over 6 days on the ORCA-LLT. Alzheimer’s disease (AD)–related cognitive abnormalities can manifest before preclinical AD thresholds. Text Orca Edith Cowan University (ECU, Australia): Research Online Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 13 1 |
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Edith Cowan University (ECU, Australia): Research Online |
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ftedithcowan |
language |
unknown |
topic |
Alzheimer’s disease Amyloid Apolipoprotein E Learning Memory Medicine and Health Sciences |
spellingShingle |
Alzheimer’s disease Amyloid Apolipoprotein E Learning Memory Medicine and Health Sciences Lim, Yen Ying Baker, Jenalle E. Mills, Andrea Bruns, Loren Fowler, Christopher Fripp, Jurgen Rainey-Smith, Stephanie R. Ames, David Masters, Colin L. Maruff, Paul Learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid |
topic_facet |
Alzheimer’s disease Amyloid Apolipoprotein E Learning Memory Medicine and Health Sciences |
description |
Introduction: In cognitively normal (CN) adults, increased rates of amyloid beta (Aβ) accumulation can be detected in low Aβ (Aβ–) apolipoprotein E (APOE) ε4 carriers. We aimed to determine the effect of ε4 on the ability to benefit from experience (ie, learn) in Aβ–CNs. Methods: Aβ– CNs(n= 333) underwent episodic memory assessments every 18 months for 108 months. A subset (n = 48) completed the Online Repeatable Cognitive Assessment-Language Learning Test (ORCA-LLT) over 6 days. Results: Aβ– ε4 carriers showed significantly lower rates of improvement on episodic memory over 108 months compared to non-carriers (d = 0.3). Rates of learning on the ORCA-LLT were significantly slower in Aβ– ε4 carriers compared to non-carriers (d = 1.2). Discussion: In Aβ– CNs,ε4 is associated with a reduced ability to benefit from experience. This manifested as reduced practice effects (small to moderate in magnitude) over 108 months on the episodic memory composite, and a learning deficit (large in magnitude) over 6 days on the ORCA-LLT. Alzheimer’s disease (AD)–related cognitive abnormalities can manifest before preclinical AD thresholds. |
format |
Text |
author |
Lim, Yen Ying Baker, Jenalle E. Mills, Andrea Bruns, Loren Fowler, Christopher Fripp, Jurgen Rainey-Smith, Stephanie R. Ames, David Masters, Colin L. Maruff, Paul |
author_facet |
Lim, Yen Ying Baker, Jenalle E. Mills, Andrea Bruns, Loren Fowler, Christopher Fripp, Jurgen Rainey-Smith, Stephanie R. Ames, David Masters, Colin L. Maruff, Paul |
author_sort |
Lim, Yen Ying |
title |
Learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid |
title_short |
Learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid |
title_full |
Learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid |
title_fullStr |
Learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid |
title_full_unstemmed |
Learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid |
title_sort |
learning deficit in cognitively normal apoe ε4 carriers with low β-amyloid |
publisher |
Edith Cowan University, Research Online, Perth, Western Australia |
publishDate |
2021 |
url |
https://ro.ecu.edu.au/ecuworkspost2013/10419 https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=11425&context=ecuworkspost2013 |
genre |
Orca |
genre_facet |
Orca |
op_source |
Research outputs 2014 to 2021 |
op_relation |
https://ro.ecu.edu.au/ecuworkspost2013/10419 https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=11425&context=ecuworkspost2013 |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
op_rightsnorm |
CC-BY-NC-ND |
container_title |
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring |
container_volume |
13 |
container_issue |
1 |
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1766161123991617536 |