The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression
International audience Mitochondria play a fundamental role in cellular metabolism, being responsible for most of the energy production of the cell in the oxidative phosphorylation (OXPHOS) pathway. Mitochondrial DNA (mtDNA) encodes for key components of this process, but its direct role in adaptati...
Published in: | Genome Biology and Evolution |
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Main Authors: | , , , , , |
Other Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2014
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Subjects: | |
Online Access: | https://hal.umontpellier.fr/hal-02347339 https://hal.umontpellier.fr/hal-02347339/document https://hal.umontpellier.fr/hal-02347339/file/evu059.pdf https://doi.org/10.1093/gbe/evu059 |
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Open Polar |
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EPHE (Ecole pratique des hautes études, Paris): HAL |
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ftecolephe |
language |
English |
topic |
This project has been deposited at GenBank under the accessions KJ397605 KJ397606 KJ397607 KJ397608 KJ397609 KJ397610 KJ397611 KJ397612 KJ397613 and KJ397614 mitogenomics Lepus codon evolution d N /d S protein structure positive selection [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] |
spellingShingle |
This project has been deposited at GenBank under the accessions KJ397605 KJ397606 KJ397607 KJ397608 KJ397609 KJ397610 KJ397611 KJ397612 KJ397613 and KJ397614 mitogenomics Lepus codon evolution d N /d S protein structure positive selection [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] Melo-Ferreira, José Vilela, Joana Fonseca, Miguel da Fonseca, Rute, R Boursot, Pierre Alves, Paulo, C. The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression |
topic_facet |
This project has been deposited at GenBank under the accessions KJ397605 KJ397606 KJ397607 KJ397608 KJ397609 KJ397610 KJ397611 KJ397612 KJ397613 and KJ397614 mitogenomics Lepus codon evolution d N /d S protein structure positive selection [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] |
description |
International audience Mitochondria play a fundamental role in cellular metabolism, being responsible for most of the energy production of the cell in the oxidative phosphorylation (OXPHOS) pathway. Mitochondrial DNA (mtDNA) encodes for key components of this process, but its direct role in adaptation remains far from understood. Hares (Lepus spp.) are privileged models to study the impact of natural selection on mitogenomic evolution because 1) species are adapted to contrasting environments, including arctic, with different metabolic pressures, and 2) mtDNA introgression from arctic into temperate species is widespread. Here, we analyzed the sequences of 11 complete mitogenomes (ten newly obtained) of hares of temperate and arctic origins (including two of arctic origin introgressed into temperate species). The analysis of patterns of codon substitutions along the reconstructed phylogeny showed evidence for positive selection in several codons in genes of the OXPHOS complexes, most notably affecting the arctic lineage. However, using theoretical models, no predictable effect of these differences was found on the structure and physicochemical properties of the encoded proteins, suggesting that the focus of selection may lie on complex interactions with nuclear encoded peptides. Also, a cloverleaf structure was detected in the control region only from the arctic mtDNA lineage, which may influence mtDNA replication and transcription. These results suggest that adaptation impacted the evolution of hare mtDNA and may have influenced the occurrence and consequences of the many reported cases of massive mtDNA introgression. However, the origin of adaptation remains elusive. |
author2 |
Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO-UP) Universidade do Porto = University of Porto-CESPU Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO) Centro de Investigacão em Biodiversidade e Recursos Genéticos (CIBIO) Universidade do Porto = University of Porto Faculdade de Ciências da Universidade do Porto (FCUP) Universidade de Vigo Institut des Sciences de l'Evolution de Montpellier (UMR ISEM) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE) Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
Melo-Ferreira, José Vilela, Joana Fonseca, Miguel da Fonseca, Rute, R Boursot, Pierre Alves, Paulo, C. |
author_facet |
Melo-Ferreira, José Vilela, Joana Fonseca, Miguel da Fonseca, Rute, R Boursot, Pierre Alves, Paulo, C. |
author_sort |
Melo-Ferreira, José |
title |
The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression |
title_short |
The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression |
title_full |
The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression |
title_fullStr |
The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression |
title_full_unstemmed |
The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression |
title_sort |
elusive nature of adaptive mitochondrial dna evolution of an arctic lineage prone to frequent introgression |
publisher |
HAL CCSD |
publishDate |
2014 |
url |
https://hal.umontpellier.fr/hal-02347339 https://hal.umontpellier.fr/hal-02347339/document https://hal.umontpellier.fr/hal-02347339/file/evu059.pdf https://doi.org/10.1093/gbe/evu059 |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
ISSN: 1759-6653 EISSN: 1759-6653 Genome Biology and Evolution https://hal.umontpellier.fr/hal-02347339 Genome Biology and Evolution, 2014, 6 (4), pp.886-896. ⟨10.1093/gbe/evu059⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1093/gbe/evu059 hal-02347339 https://hal.umontpellier.fr/hal-02347339 https://hal.umontpellier.fr/hal-02347339/document https://hal.umontpellier.fr/hal-02347339/file/evu059.pdf doi:10.1093/gbe/evu059 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1093/gbe/evu059 |
container_title |
Genome Biology and Evolution |
container_volume |
6 |
container_issue |
4 |
container_start_page |
886 |
op_container_end_page |
896 |
_version_ |
1799472693438840832 |
spelling |
ftecolephe:oai:HAL:hal-02347339v1 2024-05-19T07:34:35+00:00 The Elusive Nature of Adaptive Mitochondrial DNA Evolution of an Arctic Lineage Prone to Frequent Introgression Melo-Ferreira, José Vilela, Joana Fonseca, Miguel da Fonseca, Rute, R Boursot, Pierre Alves, Paulo, C. Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO-UP) Universidade do Porto = University of Porto-CESPU Centro de Investigação em Biodiversidade e Recursos Genéticos (CIBIO) Centro de Investigacão em Biodiversidade e Recursos Genéticos (CIBIO) Universidade do Porto = University of Porto Faculdade de Ciências da Universidade do Porto (FCUP) Universidade de Vigo Institut des Sciences de l'Evolution de Montpellier (UMR ISEM) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE) Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS) 2014-04-01 https://hal.umontpellier.fr/hal-02347339 https://hal.umontpellier.fr/hal-02347339/document https://hal.umontpellier.fr/hal-02347339/file/evu059.pdf https://doi.org/10.1093/gbe/evu059 en eng HAL CCSD Society for Molecular Biology and Evolution info:eu-repo/semantics/altIdentifier/doi/10.1093/gbe/evu059 hal-02347339 https://hal.umontpellier.fr/hal-02347339 https://hal.umontpellier.fr/hal-02347339/document https://hal.umontpellier.fr/hal-02347339/file/evu059.pdf doi:10.1093/gbe/evu059 info:eu-repo/semantics/OpenAccess ISSN: 1759-6653 EISSN: 1759-6653 Genome Biology and Evolution https://hal.umontpellier.fr/hal-02347339 Genome Biology and Evolution, 2014, 6 (4), pp.886-896. ⟨10.1093/gbe/evu059⟩ This project has been deposited at GenBank under the accessions KJ397605 KJ397606 KJ397607 KJ397608 KJ397609 KJ397610 KJ397611 KJ397612 KJ397613 and KJ397614 mitogenomics Lepus codon evolution d N /d S protein structure positive selection [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] info:eu-repo/semantics/article Journal articles 2014 ftecolephe https://doi.org/10.1093/gbe/evu059 2024-05-02T00:20:10Z International audience Mitochondria play a fundamental role in cellular metabolism, being responsible for most of the energy production of the cell in the oxidative phosphorylation (OXPHOS) pathway. Mitochondrial DNA (mtDNA) encodes for key components of this process, but its direct role in adaptation remains far from understood. Hares (Lepus spp.) are privileged models to study the impact of natural selection on mitogenomic evolution because 1) species are adapted to contrasting environments, including arctic, with different metabolic pressures, and 2) mtDNA introgression from arctic into temperate species is widespread. Here, we analyzed the sequences of 11 complete mitogenomes (ten newly obtained) of hares of temperate and arctic origins (including two of arctic origin introgressed into temperate species). The analysis of patterns of codon substitutions along the reconstructed phylogeny showed evidence for positive selection in several codons in genes of the OXPHOS complexes, most notably affecting the arctic lineage. However, using theoretical models, no predictable effect of these differences was found on the structure and physicochemical properties of the encoded proteins, suggesting that the focus of selection may lie on complex interactions with nuclear encoded peptides. Also, a cloverleaf structure was detected in the control region only from the arctic mtDNA lineage, which may influence mtDNA replication and transcription. These results suggest that adaptation impacted the evolution of hare mtDNA and may have influenced the occurrence and consequences of the many reported cases of massive mtDNA introgression. However, the origin of adaptation remains elusive. Article in Journal/Newspaper Arctic EPHE (Ecole pratique des hautes études, Paris): HAL Genome Biology and Evolution 6 4 886 896 |