Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit
ObjectiveTo evaluate subclinical atherosclerosis in Nunavik Inuit and its correlation to traditional cardiovascular disease risk factor.MethodThe intima–media thickness (IMT) of 12 segments of the carotid arteries (IMT12_seg) free of plaque were assessed in randomly selected 40 years old and older I...
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ftecolehesp:oai:HAL:hal-04265259v1 2024-02-11T10:05:18+01:00 Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit Noël, Martin Dewailly, Eric Chateau-Degat, Marie-Ludivine Counil, Emilie Anassour-Laouan-Sidi, Elhadji Lonn, Eva Université Laval Québec (ULaval) École des Hautes Études en Santé Publique EHESP (EHESP) 2012-01-01 https://hal.science/hal-04265259 https://doi.org/10.1016/j.atherosclerosis.2012.01.012 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2012.01.012 hal-04265259 https://hal.science/hal-04265259 doi:10.1016/j.atherosclerosis.2012.01.012 ISSN: 0021-9150 Atherosclerosis https://hal.science/hal-04265259 Atherosclerosis, 2012, 221 (2), pp.558-564. ⟨10.1016/j.atherosclerosis.2012.01.012⟩ https://www.sciencedirect.com/science/article/abs/pii/S0021915012000457 atherosclerosis cardiovascular diseases risk factor Inuit Canada [SHS]Humanities and Social Sciences [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie info:eu-repo/semantics/article Journal articles 2012 ftecolehesp https://doi.org/10.1016/j.atherosclerosis.2012.01.012 2024-01-17T17:20:59Z ObjectiveTo evaluate subclinical atherosclerosis in Nunavik Inuit and its correlation to traditional cardiovascular disease risk factor.MethodThe intima–media thickness (IMT) of 12 segments of the carotid arteries (IMT12_seg) free of plaque were assessed in randomly selected 40 years old and older Inuit from. Clinical assessment was performed which included fasting plasma glucose, fasting insulin, systemic blood pressure, body mass index, smoking, circulating blood lipids and oral glucose tolerance test. In addition, documented presence of ischemic heart disease (IHD), stroke, diabetes mellitus, hypertension and dyslipidemia were determined from medical files.ResultsThe average age of the 287 participants was 51.2 ± 0.6 years (56.8% women). Mean IMT12_seg was 0.80 ± 0.17 mm (range: 0.55–1.47 mm). Compared with disease free Inuit, individuals with history of stroke showed greater carotid internal IMT (0.68 ± 0.01 mm vs. 0.96 ± 0.15 mm respectively; p < 0.005) but no difference was observed for IHD. Hypertensive and dyslipidemic Inuit had higher IMT12_seg compared to risk factor free individuals but no difference was observed in diabetics. None of the clinical assessments were associated with IMT12_seg. In a multivariate backward elimination model, only age, gender, and medically documented history of hypertension were found to be predictors of IMT12_seg (adjusted r-square of 0.54; p < 0.0001).ConclusionCompared with disease free Nunavik Inuit, subclinical signs of atherosclerosis determined by IMT was higher in individual diagnosed with stroke. Independent predictors of IMT12_seg in our group were age, gender and history of hypertension. No other traditional risk factors imparted IMT. Article in Journal/Newspaper inuit Nunavik EHESP - Productions scientifiques de l'Ecole des hautes études en santé publique Canada Nunavik Atherosclerosis 221 2 558 564 |
institution |
Open Polar |
collection |
EHESP - Productions scientifiques de l'Ecole des hautes études en santé publique |
op_collection_id |
ftecolehesp |
language |
English |
topic |
atherosclerosis cardiovascular diseases risk factor Inuit Canada [SHS]Humanities and Social Sciences [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
spellingShingle |
atherosclerosis cardiovascular diseases risk factor Inuit Canada [SHS]Humanities and Social Sciences [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Noël, Martin Dewailly, Eric Chateau-Degat, Marie-Ludivine Counil, Emilie Anassour-Laouan-Sidi, Elhadji Lonn, Eva Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit |
topic_facet |
atherosclerosis cardiovascular diseases risk factor Inuit Canada [SHS]Humanities and Social Sciences [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
description |
ObjectiveTo evaluate subclinical atherosclerosis in Nunavik Inuit and its correlation to traditional cardiovascular disease risk factor.MethodThe intima–media thickness (IMT) of 12 segments of the carotid arteries (IMT12_seg) free of plaque were assessed in randomly selected 40 years old and older Inuit from. Clinical assessment was performed which included fasting plasma glucose, fasting insulin, systemic blood pressure, body mass index, smoking, circulating blood lipids and oral glucose tolerance test. In addition, documented presence of ischemic heart disease (IHD), stroke, diabetes mellitus, hypertension and dyslipidemia were determined from medical files.ResultsThe average age of the 287 participants was 51.2 ± 0.6 years (56.8% women). Mean IMT12_seg was 0.80 ± 0.17 mm (range: 0.55–1.47 mm). Compared with disease free Inuit, individuals with history of stroke showed greater carotid internal IMT (0.68 ± 0.01 mm vs. 0.96 ± 0.15 mm respectively; p < 0.005) but no difference was observed for IHD. Hypertensive and dyslipidemic Inuit had higher IMT12_seg compared to risk factor free individuals but no difference was observed in diabetics. None of the clinical assessments were associated with IMT12_seg. In a multivariate backward elimination model, only age, gender, and medically documented history of hypertension were found to be predictors of IMT12_seg (adjusted r-square of 0.54; p < 0.0001).ConclusionCompared with disease free Nunavik Inuit, subclinical signs of atherosclerosis determined by IMT was higher in individual diagnosed with stroke. Independent predictors of IMT12_seg in our group were age, gender and history of hypertension. No other traditional risk factors imparted IMT. |
author2 |
Université Laval Québec (ULaval) École des Hautes Études en Santé Publique EHESP (EHESP) |
format |
Article in Journal/Newspaper |
author |
Noël, Martin Dewailly, Eric Chateau-Degat, Marie-Ludivine Counil, Emilie Anassour-Laouan-Sidi, Elhadji Lonn, Eva |
author_facet |
Noël, Martin Dewailly, Eric Chateau-Degat, Marie-Ludivine Counil, Emilie Anassour-Laouan-Sidi, Elhadji Lonn, Eva |
author_sort |
Noël, Martin |
title |
Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit |
title_short |
Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit |
title_full |
Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit |
title_fullStr |
Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit |
title_full_unstemmed |
Cardiovascular risk factors and subclinical atherosclerosis among Nunavik Inuit |
title_sort |
cardiovascular risk factors and subclinical atherosclerosis among nunavik inuit |
publisher |
HAL CCSD |
publishDate |
2012 |
url |
https://hal.science/hal-04265259 https://doi.org/10.1016/j.atherosclerosis.2012.01.012 |
geographic |
Canada Nunavik |
geographic_facet |
Canada Nunavik |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_source |
ISSN: 0021-9150 Atherosclerosis https://hal.science/hal-04265259 Atherosclerosis, 2012, 221 (2), pp.558-564. ⟨10.1016/j.atherosclerosis.2012.01.012⟩ https://www.sciencedirect.com/science/article/abs/pii/S0021915012000457 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2012.01.012 hal-04265259 https://hal.science/hal-04265259 doi:10.1016/j.atherosclerosis.2012.01.012 |
op_doi |
https://doi.org/10.1016/j.atherosclerosis.2012.01.012 |
container_title |
Atherosclerosis |
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221 |
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2 |
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558 |
op_container_end_page |
564 |
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1790602243085434880 |