The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study.
To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets.Bi-directional Mendelian randomisation study.Genome-wide association studies from three Finnish cohorts (Northern...
Published in: | BMJ Medicine |
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Language: | English |
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2023
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ftdznevdb:oai:pub.dzne.de:257312 2023-11-05T03:44:19+01:00 The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. Karhunen, Ville Gill, Dipender Wielscher, Matthias Auvinen, Juha Veijola, Juha Herzig, Karl-Heinz Timonen, Markku Keinänen-Kiukaanniemi, Sirkka Dichgans, Martin Salmi, Marko Jalkanen, Sirpa Lehtimäki, Terho Huang, Jian Salomaa, Veikko Raitakari, Olli Jones, Simon A Hovingh, G Kees Tsilidis, Konstantinos K Järvelin, Marjo-Riitta Dehghan, Abbas Bouras, Emmanouil Malik, Rainer Ponsford, Mark J Ahola-Olli, Ari Papadopoulou, Areti Palaniswamy, Saranya Sebert, Sylvain DE 2023 https://pub.dzne.de/record/257312 https://pub.dzne.de/search?p=id:%22DZNE-2023-00381%22 eng eng BMJ Publishing Group Ltd. info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjmed-2022-000157 info:eu-repo/semantics/altIdentifier/pmid/pmid:36936266 info:eu-repo/semantics/altIdentifier/issn/2754-0413 https://pub.dzne.de/record/257312 https://pub.dzne.de/search?p=id:%22DZNE-2023-00381%22 info:eu-repo/semantics/openAccess BMJ medicine 2(1), e000157 (2023). doi:10.1136/bmjmed-2022-000157 info:eu-repo/classification/ddc/610 Cardiology Epidemiology Genetics info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2023 ftdznevdb https://doi.org/10.1136/bmjmed-2022-000157 2023-10-08T22:18:35Z To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets.Bi-directional Mendelian randomisation study.Genome-wide association studies from three Finnish cohorts (Northern Finland Birth Cohort 1966, Young Finns Study, or FINRISK study), and genetic association summary statistics pooled from observational studies for expression quantitative trait loci and cardiometabolic traits.Data for 47 circulating cytokines in 13 365 individuals from genome-wide association studies, summary statistic data for up to 21 735 individuals on circulating cytokines, summary statistic gene expression data across 49 tissues in 838 individuals, and summary statistic data for up to 1 320 016 individuals on cardiometabolic traits.Relations between circulating cytokines and cardiovascular, anthropometric, lipid, or glycaemic traits (coronary artery disease, stroke, type 2 diabetes mellitus, body mass index, waist circumference, waist to hip ratio, systolic blood pressure, glycated haemoglobin, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, triglycerides, C reactive protein, glucose, fasting insulin, and lifetime smoking).Genetic instrumental variables that are biologically plausible for the circulating cytokines were generated. The effects of cardiometabolic risk factors on concentrations of circulating cytokines, circulating cytokines on other circulating cytokines, and circulating cytokines on cardiometabolic outcomes were investigated.Genetic evidence (mendelian randomisation P<0.0011) suggests that higher body mass index, waist circumference, smoking, higher concentrations of lipids, and systolic blood pressure increase circulating concentrations of several inflammatory cytokines and C reactive protein. Evidence for causal relations (mendelian randomisation P<0.0011) were noted between circulating cytokines, including a key role of vascular endothelial ... Article in Journal/Newspaper Northern Finland DZNEPUB (German Center for Neurodegenerative Diseases) BMJ Medicine 2 1 e000157 |
institution |
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DZNEPUB (German Center for Neurodegenerative Diseases) |
op_collection_id |
ftdznevdb |
language |
English |
topic |
info:eu-repo/classification/ddc/610 Cardiology Epidemiology Genetics |
spellingShingle |
info:eu-repo/classification/ddc/610 Cardiology Epidemiology Genetics Karhunen, Ville Gill, Dipender Wielscher, Matthias Auvinen, Juha Veijola, Juha Herzig, Karl-Heinz Timonen, Markku Keinänen-Kiukaanniemi, Sirkka Dichgans, Martin Salmi, Marko Jalkanen, Sirpa Lehtimäki, Terho Huang, Jian Salomaa, Veikko Raitakari, Olli Jones, Simon A Hovingh, G Kees Tsilidis, Konstantinos K Järvelin, Marjo-Riitta Dehghan, Abbas Bouras, Emmanouil Malik, Rainer Ponsford, Mark J Ahola-Olli, Ari Papadopoulou, Areti Palaniswamy, Saranya Sebert, Sylvain The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. |
topic_facet |
info:eu-repo/classification/ddc/610 Cardiology Epidemiology Genetics |
description |
To leverage large scale genetic association data to investigate the interplay between circulating cytokines and cardiometabolic traits, and thus identifying potential therapeutic targets.Bi-directional Mendelian randomisation study.Genome-wide association studies from three Finnish cohorts (Northern Finland Birth Cohort 1966, Young Finns Study, or FINRISK study), and genetic association summary statistics pooled from observational studies for expression quantitative trait loci and cardiometabolic traits.Data for 47 circulating cytokines in 13 365 individuals from genome-wide association studies, summary statistic data for up to 21 735 individuals on circulating cytokines, summary statistic gene expression data across 49 tissues in 838 individuals, and summary statistic data for up to 1 320 016 individuals on cardiometabolic traits.Relations between circulating cytokines and cardiovascular, anthropometric, lipid, or glycaemic traits (coronary artery disease, stroke, type 2 diabetes mellitus, body mass index, waist circumference, waist to hip ratio, systolic blood pressure, glycated haemoglobin, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, triglycerides, C reactive protein, glucose, fasting insulin, and lifetime smoking).Genetic instrumental variables that are biologically plausible for the circulating cytokines were generated. The effects of cardiometabolic risk factors on concentrations of circulating cytokines, circulating cytokines on other circulating cytokines, and circulating cytokines on cardiometabolic outcomes were investigated.Genetic evidence (mendelian randomisation P<0.0011) suggests that higher body mass index, waist circumference, smoking, higher concentrations of lipids, and systolic blood pressure increase circulating concentrations of several inflammatory cytokines and C reactive protein. Evidence for causal relations (mendelian randomisation P<0.0011) were noted between circulating cytokines, including a key role of vascular endothelial ... |
format |
Article in Journal/Newspaper |
author |
Karhunen, Ville Gill, Dipender Wielscher, Matthias Auvinen, Juha Veijola, Juha Herzig, Karl-Heinz Timonen, Markku Keinänen-Kiukaanniemi, Sirkka Dichgans, Martin Salmi, Marko Jalkanen, Sirpa Lehtimäki, Terho Huang, Jian Salomaa, Veikko Raitakari, Olli Jones, Simon A Hovingh, G Kees Tsilidis, Konstantinos K Järvelin, Marjo-Riitta Dehghan, Abbas Bouras, Emmanouil Malik, Rainer Ponsford, Mark J Ahola-Olli, Ari Papadopoulou, Areti Palaniswamy, Saranya Sebert, Sylvain |
author_facet |
Karhunen, Ville Gill, Dipender Wielscher, Matthias Auvinen, Juha Veijola, Juha Herzig, Karl-Heinz Timonen, Markku Keinänen-Kiukaanniemi, Sirkka Dichgans, Martin Salmi, Marko Jalkanen, Sirpa Lehtimäki, Terho Huang, Jian Salomaa, Veikko Raitakari, Olli Jones, Simon A Hovingh, G Kees Tsilidis, Konstantinos K Järvelin, Marjo-Riitta Dehghan, Abbas Bouras, Emmanouil Malik, Rainer Ponsford, Mark J Ahola-Olli, Ari Papadopoulou, Areti Palaniswamy, Saranya Sebert, Sylvain |
author_sort |
Karhunen, Ville |
title |
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. |
title_short |
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. |
title_full |
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. |
title_fullStr |
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. |
title_full_unstemmed |
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. |
title_sort |
interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. |
publisher |
BMJ Publishing Group Ltd. |
publishDate |
2023 |
url |
https://pub.dzne.de/record/257312 https://pub.dzne.de/search?p=id:%22DZNE-2023-00381%22 |
op_coverage |
DE |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
BMJ medicine 2(1), e000157 (2023). doi:10.1136/bmjmed-2022-000157 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjmed-2022-000157 info:eu-repo/semantics/altIdentifier/pmid/pmid:36936266 info:eu-repo/semantics/altIdentifier/issn/2754-0413 https://pub.dzne.de/record/257312 https://pub.dzne.de/search?p=id:%22DZNE-2023-00381%22 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1136/bmjmed-2022-000157 |
container_title |
BMJ Medicine |
container_volume |
2 |
container_issue |
1 |
container_start_page |
e000157 |
_version_ |
1781703847990788096 |