Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia.
Viliuisk encephalomyelitis (VE) is an endemic neurological disease in Northeast Siberia and generally considered to be a chronic encephalomyelitis of unknown origin actually spreading in the Sakha (Yakutian) Republic.In search for the pathophysiology and causative agent of VE, we performed a cross-s...
Published in: | PLoS ONE |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
PLOS
2014
|
Subjects: | |
Online Access: | https://pub.dzne.de/record/137300 https://pub.dzne.de/search?p=id:%22DZNE-2020-03622%22 |
id |
ftdznevdb:oai:pub.dzne.de:137300 |
---|---|
record_format |
openpolar |
spelling |
ftdznevdb:oai:pub.dzne.de:137300 2023-10-09T21:55:36+02:00 Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. Storch, Alexander Kassubek, Jan Tumani, Hayrettin Vladimirtsev, Vsevolod A Hermann, Andreas Osakovsky, Vladimir L Baranov, Vladimir A Krivoshapkin, Vadim G Ludolph, Albert C DE 2014 https://pub.dzne.de/record/137300 https://pub.dzne.de/search?p=id:%22DZNE-2020-03622%22 eng eng PLOS info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0084670 info:eu-repo/semantics/altIdentifier/issn/1932-6203 info:eu-repo/semantics/altIdentifier/pmid/pmid:24586232 https://pub.dzne.de/record/137300 https://pub.dzne.de/search?p=id:%22DZNE-2020-03622%22 info:eu-repo/semantics/openAccess PLOS ONE 9(2), e84670 (2014). doi:10.1371/journal.pone.0084670 info:eu-repo/classification/ddc/610 Adolescent Adult Aged Cross-Sectional Studies Electrophysiology Encephalomyelitis: physiopathology Female Humans Hydrocephalus: physiopathology Male Meningitis: physiopathology Middle Aged Siberia Young Adult info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2014 ftdznevdb https://doi.org/10.1371/journal.pone.0084670 2023-09-21T07:34:25Z Viliuisk encephalomyelitis (VE) is an endemic neurological disease in Northeast Siberia and generally considered to be a chronic encephalomyelitis of unknown origin actually spreading in the Sakha (Yakutian) Republic.In search for the pathophysiology and causative agent of VE, we performed a cross-sectional study on clinical, serological and neuroimaging data on chronic VE patients during two medical expeditions to three villages within the Viliuiski river basin in the Republic of Sakha in 2000 and to the capital Yakutsk in 2006. The severity of the core clinical picture with predominant sensory ataxia, gait apraxia, lower limb spasticity, cognitive impairment and bladder dysfunction correlated with the degree of MRI findings showing enlargement of inner ventricular spaces as in communicating hydrocephalus. Laboratory studies revealed transient eosinophilia during the preceding acute meningitis-like phase, but no ongoing inflammatory process in the CSF. We found immune reactions against Toxocara canis in the majority of chronic VE patients but rarely in controls (P = 0.025; Fisher's exact test). Histological analysis of subacute to subchronic VE brain samples showed eosinophilic infiltrations with no signs of persistent Toxocara canis infection.Our data showed that pressure by the communicating hydrocephalus as a mechanical factor is the major pathogenic mechanism in chronic VE, most likely triggered by eosinophilic meningitis. There are no signs for an ongoing inflammatory process in chronic VE. The past eosinophilic reaction in VE might be caused by Toxocara ssp. infection and might therefore represent the first hint for an initial cause leading to the development of chronic VE. Our data provide a framework for future studies and potential therapeutic interventions for this enigmatic epidemic neurological disease potentially spreading in Sakha Republic. Article in Journal/Newspaper Republic of Sakha Sakha Sakha Republic Yakutsk Siberia DZNEPUB (German Center for Neurodegenerative Diseases) Sakha Yakutsk PLoS ONE 9 2 e84670 |
institution |
Open Polar |
collection |
DZNEPUB (German Center for Neurodegenerative Diseases) |
op_collection_id |
ftdznevdb |
language |
English |
topic |
info:eu-repo/classification/ddc/610 Adolescent Adult Aged Cross-Sectional Studies Electrophysiology Encephalomyelitis: physiopathology Female Humans Hydrocephalus: physiopathology Male Meningitis: physiopathology Middle Aged Siberia Young Adult |
spellingShingle |
info:eu-repo/classification/ddc/610 Adolescent Adult Aged Cross-Sectional Studies Electrophysiology Encephalomyelitis: physiopathology Female Humans Hydrocephalus: physiopathology Male Meningitis: physiopathology Middle Aged Siberia Young Adult Storch, Alexander Kassubek, Jan Tumani, Hayrettin Vladimirtsev, Vsevolod A Hermann, Andreas Osakovsky, Vladimir L Baranov, Vladimir A Krivoshapkin, Vadim G Ludolph, Albert C Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. |
topic_facet |
info:eu-repo/classification/ddc/610 Adolescent Adult Aged Cross-Sectional Studies Electrophysiology Encephalomyelitis: physiopathology Female Humans Hydrocephalus: physiopathology Male Meningitis: physiopathology Middle Aged Siberia Young Adult |
description |
Viliuisk encephalomyelitis (VE) is an endemic neurological disease in Northeast Siberia and generally considered to be a chronic encephalomyelitis of unknown origin actually spreading in the Sakha (Yakutian) Republic.In search for the pathophysiology and causative agent of VE, we performed a cross-sectional study on clinical, serological and neuroimaging data on chronic VE patients during two medical expeditions to three villages within the Viliuiski river basin in the Republic of Sakha in 2000 and to the capital Yakutsk in 2006. The severity of the core clinical picture with predominant sensory ataxia, gait apraxia, lower limb spasticity, cognitive impairment and bladder dysfunction correlated with the degree of MRI findings showing enlargement of inner ventricular spaces as in communicating hydrocephalus. Laboratory studies revealed transient eosinophilia during the preceding acute meningitis-like phase, but no ongoing inflammatory process in the CSF. We found immune reactions against Toxocara canis in the majority of chronic VE patients but rarely in controls (P = 0.025; Fisher's exact test). Histological analysis of subacute to subchronic VE brain samples showed eosinophilic infiltrations with no signs of persistent Toxocara canis infection.Our data showed that pressure by the communicating hydrocephalus as a mechanical factor is the major pathogenic mechanism in chronic VE, most likely triggered by eosinophilic meningitis. There are no signs for an ongoing inflammatory process in chronic VE. The past eosinophilic reaction in VE might be caused by Toxocara ssp. infection and might therefore represent the first hint for an initial cause leading to the development of chronic VE. Our data provide a framework for future studies and potential therapeutic interventions for this enigmatic epidemic neurological disease potentially spreading in Sakha Republic. |
format |
Article in Journal/Newspaper |
author |
Storch, Alexander Kassubek, Jan Tumani, Hayrettin Vladimirtsev, Vsevolod A Hermann, Andreas Osakovsky, Vladimir L Baranov, Vladimir A Krivoshapkin, Vadim G Ludolph, Albert C |
author_facet |
Storch, Alexander Kassubek, Jan Tumani, Hayrettin Vladimirtsev, Vsevolod A Hermann, Andreas Osakovsky, Vladimir L Baranov, Vladimir A Krivoshapkin, Vadim G Ludolph, Albert C |
author_sort |
Storch, Alexander |
title |
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. |
title_short |
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. |
title_full |
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. |
title_fullStr |
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. |
title_full_unstemmed |
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. |
title_sort |
communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic viliuisk encephalomyelitis in northeastern siberia. |
publisher |
PLOS |
publishDate |
2014 |
url |
https://pub.dzne.de/record/137300 https://pub.dzne.de/search?p=id:%22DZNE-2020-03622%22 |
op_coverage |
DE |
geographic |
Sakha Yakutsk |
geographic_facet |
Sakha Yakutsk |
genre |
Republic of Sakha Sakha Sakha Republic Yakutsk Siberia |
genre_facet |
Republic of Sakha Sakha Sakha Republic Yakutsk Siberia |
op_source |
PLOS ONE 9(2), e84670 (2014). doi:10.1371/journal.pone.0084670 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0084670 info:eu-repo/semantics/altIdentifier/issn/1932-6203 info:eu-repo/semantics/altIdentifier/pmid/pmid:24586232 https://pub.dzne.de/record/137300 https://pub.dzne.de/search?p=id:%22DZNE-2020-03622%22 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0084670 |
container_title |
PLoS ONE |
container_volume |
9 |
container_issue |
2 |
container_start_page |
e84670 |
_version_ |
1779319580371451904 |