Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method
Yurekli, Aslan/0000-0003-2812-2133 WOS: 000473301300002 PubMed: 31233167 Introduction: The rabbit ear hypertrophic scar model is a preferred animal model of excessive scarring for investigating the scarring process and novel treatment modalities. In this model, surgical removal of perichondrium can...
Main Authors: | , , , , , |
---|---|
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Dermatovenerological Soc Slovenia
2019
|
Subjects: | |
Online Access: | https://hdl.handle.net/20.500.12684/5421 https://doi.org/10.15570/actaapa.2019.15 |
id |
ftduzceuniv:oai:acikerisim.duzce.edu.tr:20.500.12684/5421 |
---|---|
record_format |
openpolar |
spelling |
ftduzceuniv:oai:acikerisim.duzce.edu.tr:20.500.12684/5421 2023-05-15T18:15:16+02:00 Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method Tunca, Mustafa Gamsızkan, Mehmet Yürekli, Aslan Göksel, Berk Alp Çiçek, Ali Fuat Çalışkan, Ercan DÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü 2019 https://hdl.handle.net/20.500.12684/5421 https://doi.org/10.15570/actaapa.2019.15 eng eng Dermatovenerological Soc Slovenia 10.15570/actaapa.2019.15 Acta Dermatovenerologica Alpina Pannonica Et Adriatica Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı 1318-4458 1581-2979 https://doi.org/10.15570/actaapa.2019.15 https://hdl.handle.net/20.500.12684/5421 28 2 57 59 info:eu-repo/semantics/openAccess animal model cryotherapy hypertrophic scar article 2019 ftduzceuniv https://doi.org/20.500.12684/5421 https://doi.org/10.15570/actaapa.2019.15 2021-08-05T10:33:33Z Yurekli, Aslan/0000-0003-2812-2133 WOS: 000473301300002 PubMed: 31233167 Introduction: The rabbit ear hypertrophic scar model is a preferred animal model of excessive scarring for investigating the scarring process and novel treatment modalities. In this model, surgical removal of perichondrium can be challenging, and it is often insufficient or damages the underlying cartilage. It is hypothesized that cryosurgery would offer a more efficient alternative to conventional surgery. The objective of this study was to compare structural changes in scar tissues in two groups of the hypertrophic scar model: cryosurgery compared to standard conventional surgery. Methods: We introduced a novel technique to remove perichondrium using cryosurgery. Hypertrophic scars obtained with conventional surgery and cryosurgery were studied in a left-right comparison method. Comparative parameters included the histological structure of the scars and structural changes in the cartilage just beneath the scarring. Results: Cryosurgery produced similar scars in comparison to conventional surgery. Although statistically not significant (p = 0.16), the histological findings of cartilage damage were lower in the cryosurgery group (six out of 21) compared to the established model (10 out of 20). Conclusions: This study suggests that cryotherapy can be used for removal of perichondrium. Gulhane School of Medicine Research Grant committee This study was financially supported by the Gulhane School of Medicine Research Grant committee and was conducted at the Animal Research Laboratory of the same institution. Article in Journal/Newspaper SCAR Düzce University Institutional Repository (DSpace@Düzce) |
institution |
Open Polar |
collection |
Düzce University Institutional Repository (DSpace@Düzce) |
op_collection_id |
ftduzceuniv |
language |
English |
topic |
animal model cryotherapy hypertrophic scar |
spellingShingle |
animal model cryotherapy hypertrophic scar Tunca, Mustafa Gamsızkan, Mehmet Yürekli, Aslan Göksel, Berk Alp Çiçek, Ali Fuat Çalışkan, Ercan Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method |
topic_facet |
animal model cryotherapy hypertrophic scar |
description |
Yurekli, Aslan/0000-0003-2812-2133 WOS: 000473301300002 PubMed: 31233167 Introduction: The rabbit ear hypertrophic scar model is a preferred animal model of excessive scarring for investigating the scarring process and novel treatment modalities. In this model, surgical removal of perichondrium can be challenging, and it is often insufficient or damages the underlying cartilage. It is hypothesized that cryosurgery would offer a more efficient alternative to conventional surgery. The objective of this study was to compare structural changes in scar tissues in two groups of the hypertrophic scar model: cryosurgery compared to standard conventional surgery. Methods: We introduced a novel technique to remove perichondrium using cryosurgery. Hypertrophic scars obtained with conventional surgery and cryosurgery were studied in a left-right comparison method. Comparative parameters included the histological structure of the scars and structural changes in the cartilage just beneath the scarring. Results: Cryosurgery produced similar scars in comparison to conventional surgery. Although statistically not significant (p = 0.16), the histological findings of cartilage damage were lower in the cryosurgery group (six out of 21) compared to the established model (10 out of 20). Conclusions: This study suggests that cryotherapy can be used for removal of perichondrium. Gulhane School of Medicine Research Grant committee This study was financially supported by the Gulhane School of Medicine Research Grant committee and was conducted at the Animal Research Laboratory of the same institution. |
author2 |
DÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü |
format |
Article in Journal/Newspaper |
author |
Tunca, Mustafa Gamsızkan, Mehmet Yürekli, Aslan Göksel, Berk Alp Çiçek, Ali Fuat Çalışkan, Ercan |
author_facet |
Tunca, Mustafa Gamsızkan, Mehmet Yürekli, Aslan Göksel, Berk Alp Çiçek, Ali Fuat Çalışkan, Ercan |
author_sort |
Tunca, Mustafa |
title |
Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method |
title_short |
Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method |
title_full |
Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method |
title_fullStr |
Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method |
title_full_unstemmed |
Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method |
title_sort |
cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method |
publisher |
Dermatovenerological Soc Slovenia |
publishDate |
2019 |
url |
https://hdl.handle.net/20.500.12684/5421 https://doi.org/10.15570/actaapa.2019.15 |
genre |
SCAR |
genre_facet |
SCAR |
op_relation |
10.15570/actaapa.2019.15 Acta Dermatovenerologica Alpina Pannonica Et Adriatica Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı 1318-4458 1581-2979 https://doi.org/10.15570/actaapa.2019.15 https://hdl.handle.net/20.500.12684/5421 28 2 57 59 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/20.500.12684/5421 https://doi.org/10.15570/actaapa.2019.15 |
_version_ |
1766188377018728448 |