Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland
There has been limited knowledge on spatio-temporal epidemiology of zoonotic arctic fox rabies among countries bordering the Arctic, in particular Greenland. Previous molecular epidemiological studies have suggested the occurrence of one particular arctic rabies virus (RABV) lineage (arctic-3), but...
Published in: | PLOS Neglected Tropical Diseases |
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2016
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ftdtupubl:oai:pure.atira.dk:publications/ea8c62c2-aa96-44c8-822a-7ba0c2a50259 2024-09-15T17:51:26+00:00 Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland Hanke, Dennis Freuling, Conrad M. Fischer, Susanne Hueffer, Karsten Hundertmark, Kris Nadin-Davis, Susan Marston, Denise Fooks, Anthony R. Bøtner, Anette Mettenleiter, Thomas C. Beer, Martin Rasmussen, Thomas Bruun Müller, Thomas F. Höper, Dirk 2016 application/pdf https://orbit.dtu.dk/en/publications/ea8c62c2-aa96-44c8-822a-7ba0c2a50259 https://doi.org/10.1371/journal.pntd.0004779 https://backend.orbit.dtu.dk/ws/files/125526527/pntd.0004779.pdf eng eng https://orbit.dtu.dk/en/publications/ea8c62c2-aa96-44c8-822a-7ba0c2a50259 info:eu-repo/semantics/openAccess Hanke , D , Freuling , C M , Fischer , S , Hueffer , K , Hundertmark , K , Nadin-Davis , S , Marston , D , Fooks , A R , Bøtner , A , Mettenleiter , T C , Beer , M , Rasmussen , T B , Müller , T F & Höper , D 2016 , ' Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland ' , P L o S Neglected Tropical Diseases (Online) , vol. 10 , no. 7 , e0004779 . https://doi.org/10.1371/journal.pntd.0004779 /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2016 ftdtupubl https://doi.org/10.1371/journal.pntd.0004779 2024-07-29T23:50:17Z There has been limited knowledge on spatio-temporal epidemiology of zoonotic arctic fox rabies among countries bordering the Arctic, in particular Greenland. Previous molecular epidemiological studies have suggested the occurrence of one particular arctic rabies virus (RABV) lineage (arctic-3), but have been limited by a low number of available samples preventing in-depth high resolution phylogenetic analysis of RABVs at that time. However, an improved knowledge of the evolution, at a molecular level, of the circulating RABVs and a better understanding of the historical perspective of the disease in Greenland is necessary for better direct control measures on the island. These issues have been addressed by investigating the spatio-temporal genetic diversity of arctic RABVs and their reservoir host, the arctic fox, in Greenland using both full and partial genome sequences. Using a unique set of 79 arctic RABV full genome sequences from Greenland, Canada, USA (Alaska) and Russia obtained between 1977 and 2014, a description of the historic context in relation to the genetic diversity of currently circulating RABV in Greenland and neighboring Canadian Northern territories has been provided. The phylogenetic analysis confirmed delineation into four major arctic RABV lineages (arctic 1–4) with viruses from Greenland exclusively grouping into the circumpolar arctic-3 lineage. High resolution analysis enabled distinction of seven geographically distinct subclades (3.I – 3.VII) with two subclades containing viruses from both Greenland and Canada. By combining analysis of full length RABV genome sequences and host derived sequences encoding mitochondrial proteins obtained simultaneously from brain tissues of 49 arctic foxes, the interaction of viruses and their hosts was explored in detail. Such an approach can serve as a blueprint for analysis of infectious disease dynamics and virus-host interdependencies. The results showed a fine-scale spatial population structure in Greenland arctic foxes based on mitochondrial ... Article in Journal/Newspaper Arctic Arctic Fox Arctic Greenland Alaska Technical University of Denmark: DTU Orbit PLOS Neglected Tropical Diseases 10 7 e0004779 |
institution |
Open Polar |
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Technical University of Denmark: DTU Orbit |
op_collection_id |
ftdtupubl |
language |
English |
topic |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Hanke, Dennis Freuling, Conrad M. Fischer, Susanne Hueffer, Karsten Hundertmark, Kris Nadin-Davis, Susan Marston, Denise Fooks, Anthony R. Bøtner, Anette Mettenleiter, Thomas C. Beer, Martin Rasmussen, Thomas Bruun Müller, Thomas F. Höper, Dirk Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
topic_facet |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
There has been limited knowledge on spatio-temporal epidemiology of zoonotic arctic fox rabies among countries bordering the Arctic, in particular Greenland. Previous molecular epidemiological studies have suggested the occurrence of one particular arctic rabies virus (RABV) lineage (arctic-3), but have been limited by a low number of available samples preventing in-depth high resolution phylogenetic analysis of RABVs at that time. However, an improved knowledge of the evolution, at a molecular level, of the circulating RABVs and a better understanding of the historical perspective of the disease in Greenland is necessary for better direct control measures on the island. These issues have been addressed by investigating the spatio-temporal genetic diversity of arctic RABVs and their reservoir host, the arctic fox, in Greenland using both full and partial genome sequences. Using a unique set of 79 arctic RABV full genome sequences from Greenland, Canada, USA (Alaska) and Russia obtained between 1977 and 2014, a description of the historic context in relation to the genetic diversity of currently circulating RABV in Greenland and neighboring Canadian Northern territories has been provided. The phylogenetic analysis confirmed delineation into four major arctic RABV lineages (arctic 1–4) with viruses from Greenland exclusively grouping into the circumpolar arctic-3 lineage. High resolution analysis enabled distinction of seven geographically distinct subclades (3.I – 3.VII) with two subclades containing viruses from both Greenland and Canada. By combining analysis of full length RABV genome sequences and host derived sequences encoding mitochondrial proteins obtained simultaneously from brain tissues of 49 arctic foxes, the interaction of viruses and their hosts was explored in detail. Such an approach can serve as a blueprint for analysis of infectious disease dynamics and virus-host interdependencies. The results showed a fine-scale spatial population structure in Greenland arctic foxes based on mitochondrial ... |
format |
Article in Journal/Newspaper |
author |
Hanke, Dennis Freuling, Conrad M. Fischer, Susanne Hueffer, Karsten Hundertmark, Kris Nadin-Davis, Susan Marston, Denise Fooks, Anthony R. Bøtner, Anette Mettenleiter, Thomas C. Beer, Martin Rasmussen, Thomas Bruun Müller, Thomas F. Höper, Dirk |
author_facet |
Hanke, Dennis Freuling, Conrad M. Fischer, Susanne Hueffer, Karsten Hundertmark, Kris Nadin-Davis, Susan Marston, Denise Fooks, Anthony R. Bøtner, Anette Mettenleiter, Thomas C. Beer, Martin Rasmussen, Thomas Bruun Müller, Thomas F. Höper, Dirk |
author_sort |
Hanke, Dennis |
title |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_short |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_full |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_fullStr |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_full_unstemmed |
Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland |
title_sort |
spatio-temporal analysis of the genetic diversity of arctic rabies viruses and their reservoir hosts in greenland |
publishDate |
2016 |
url |
https://orbit.dtu.dk/en/publications/ea8c62c2-aa96-44c8-822a-7ba0c2a50259 https://doi.org/10.1371/journal.pntd.0004779 https://backend.orbit.dtu.dk/ws/files/125526527/pntd.0004779.pdf |
genre |
Arctic Arctic Fox Arctic Greenland Alaska |
genre_facet |
Arctic Arctic Fox Arctic Greenland Alaska |
op_source |
Hanke , D , Freuling , C M , Fischer , S , Hueffer , K , Hundertmark , K , Nadin-Davis , S , Marston , D , Fooks , A R , Bøtner , A , Mettenleiter , T C , Beer , M , Rasmussen , T B , Müller , T F & Höper , D 2016 , ' Spatio-temporal Analysis of the Genetic Diversity of Arctic Rabies Viruses and Their Reservoir Hosts in Greenland ' , P L o S Neglected Tropical Diseases (Online) , vol. 10 , no. 7 , e0004779 . https://doi.org/10.1371/journal.pntd.0004779 |
op_relation |
https://orbit.dtu.dk/en/publications/ea8c62c2-aa96-44c8-822a-7ba0c2a50259 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pntd.0004779 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
7 |
container_start_page |
e0004779 |
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1810293341833658368 |