Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)?
There is a great need for understanding the impact from dietary OHCs (organohalogen compounds) on bone mineral composition - and thereby osteoporosis - in especially arctic wildlife such as polar bears (Ursus maritimus) as well as humans. For that purpose, we measured BMD (bone mineral density) by D...
Published in: | Environment International |
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2008
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Online Access: | https://orbit.dtu.dk/en/publications/d6fe73f5-2add-469c-a8d2-6c0ab1774f0b https://doi.org/10.1016/j.envint.2008.01.009 |
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ftdtupubl:oai:pure.atira.dk:publications/d6fe73f5-2add-469c-a8d2-6c0ab1774f0b 2023-05-15T15:15:30+02:00 Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? Sonne, Christian Riget, Frank F. Jensen, Jens-Erik Beck Hyldstrup, Lars Teilmann, Jenni Dietz, Rune Kirkegaard, Maja Andersen, Steen Letcher, Robert J Jakobsen, Jette 2008 https://orbit.dtu.dk/en/publications/d6fe73f5-2add-469c-a8d2-6c0ab1774f0b https://doi.org/10.1016/j.envint.2008.01.009 eng eng info:eu-repo/semantics/restrictedAccess Sonne , C , Riget , F F , Jensen , J-E B , Hyldstrup , L , Teilmann , J , Dietz , R , Kirkegaard , M , Andersen , S , Letcher , R J & Jakobsen , J 2008 , ' Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? ' , Environment International , vol. 34 , no. 6 , pp. 811-820 . https://doi.org/10.1016/j.envint.2008.01.009 article 2008 ftdtupubl https://doi.org/10.1016/j.envint.2008.01.009 2023-01-11T23:54:40Z There is a great need for understanding the impact from dietary OHCs (organohalogen compounds) on bone mineral composition - and thereby osteoporosis - in especially arctic wildlife such as polar bears (Ursus maritimus) as well as humans. For that purpose, we measured BMD (bone mineral density) by DXA scanning (g/cm(-2)) in 15 age and weight normalized sledge dog (Canis familiaris) bitches and their 26 pups divided into a control group (n = 26) given 50-200 g/day clean pork (Suis scrofa) fat and a treated group (n = 15) given 50-200 g/day OHC polluted minke whale (Balaenoptera acutorostrata) blubber as main lipid sources. The results showed that BMD increased significantly with age (linear regression: p 0.0001, r(2)=0.83, n=41) while no sex difference was found in the F-generation (two-way ANOVA: all p>0.3). No differences in BMDfemur or BMDvertebrae between exposed and control individuals in the bitch generation were found (linear mixed effect model: both p > 0.38). Likewise, no difference between exposed and control subadults and juveniles in the F-generation was found (two-way ANOVA: all p>0.33). Correlation analyses between BMDfemur, BMDvertebrae and groups of OHCs, respectively, did not show any statistically significant relationships nor a clear or decreasing trend (Pearson's: p: 0.07-0.78; r: -0.2-0.59; n: 10-18). As the groups were similar regarding genetics, age and sex are the only factors that can explain this observation. Either the pollutants did not have an impact on BMD using the present time frame and OHC concentrations (threshold levels not reached), or the difference in food composition (mainly vitamins and n3 fatty acids) conceal the potential OHC impact on BMD. Such information is important when evaluating the positive and negative health consequences from eating polluted marine species. (C) 2008 Elsevier Ltd. All rights reserved. Article in Journal/Newspaper Arctic Balaenoptera acutorostrata Greenland minke whale Ursus maritimus Technical University of Denmark: DTU Orbit Arctic Greenland Environment International 34 6 811 820 |
institution |
Open Polar |
collection |
Technical University of Denmark: DTU Orbit |
op_collection_id |
ftdtupubl |
language |
English |
description |
There is a great need for understanding the impact from dietary OHCs (organohalogen compounds) on bone mineral composition - and thereby osteoporosis - in especially arctic wildlife such as polar bears (Ursus maritimus) as well as humans. For that purpose, we measured BMD (bone mineral density) by DXA scanning (g/cm(-2)) in 15 age and weight normalized sledge dog (Canis familiaris) bitches and their 26 pups divided into a control group (n = 26) given 50-200 g/day clean pork (Suis scrofa) fat and a treated group (n = 15) given 50-200 g/day OHC polluted minke whale (Balaenoptera acutorostrata) blubber as main lipid sources. The results showed that BMD increased significantly with age (linear regression: p 0.0001, r(2)=0.83, n=41) while no sex difference was found in the F-generation (two-way ANOVA: all p>0.3). No differences in BMDfemur or BMDvertebrae between exposed and control individuals in the bitch generation were found (linear mixed effect model: both p > 0.38). Likewise, no difference between exposed and control subadults and juveniles in the F-generation was found (two-way ANOVA: all p>0.33). Correlation analyses between BMDfemur, BMDvertebrae and groups of OHCs, respectively, did not show any statistically significant relationships nor a clear or decreasing trend (Pearson's: p: 0.07-0.78; r: -0.2-0.59; n: 10-18). As the groups were similar regarding genetics, age and sex are the only factors that can explain this observation. Either the pollutants did not have an impact on BMD using the present time frame and OHC concentrations (threshold levels not reached), or the difference in food composition (mainly vitamins and n3 fatty acids) conceal the potential OHC impact on BMD. Such information is important when evaluating the positive and negative health consequences from eating polluted marine species. (C) 2008 Elsevier Ltd. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
Sonne, Christian Riget, Frank F. Jensen, Jens-Erik Beck Hyldstrup, Lars Teilmann, Jenni Dietz, Rune Kirkegaard, Maja Andersen, Steen Letcher, Robert J Jakobsen, Jette |
spellingShingle |
Sonne, Christian Riget, Frank F. Jensen, Jens-Erik Beck Hyldstrup, Lars Teilmann, Jenni Dietz, Rune Kirkegaard, Maja Andersen, Steen Letcher, Robert J Jakobsen, Jette Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? |
author_facet |
Sonne, Christian Riget, Frank F. Jensen, Jens-Erik Beck Hyldstrup, Lars Teilmann, Jenni Dietz, Rune Kirkegaard, Maja Andersen, Steen Letcher, Robert J Jakobsen, Jette |
author_sort |
Sonne, Christian |
title |
Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? |
title_short |
Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? |
title_full |
Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? |
title_fullStr |
Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? |
title_full_unstemmed |
Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? |
title_sort |
does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in greenland sledge dogs (canis familiaris)? |
publishDate |
2008 |
url |
https://orbit.dtu.dk/en/publications/d6fe73f5-2add-469c-a8d2-6c0ab1774f0b https://doi.org/10.1016/j.envint.2008.01.009 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Balaenoptera acutorostrata Greenland minke whale Ursus maritimus |
genre_facet |
Arctic Balaenoptera acutorostrata Greenland minke whale Ursus maritimus |
op_source |
Sonne , C , Riget , F F , Jensen , J-E B , Hyldstrup , L , Teilmann , J , Dietz , R , Kirkegaard , M , Andersen , S , Letcher , R J & Jakobsen , J 2008 , ' Does the nutrition profile of vitamins, fatty acids and microelements counteract the negative impact from organohalogen pollutants on bone mineral density in Greenland sledge dogs (Canis familiaris)? ' , Environment International , vol. 34 , no. 6 , pp. 811-820 . https://doi.org/10.1016/j.envint.2008.01.009 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.envint.2008.01.009 |
container_title |
Environment International |
container_volume |
34 |
container_issue |
6 |
container_start_page |
811 |
op_container_end_page |
820 |
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1766345868478251008 |