Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid
Peracetic acid (PAA), a strong organic peroxide, is considered a relatively sustainable disinfectant in aquaculture because of its broad effectivity against many pathogens at low concentrations and because it degrades spontaneously to harmless residues. The impacts of PAA on fish health must be dete...
Published in: | Fish & Shellfish Immunology |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2019
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Online Access: | https://orbit.dtu.dk/en/publications/c493465f-b2ff-4dd1-ad93-4144f1c26dd4 https://doi.org/10.1016/j.fsi.2019.08.048 https://backend.orbit.dtu.dk/ws/files/190438184/untitled.pdf |
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ftdtupubl:oai:pure.atira.dk:publications/c493465f-b2ff-4dd1-ad93-4144f1c26dd4 2024-06-23T07:51:22+00:00 Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid Soleng, Malene Johansen, Lill-Heidi Johnsen, Hanne Johansson, Gunhild S Breiland, Mette W Rørmark, Lisbeth Pittman, Karin Pedersen, Lars-Flemming Lazado, Carlo Cabacang 2019 application/pdf https://orbit.dtu.dk/en/publications/c493465f-b2ff-4dd1-ad93-4144f1c26dd4 https://doi.org/10.1016/j.fsi.2019.08.048 https://backend.orbit.dtu.dk/ws/files/190438184/untitled.pdf eng eng https://orbit.dtu.dk/en/publications/c493465f-b2ff-4dd1-ad93-4144f1c26dd4 info:eu-repo/semantics/openAccess Soleng , M , Johansen , L-H , Johnsen , H , Johansson , G S , Breiland , M W , Rørmark , L , Pittman , K , Pedersen , L-F & Lazado , C C 2019 , ' Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid ' , Fish and Shellfish Immunology , vol. 93 , pp. 895-903 . https://doi.org/10.1016/j.fsi.2019.08.048 Amoebic gill disease Disinfectant Peracetic acid Peroxide Stress response article 2019 ftdtupubl https://doi.org/10.1016/j.fsi.2019.08.048 2024-06-04T15:22:33Z Peracetic acid (PAA), a strong organic peroxide, is considered a relatively sustainable disinfectant in aquaculture because of its broad effectivity against many pathogens at low concentrations and because it degrades spontaneously to harmless residues. The impacts of PAA on fish health must be determined before its use as either a routine disinfectant or chemotherapeutant. Here we investigated the systemic and mucosal stress responses of Atlantic salmon ( Salmo salar ) to PAA. In experiment 1, salmon were exposed to different nominal concentrations (0, 0.6, and 2.4 ppm) of PAA for 5 min, followed by a re-exposure to the same concentrations for 30 min 2 weeks later. Sampling was performed before exposure to PAA and at 2 h, 48 h, and 2 w after exposures. In experiment 2, fish were subjected to crowding stress prior to PAA exposure at 4.8 ppm for 30 min. The fish were sampled before exposure and 1 h, 4 h, and 2 w after. The two trials were performed in a recirculation system. Both systemic (i.e., plasma cortisol, glucose, lactate, total antioxidant capacity) and mucosal (i.e., expression of antioxidant coding genes in the skin and gills) stress indicators were affected by the treatments at varying levels, and it was apparent that the fish were able to mount a robust response to the physiological demands of PAA exposure. The cortisol levels increased in the early hours after exposure and returned to basal level afterwards. Prior exposure history to PAA did not markedly affect the levels of plasma lactate and glucose when fish were re-exposed to PAA. Crowding stress before PAA treatment, however, did alter some of the stress indicators (i.e., lactate, glucose and expression of antioxidant genes in the gills), suggesting that stress history serves as both a confounding and compounding factor on how stress responses to PAA are mobilised. Nonetheless, the changes were not substantial. Gene expression profile analyses revealed that the antioxidant system was more responsive to PAA in the gills than in the skin. The ... Article in Journal/Newspaper Atlantic salmon Salmo salar Technical University of Denmark: DTU Orbit Paa ENVELOPE(-53.483,-53.483,66.017,66.017) Fish & Shellfish Immunology 93 895 903 |
institution |
Open Polar |
collection |
Technical University of Denmark: DTU Orbit |
op_collection_id |
ftdtupubl |
language |
English |
topic |
Amoebic gill disease Disinfectant Peracetic acid Peroxide Stress response |
spellingShingle |
Amoebic gill disease Disinfectant Peracetic acid Peroxide Stress response Soleng, Malene Johansen, Lill-Heidi Johnsen, Hanne Johansson, Gunhild S Breiland, Mette W Rørmark, Lisbeth Pittman, Karin Pedersen, Lars-Flemming Lazado, Carlo Cabacang Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid |
topic_facet |
Amoebic gill disease Disinfectant Peracetic acid Peroxide Stress response |
description |
Peracetic acid (PAA), a strong organic peroxide, is considered a relatively sustainable disinfectant in aquaculture because of its broad effectivity against many pathogens at low concentrations and because it degrades spontaneously to harmless residues. The impacts of PAA on fish health must be determined before its use as either a routine disinfectant or chemotherapeutant. Here we investigated the systemic and mucosal stress responses of Atlantic salmon ( Salmo salar ) to PAA. In experiment 1, salmon were exposed to different nominal concentrations (0, 0.6, and 2.4 ppm) of PAA for 5 min, followed by a re-exposure to the same concentrations for 30 min 2 weeks later. Sampling was performed before exposure to PAA and at 2 h, 48 h, and 2 w after exposures. In experiment 2, fish were subjected to crowding stress prior to PAA exposure at 4.8 ppm for 30 min. The fish were sampled before exposure and 1 h, 4 h, and 2 w after. The two trials were performed in a recirculation system. Both systemic (i.e., plasma cortisol, glucose, lactate, total antioxidant capacity) and mucosal (i.e., expression of antioxidant coding genes in the skin and gills) stress indicators were affected by the treatments at varying levels, and it was apparent that the fish were able to mount a robust response to the physiological demands of PAA exposure. The cortisol levels increased in the early hours after exposure and returned to basal level afterwards. Prior exposure history to PAA did not markedly affect the levels of plasma lactate and glucose when fish were re-exposed to PAA. Crowding stress before PAA treatment, however, did alter some of the stress indicators (i.e., lactate, glucose and expression of antioxidant genes in the gills), suggesting that stress history serves as both a confounding and compounding factor on how stress responses to PAA are mobilised. Nonetheless, the changes were not substantial. Gene expression profile analyses revealed that the antioxidant system was more responsive to PAA in the gills than in the skin. The ... |
format |
Article in Journal/Newspaper |
author |
Soleng, Malene Johansen, Lill-Heidi Johnsen, Hanne Johansson, Gunhild S Breiland, Mette W Rørmark, Lisbeth Pittman, Karin Pedersen, Lars-Flemming Lazado, Carlo Cabacang |
author_facet |
Soleng, Malene Johansen, Lill-Heidi Johnsen, Hanne Johansson, Gunhild S Breiland, Mette W Rørmark, Lisbeth Pittman, Karin Pedersen, Lars-Flemming Lazado, Carlo Cabacang |
author_sort |
Soleng, Malene |
title |
Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid |
title_short |
Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid |
title_full |
Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid |
title_fullStr |
Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid |
title_full_unstemmed |
Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid |
title_sort |
atlantic salmon ( salmo salar ) mounts systemic and mucosal stress responses to peracetic acid |
publishDate |
2019 |
url |
https://orbit.dtu.dk/en/publications/c493465f-b2ff-4dd1-ad93-4144f1c26dd4 https://doi.org/10.1016/j.fsi.2019.08.048 https://backend.orbit.dtu.dk/ws/files/190438184/untitled.pdf |
long_lat |
ENVELOPE(-53.483,-53.483,66.017,66.017) |
geographic |
Paa |
geographic_facet |
Paa |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Soleng , M , Johansen , L-H , Johnsen , H , Johansson , G S , Breiland , M W , Rørmark , L , Pittman , K , Pedersen , L-F & Lazado , C C 2019 , ' Atlantic salmon ( Salmo salar ) mounts systemic and mucosal stress responses to peracetic acid ' , Fish and Shellfish Immunology , vol. 93 , pp. 895-903 . https://doi.org/10.1016/j.fsi.2019.08.048 |
op_relation |
https://orbit.dtu.dk/en/publications/c493465f-b2ff-4dd1-ad93-4144f1c26dd4 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.fsi.2019.08.048 |
container_title |
Fish & Shellfish Immunology |
container_volume |
93 |
container_start_page |
895 |
op_container_end_page |
903 |
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1802642448842752000 |