Altered vitamin D status in liver tissue and blood plasma from Greenland sledge dogs (Canis familiaris) dietary exposed to organohalogen contaminated minke whale (Balaenoptera acuterostrata) blubber

• Published in: Ecotoxicology and Environmental Safety
• Main Authors: Sonne, Christian, Kirkegaard, Maja, Jakobsen, Jette, Jenssen, Bjørn Munro, Letcher, Robert J., Dietz, Rune
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2014
• Subjects: 25-Hydroxyvitamin D3; Sledge dogs; Organohalogen contaminants; PCBs; Polychlorinated biphenyls; Vitamin D3; Greenland; minke whale
• Online Access: https://orbit.dtu.dk/en/publications/9ae06ab4-6e0d-4a41-8077-8bf29b92b8a0; https://doi.org/10.1016/j.ecoenv.2013.11.017

This study compared vitamin D3 (vitD3) and 25-OH vitamin D3 (25OHD3) status in Greenland sledge dogs (Canis familiaris) given either minke whale (Balaenoptera acuterostrata) blubber high in organohalogen contaminants (OHCs) or clean porcine (Suis scrofa) fat for up to 636 days. A group of six exposed and six control sister bitches (maternal generation) and their three exposed and four control pups, respectively, were daily fed 112g whale blubber (193µg ∑PCB/day) or porcine fat (0.17µg ∑PCB/day). Mean level of ∑PCB in adipose tissue of exposed bitches and their pups was 3106 and 2670ng/g lw, respectively, which was significantly higher than the mean concentration of 53ng/g lw for all controls (p