Patulin and secondary metabolite production by marine-derived Penicillium strains
Genus Penicillium represents an important fungal group regarding to its mycotoxin production. Secondary metabolomes of eight marine-derived strains belonging to subgenera Furcatum and Penicillium were investigated using dereplication by liquid chromatography (LC)–Diode Array Detector (DAD)–mass spec...
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2012
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Online Access: | https://orbit.dtu.dk/en/publications/91646ab2-e3a3-4dd7-9ec3-6807bae62395 https://doi.org/10.1016/j.funbio.2012.06.005 |
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ftdtupubl:oai:pure.atira.dk:publications/91646ab2-e3a3-4dd7-9ec3-6807bae62395 2024-05-12T07:56:17+00:00 Patulin and secondary metabolite production by marine-derived Penicillium strains Vansteelandt, Marieke Kerzaon, Isabelle Blanchet, Elodie Fossi Tankoua, Olivia Robiou Du Pont, Thibaut Joubert, Yolaine Monteau, Fabrice Le Bizec, Bruno Frisvad, Jens C. Pouchus, Yves François Grovel, Olivier 2012 https://orbit.dtu.dk/en/publications/91646ab2-e3a3-4dd7-9ec3-6807bae62395 https://doi.org/10.1016/j.funbio.2012.06.005 eng eng https://orbit.dtu.dk/en/publications/91646ab2-e3a3-4dd7-9ec3-6807bae62395 info:eu-repo/semantics/closedAccess Vansteelandt , M , Kerzaon , I , Blanchet , E , Fossi Tankoua , O , Robiou Du Pont , T , Joubert , Y , Monteau , F , Le Bizec , B , Frisvad , J C , Pouchus , Y F & Grovel , O 2012 , ' Patulin and secondary metabolite production by marine-derived Penicillium strains ' , Fungal Biology , vol. 116 , no. 9 , pp. 954-961 . https://doi.org/10.1016/j.funbio.2012.06.005 LC–DAD–MS/MS dereplication Marine-derived Penicillium Neuroactivity Patulin Secondary metabolites Subgenus Furcatum /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water article 2012 ftdtupubl https://doi.org/10.1016/j.funbio.2012.06.005 2024-04-17T14:55:12Z Genus Penicillium represents an important fungal group regarding to its mycotoxin production. Secondary metabolomes of eight marine-derived strains belonging to subgenera Furcatum and Penicillium were investigated using dereplication by liquid chromatography (LC)–Diode Array Detector (DAD)–mass spectrometry (MS)/MS. Each strain was grown on six different culture media to enhance the number of observable metabolites.Thirty-two secondary metabolites were detected in crude extracts with twenty first observations for studied species. Patulin, a major mycotoxin, was classically detected in extracts of Penicillium expansum, and was also isolated from Penicillium antarcticum cultures, whose secondary metabolome is still to be done. These detections constituted the first descriptions of patulin in marine strains of Penicillium, highlighting the risk for shellfish and their consumers due to the presence of these fungi in shellfish farming areas.Patulin induced acute neurotoxicity on Diptera larvae, indicating the interest of this bioassay as an additional tool for detection of this major mycotoxin in crude extracts. Article in Journal/Newspaper Antarc* Technical University of Denmark: DTU Orbit Fungal Biology 116 9 954 961 |
institution |
Open Polar |
collection |
Technical University of Denmark: DTU Orbit |
op_collection_id |
ftdtupubl |
language |
English |
topic |
LC–DAD–MS/MS dereplication Marine-derived Penicillium Neuroactivity Patulin Secondary metabolites Subgenus Furcatum /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water |
spellingShingle |
LC–DAD–MS/MS dereplication Marine-derived Penicillium Neuroactivity Patulin Secondary metabolites Subgenus Furcatum /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water Vansteelandt, Marieke Kerzaon, Isabelle Blanchet, Elodie Fossi Tankoua, Olivia Robiou Du Pont, Thibaut Joubert, Yolaine Monteau, Fabrice Le Bizec, Bruno Frisvad, Jens C. Pouchus, Yves François Grovel, Olivier Patulin and secondary metabolite production by marine-derived Penicillium strains |
topic_facet |
LC–DAD–MS/MS dereplication Marine-derived Penicillium Neuroactivity Patulin Secondary metabolites Subgenus Furcatum /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water |
description |
Genus Penicillium represents an important fungal group regarding to its mycotoxin production. Secondary metabolomes of eight marine-derived strains belonging to subgenera Furcatum and Penicillium were investigated using dereplication by liquid chromatography (LC)–Diode Array Detector (DAD)–mass spectrometry (MS)/MS. Each strain was grown on six different culture media to enhance the number of observable metabolites.Thirty-two secondary metabolites were detected in crude extracts with twenty first observations for studied species. Patulin, a major mycotoxin, was classically detected in extracts of Penicillium expansum, and was also isolated from Penicillium antarcticum cultures, whose secondary metabolome is still to be done. These detections constituted the first descriptions of patulin in marine strains of Penicillium, highlighting the risk for shellfish and their consumers due to the presence of these fungi in shellfish farming areas.Patulin induced acute neurotoxicity on Diptera larvae, indicating the interest of this bioassay as an additional tool for detection of this major mycotoxin in crude extracts. |
format |
Article in Journal/Newspaper |
author |
Vansteelandt, Marieke Kerzaon, Isabelle Blanchet, Elodie Fossi Tankoua, Olivia Robiou Du Pont, Thibaut Joubert, Yolaine Monteau, Fabrice Le Bizec, Bruno Frisvad, Jens C. Pouchus, Yves François Grovel, Olivier |
author_facet |
Vansteelandt, Marieke Kerzaon, Isabelle Blanchet, Elodie Fossi Tankoua, Olivia Robiou Du Pont, Thibaut Joubert, Yolaine Monteau, Fabrice Le Bizec, Bruno Frisvad, Jens C. Pouchus, Yves François Grovel, Olivier |
author_sort |
Vansteelandt, Marieke |
title |
Patulin and secondary metabolite production by marine-derived Penicillium strains |
title_short |
Patulin and secondary metabolite production by marine-derived Penicillium strains |
title_full |
Patulin and secondary metabolite production by marine-derived Penicillium strains |
title_fullStr |
Patulin and secondary metabolite production by marine-derived Penicillium strains |
title_full_unstemmed |
Patulin and secondary metabolite production by marine-derived Penicillium strains |
title_sort |
patulin and secondary metabolite production by marine-derived penicillium strains |
publishDate |
2012 |
url |
https://orbit.dtu.dk/en/publications/91646ab2-e3a3-4dd7-9ec3-6807bae62395 https://doi.org/10.1016/j.funbio.2012.06.005 |
genre |
Antarc* |
genre_facet |
Antarc* |
op_source |
Vansteelandt , M , Kerzaon , I , Blanchet , E , Fossi Tankoua , O , Robiou Du Pont , T , Joubert , Y , Monteau , F , Le Bizec , B , Frisvad , J C , Pouchus , Y F & Grovel , O 2012 , ' Patulin and secondary metabolite production by marine-derived Penicillium strains ' , Fungal Biology , vol. 116 , no. 9 , pp. 954-961 . https://doi.org/10.1016/j.funbio.2012.06.005 |
op_relation |
https://orbit.dtu.dk/en/publications/91646ab2-e3a3-4dd7-9ec3-6807bae62395 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.funbio.2012.06.005 |
container_title |
Fungal Biology |
container_volume |
116 |
container_issue |
9 |
container_start_page |
954 |
op_container_end_page |
961 |
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1798836274910461952 |