Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data
This paper presents an integrated model of convective O 2 -transport, aerobic dive limits (ADL), and thermochemical data for oxygen binding to mutant myoglobin (Mb), used to quantify the impact of mutations in Mb on the dive limits of Weddell seals ( Leptonychotes weddellii ). We find that wild-type...
Published in: | Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Online Access: | https://orbit.dtu.dk/en/publications/8c34d3ac-4289-4b97-9011-ddcf9741200b https://doi.org/10.1016/j.cbpa.2012.10.010 |
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ftdtupubl:oai:pure.atira.dk:publications/8c34d3ac-4289-4b97-9011-ddcf9741200b 2023-05-15T18:43:24+02:00 Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data Dasmeh, Pouria Davis, Randall W. Kepp, Kasper Planeta 2013 https://orbit.dtu.dk/en/publications/8c34d3ac-4289-4b97-9011-ddcf9741200b https://doi.org/10.1016/j.cbpa.2012.10.010 eng eng info:eu-repo/semantics/closedAccess Dasmeh , P , Davis , R W & Kepp , K P 2013 , ' Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data ' , Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology , vol. 164 , pp. 119-128 . https://doi.org/10.1016/j.cbpa.2012.10.010 Myoglobin Aerobic dive limit Protein mutations Fitness Seals article 2013 ftdtupubl https://doi.org/10.1016/j.cbpa.2012.10.010 2023-01-04T23:58:14Z This paper presents an integrated model of convective O 2 -transport, aerobic dive limits (ADL), and thermochemical data for oxygen binding to mutant myoglobin (Mb), used to quantify the impact of mutations in Mb on the dive limits of Weddell seals ( Leptonychotes weddellii ). We find that wild-type Mb traits are only superior under specific behavioral and physiological conditions that critically prolong the ADL, action radius, and fitness of the seals. As an extreme example, the mutations in the conserved His-64 reduce ADL up to 14±2 min for routine aerobic dives, whereas many other mutations are nearly neutral in terms of ADL and the inferred fitness. We also find that the cardiac system, the muscle O 2 -store, animal behavior (i.e. pre-dive ventilation), and the oxygen binding affinity of Mb, K O2 , have co-evolved to optimize dive duration at routine aerobic diving conditions, suggesting that such conditions are mostly selected upon in seals. The model is capable of roughly quantifying the physiological impact of single-protein mutations and thus bridges an important gap between animal physiology and molecular (protein) evolution. Article in Journal/Newspaper Weddell Seals Technical University of Denmark: DTU Orbit Weddell Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 164 1 119 128 |
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Open Polar |
collection |
Technical University of Denmark: DTU Orbit |
op_collection_id |
ftdtupubl |
language |
English |
topic |
Myoglobin Aerobic dive limit Protein mutations Fitness Seals |
spellingShingle |
Myoglobin Aerobic dive limit Protein mutations Fitness Seals Dasmeh, Pouria Davis, Randall W. Kepp, Kasper Planeta Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data |
topic_facet |
Myoglobin Aerobic dive limit Protein mutations Fitness Seals |
description |
This paper presents an integrated model of convective O 2 -transport, aerobic dive limits (ADL), and thermochemical data for oxygen binding to mutant myoglobin (Mb), used to quantify the impact of mutations in Mb on the dive limits of Weddell seals ( Leptonychotes weddellii ). We find that wild-type Mb traits are only superior under specific behavioral and physiological conditions that critically prolong the ADL, action radius, and fitness of the seals. As an extreme example, the mutations in the conserved His-64 reduce ADL up to 14±2 min for routine aerobic dives, whereas many other mutations are nearly neutral in terms of ADL and the inferred fitness. We also find that the cardiac system, the muscle O 2 -store, animal behavior (i.e. pre-dive ventilation), and the oxygen binding affinity of Mb, K O2 , have co-evolved to optimize dive duration at routine aerobic diving conditions, suggesting that such conditions are mostly selected upon in seals. The model is capable of roughly quantifying the physiological impact of single-protein mutations and thus bridges an important gap between animal physiology and molecular (protein) evolution. |
format |
Article in Journal/Newspaper |
author |
Dasmeh, Pouria Davis, Randall W. Kepp, Kasper Planeta |
author_facet |
Dasmeh, Pouria Davis, Randall W. Kepp, Kasper Planeta |
author_sort |
Dasmeh, Pouria |
title |
Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data |
title_short |
Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data |
title_full |
Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data |
title_fullStr |
Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data |
title_full_unstemmed |
Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data |
title_sort |
aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data |
publishDate |
2013 |
url |
https://orbit.dtu.dk/en/publications/8c34d3ac-4289-4b97-9011-ddcf9741200b https://doi.org/10.1016/j.cbpa.2012.10.010 |
geographic |
Weddell |
geographic_facet |
Weddell |
genre |
Weddell Seals |
genre_facet |
Weddell Seals |
op_source |
Dasmeh , P , Davis , R W & Kepp , K P 2013 , ' Aerobic dive limits of seals with mutant myoglobin using combined thermochemical and physiological data ' , Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology , vol. 164 , pp. 119-128 . https://doi.org/10.1016/j.cbpa.2012.10.010 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.cbpa.2012.10.010 |
container_title |
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology |
container_volume |
164 |
container_issue |
1 |
container_start_page |
119 |
op_container_end_page |
128 |
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1766233796007428096 |