A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene.
Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors....
Published in: | European Journal of Human Genetics |
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ftdtupubl:oai:pure.atira.dk:publications/87c63149-d8c1-4220-8540-c9507dbd9027 2023-12-10T09:48:30+01:00 A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. Gregersen, Noomi Dahl, Hans A. Buttenschön, Henriette N. Nyegaard, Mette Hedemand, Anne Als, Thomas Damm Wang, August G. Joensen, Sofus Woldbye, David P.D. Koefoed, Pernille Kristensen, Ann S. Kruse, Torben A. Börglum, Anders D. Mors, Ole 2012 https://orbit.dtu.dk/en/publications/87c63149-d8c1-4220-8540-c9507dbd9027 https://doi.org/10.1038/ejhg.2011.148 eng eng info:eu-repo/semantics/closedAccess Gregersen , N , Dahl , H A , Buttenschön , H N , Nyegaard , M , Hedemand , A , Als , T D , Wang , A G , Joensen , S , Woldbye , D P D , Koefoed , P , Kristensen , A S , Kruse , T A , Börglum , A D & Mors , O 2012 , ' A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. ' , European Journal of Human Genetics , vol. 20 , no. 1 , pp. 84-90 . https://doi.org/10.1038/ejhg.2011.148 /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being SDG 3 - Good Health and Well-being article 2012 ftdtupubl https://doi.org/10.1038/ejhg.2011.148 2023-11-15T23:56:47Z Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.European Journal of Human Genetics advance online publication, 3 August 2011; doi:10.1038/ejhg.2011.148. Article in Journal/Newspaper Faroe Islands Technical University of Denmark: DTU Orbit Faroe Islands European Journal of Human Genetics 20 1 84 90 |
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Technical University of Denmark: DTU Orbit |
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English |
topic |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being SDG 3 - Good Health and Well-being |
spellingShingle |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being SDG 3 - Good Health and Well-being Gregersen, Noomi Dahl, Hans A. Buttenschön, Henriette N. Nyegaard, Mette Hedemand, Anne Als, Thomas Damm Wang, August G. Joensen, Sofus Woldbye, David P.D. Koefoed, Pernille Kristensen, Ann S. Kruse, Torben A. Börglum, Anders D. Mors, Ole A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. |
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/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being SDG 3 - Good Health and Well-being |
description |
Panic disorder (PD) is a mental disorder with recurrent panic attacks that occur spontaneously and are not associated to any particular object or situation. There is no consensus on what causes PD. However, it is recognized that PD is influenced by environmental factors, as well as genetic factors. Despite a significant hereditary component, genetic studies have only been modestly successful in identifying genes of importance for the development of PD. In this study, we conducted a genome-wide scan using microsatellite markers and PD patients and control individuals from the isolated population of the Faroe Islands. Subsequently, we conducted a fine mapping, which revealed the amiloride-sensitive cation channel 1 (ACCN1) located on chromosome 17q11.2-q12 as a potential candidate gene for PD. The further analyses of the ACCN1 gene using single-nucleotide polymorphisms (SNPs) revealed significant association with PD in an extended Faroese case-control sample. However, analyses of a larger independent Danish case-control sample yielded no substantial significant association. This suggests that the possible risk alleles associated in the isolated population are not those involved in the development of PD in a larger outbred population.European Journal of Human Genetics advance online publication, 3 August 2011; doi:10.1038/ejhg.2011.148. |
format |
Article in Journal/Newspaper |
author |
Gregersen, Noomi Dahl, Hans A. Buttenschön, Henriette N. Nyegaard, Mette Hedemand, Anne Als, Thomas Damm Wang, August G. Joensen, Sofus Woldbye, David P.D. Koefoed, Pernille Kristensen, Ann S. Kruse, Torben A. Börglum, Anders D. Mors, Ole |
author_facet |
Gregersen, Noomi Dahl, Hans A. Buttenschön, Henriette N. Nyegaard, Mette Hedemand, Anne Als, Thomas Damm Wang, August G. Joensen, Sofus Woldbye, David P.D. Koefoed, Pernille Kristensen, Ann S. Kruse, Torben A. Börglum, Anders D. Mors, Ole |
author_sort |
Gregersen, Noomi |
title |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. |
title_short |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. |
title_full |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. |
title_fullStr |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. |
title_full_unstemmed |
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. |
title_sort |
genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. |
publishDate |
2012 |
url |
https://orbit.dtu.dk/en/publications/87c63149-d8c1-4220-8540-c9507dbd9027 https://doi.org/10.1038/ejhg.2011.148 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Gregersen , N , Dahl , H A , Buttenschön , H N , Nyegaard , M , Hedemand , A , Als , T D , Wang , A G , Joensen , S , Woldbye , D P D , Koefoed , P , Kristensen , A S , Kruse , T A , Börglum , A D & Mors , O 2012 , ' A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene. ' , European Journal of Human Genetics , vol. 20 , no. 1 , pp. 84-90 . https://doi.org/10.1038/ejhg.2011.148 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1038/ejhg.2011.148 |
container_title |
European Journal of Human Genetics |
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20 |
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1 |
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84 |
op_container_end_page |
90 |
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