Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019
Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effective...
Published in: | The Lancet Gastroenterology & Hepatology |
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Online Access: | https://orbit.dtu.dk/en/publications/6d399505-3c3b-4300-9521-d192ab605508 https://doi.org/10.1016/S2468-1253(22)00044-9 https://backend.orbit.dtu.dk/ws/files/292141432/1_s2.0_S2468125322000449_main.pdf |
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ftdtupubl:oai:pure.atira.dk:publications/6d399505-3c3b-4300-9521-d192ab605508 2024-06-23T07:53:25+00:00 Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019 2022 application/pdf https://orbit.dtu.dk/en/publications/6d399505-3c3b-4300-9521-d192ab605508 https://doi.org/10.1016/S2468-1253(22)00044-9 https://backend.orbit.dtu.dk/ws/files/292141432/1_s2.0_S2468125322000449_main.pdf eng eng https://orbit.dtu.dk/en/publications/6d399505-3c3b-4300-9521-d192ab605508 info:eu-repo/semantics/openAccess GBD 2019 Colorectal Cancer Collaborators 2022 , ' Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019 ' , The Lancet Gastroenterology and Hepatology , vol. 7 , no. 7 , pp. 627-647 . https://doi.org/10.1016/S2468-1253(22)00044-9 /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being article 2022 ftdtupubl https://doi.org/10.1016/S2468-1253(22)00044-9 2024-06-11T15:12:17Z Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods: Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990–2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings: Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408–868 574) to 2·17 million (2·00–2·34), and deaths increased from 518 126 (493 682–537 877) to 1·09 million (1·02–1·15). The global age-standardised incidence rate increased from 22·2 (95% UI 21·3–23·0) per 100 000 to 26·7 (24·6–28·9) per 100 000, whereas the age-standardised mortality rate decreased from 14·3 (13·5–14·9) per 100 000 to 13·7 (12·6–14·5) per 100 000 and the age-standardised DALY rate decreased from 308·5 (294·7–320·7) per 100 000 to 295·5 (275·2–313·0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62·0 [48·9–80·0] per 100 000), Monaco (60·7 [48·5–73·6] per 100 000), and Andorra (56·6 [42·8–71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0–37·1] per 100 000), Brunei (30·3 [26·6–34·1] per 100 000), and Hungary (28·6 [23·6–34·0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence ... Article in Journal/Newspaper Greenland Technical University of Denmark: DTU Orbit Daly ENVELOPE(63.761,63.761,-67.513,-67.513) Greenland The Lancet Gastroenterology & Hepatology 7 7 627 647 |
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Technical University of Denmark: DTU Orbit |
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English |
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/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
spellingShingle |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019 |
topic_facet |
/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being |
description |
Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods: Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990–2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings: Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408–868 574) to 2·17 million (2·00–2·34), and deaths increased from 518 126 (493 682–537 877) to 1·09 million (1·02–1·15). The global age-standardised incidence rate increased from 22·2 (95% UI 21·3–23·0) per 100 000 to 26·7 (24·6–28·9) per 100 000, whereas the age-standardised mortality rate decreased from 14·3 (13·5–14·9) per 100 000 to 13·7 (12·6–14·5) per 100 000 and the age-standardised DALY rate decreased from 308·5 (294·7–320·7) per 100 000 to 295·5 (275·2–313·0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62·0 [48·9–80·0] per 100 000), Monaco (60·7 [48·5–73·6] per 100 000), and Andorra (56·6 [42·8–71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0–37·1] per 100 000), Brunei (30·3 [26·6–34·1] per 100 000), and Hungary (28·6 [23·6–34·0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence ... |
format |
Article in Journal/Newspaper |
title |
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019 |
title_short |
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019 |
title_full |
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019 |
title_fullStr |
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019 |
title_full_unstemmed |
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the Global Burden of Disease Study 2019 |
title_sort |
global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019:a systematic analysis for the global burden of disease study 2019 |
publishDate |
2022 |
url |
https://orbit.dtu.dk/en/publications/6d399505-3c3b-4300-9521-d192ab605508 https://doi.org/10.1016/S2468-1253(22)00044-9 https://backend.orbit.dtu.dk/ws/files/292141432/1_s2.0_S2468125322000449_main.pdf |
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ENVELOPE(63.761,63.761,-67.513,-67.513) |
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Daly Greenland |
geographic_facet |
Daly Greenland |
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Greenland |
genre_facet |
Greenland |
op_source |
GBD 2019 Colorectal Cancer Collaborators 2022 , ' Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019 ' , The Lancet Gastroenterology and Hepatology , vol. 7 , no. 7 , pp. 627-647 . https://doi.org/10.1016/S2468-1253(22)00044-9 |
op_relation |
https://orbit.dtu.dk/en/publications/6d399505-3c3b-4300-9521-d192ab605508 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/S2468-1253(22)00044-9 |
container_title |
The Lancet Gastroenterology & Hepatology |
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7 |
container_issue |
7 |
container_start_page |
627 |
op_container_end_page |
647 |
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1802645055880560640 |