Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions
As already reported, the mountain hare is much more susceptible than the domestic rabbit to oral inoculation with Toxoplasma gondii, as judged by pathological changes and dissemination of parasites within the body. In the present paper, further interspecies variations are reported. Concentrations of...
Published in: | Journal of Comparative Pathology |
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Format: | Article in Journal/Newspaper |
Language: | English |
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1997
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Online Access: | https://orbit.dtu.dk/en/publications/60ad0382-c3c1-4323-b234-8876acc43b9b https://doi.org/10.1016/S0021-9975(97)80083-7 |
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ftdtupubl:oai:pure.atira.dk:publications/60ad0382-c3c1-4323-b234-8876acc43b9b 2024-03-31T07:53:49+00:00 Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions Gustafsson, K. Wattrang, E. Fossum, C. Heegaard, Peter M. H. Lind, Peter Uggla, A. 1997 https://orbit.dtu.dk/en/publications/60ad0382-c3c1-4323-b234-8876acc43b9b https://doi.org/10.1016/S0021-9975(97)80083-7 eng eng https://orbit.dtu.dk/en/publications/60ad0382-c3c1-4323-b234-8876acc43b9b info:eu-repo/semantics/restrictedAccess Gustafsson , K , Wattrang , E , Fossum , C , Heegaard , P M H , Lind , P & Uggla , A 1997 , ' Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions ' , Journal of Comparative Pathology , vol. 117 , no. 4 , pp. 361-369 . https://doi.org/10.1016/S0021-9975(97)80083-7 article 1997 ftdtupubl https://doi.org/10.1016/S0021-9975(97)80083-7 2024-03-06T00:48:15Z As already reported, the mountain hare is much more susceptible than the domestic rabbit to oral inoculation with Toxoplasma gondii, as judged by pathological changes and dissemination of parasites within the body. In the present paper, further interspecies variations are reported. Concentrations of the acute phase reactant haptoglobin were raised in hares but not in rabbits one week post-infection (pi), probably reflecting the severe tissue damage present. No difference in the early humoral immune response of hares and rabbits was found, both species producing IgM and IgG antibodies to T. gondii one week pi. Lymphocyte stimulation tests performed before and one week after inoculation showed a high proliferative response to the parasite in blood cell cultures from rabbits but not hares. The fatal outcome of T. gondii infection in the hares is probably due, at least in part, to the lack of cellular response. Article in Journal/Newspaper Lepus timidus mountain hare Technical University of Denmark: DTU Orbit Journal of Comparative Pathology 117 4 361 369 |
institution |
Open Polar |
collection |
Technical University of Denmark: DTU Orbit |
op_collection_id |
ftdtupubl |
language |
English |
description |
As already reported, the mountain hare is much more susceptible than the domestic rabbit to oral inoculation with Toxoplasma gondii, as judged by pathological changes and dissemination of parasites within the body. In the present paper, further interspecies variations are reported. Concentrations of the acute phase reactant haptoglobin were raised in hares but not in rabbits one week post-infection (pi), probably reflecting the severe tissue damage present. No difference in the early humoral immune response of hares and rabbits was found, both species producing IgM and IgG antibodies to T. gondii one week pi. Lymphocyte stimulation tests performed before and one week after inoculation showed a high proliferative response to the parasite in blood cell cultures from rabbits but not hares. The fatal outcome of T. gondii infection in the hares is probably due, at least in part, to the lack of cellular response. |
format |
Article in Journal/Newspaper |
author |
Gustafsson, K. Wattrang, E. Fossum, C. Heegaard, Peter M. H. Lind, Peter Uggla, A. |
spellingShingle |
Gustafsson, K. Wattrang, E. Fossum, C. Heegaard, Peter M. H. Lind, Peter Uggla, A. Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions |
author_facet |
Gustafsson, K. Wattrang, E. Fossum, C. Heegaard, Peter M. H. Lind, Peter Uggla, A. |
author_sort |
Gustafsson, K. |
title |
Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions |
title_short |
Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions |
title_full |
Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions |
title_fullStr |
Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions |
title_full_unstemmed |
Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions |
title_sort |
toxoplasma gondii infection in the mountain hare (lepus timidus) and domestic rabbit (oryctolagus cuniculus). ii. early immune reactions |
publishDate |
1997 |
url |
https://orbit.dtu.dk/en/publications/60ad0382-c3c1-4323-b234-8876acc43b9b https://doi.org/10.1016/S0021-9975(97)80083-7 |
genre |
Lepus timidus mountain hare |
genre_facet |
Lepus timidus mountain hare |
op_source |
Gustafsson , K , Wattrang , E , Fossum , C , Heegaard , P M H , Lind , P & Uggla , A 1997 , ' Toxoplasma gondii infection in the mountain hare (Lepus timidus) and domestic rabbit (Oryctolagus cuniculus). II. Early immune reactions ' , Journal of Comparative Pathology , vol. 117 , no. 4 , pp. 361-369 . https://doi.org/10.1016/S0021-9975(97)80083-7 |
op_relation |
https://orbit.dtu.dk/en/publications/60ad0382-c3c1-4323-b234-8876acc43b9b |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/S0021-9975(97)80083-7 |
container_title |
Journal of Comparative Pathology |
container_volume |
117 |
container_issue |
4 |
container_start_page |
361 |
op_container_end_page |
369 |
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1795033946405208064 |