Oxidant-induced modifications in the mucosal transcriptome and circulating metabolome of Atlantic salmon

• Published in: Aquatic Toxicology
• Main Authors: Lazado, Carlo C., Pedersen, Lars-Flemming, Kirste, Katrine H., Soleng, Malene, Breiland, Mette W., Timmerhaus, Gerrit
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2020
• Subjects: Amoebic gill disease; Aquaculture; Disinfectant; Mucosal immunity; Oxidative tree; Peroxide; Metabolomics; Paa; Atlantic salmon; Salmo salar
• Online Access: https://orbit.dtu.dk/en/publications/4acf3e6d-76f0-4a4c-b94a-1a91df359f25; https://doi.org/10.1016/j.aquatox.2020.105625; https://backend.orbit.dtu.dk/ws/files/220715750/1_s2.0_S0166445X20303751_main.pdf

Here we report the molecular networks associated with the mucosal and systemic responses to peracetic acid (PAA), a candidate oxidative chemotherapeutic in Atlantic salmon (Salmo salar). Smolts were exposed to different therapeutic doses (0, 0.6 and 2.4 mg/L) of PAA for 5 min, followed by a re-expos...